Correlation between apparent diffusion coefficient and pathological pattern and prognostic factors of rectal cancer

SHEN Lu; TANG Fei; LIN Yi; ZHOU Jie; WANG Yibing; ZONG Genlin; XI Qian; ZHANG Lei

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Correlation between apparent diffusion coefficient and pathological pattern and prognostic factors of rectal cancer

更新时间：2025-12-15

- Correlation between apparent diffusion coefficient and pathological pattern and prognostic factors of rectal cancer
- Vol. 26, Issue 1, Pages: 43-48(2017)
- 作者机构：
- 作者简介：
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  CLC：
- Published Online：13 April 2017，
  
  Published：13 April 2017
- 稿件说明：
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沈璐,唐菲,林翌,等. 3.0T表观扩散系数与直肠癌病理分型及预后指标的相关性[J]. 肿瘤影像学, 2017, 26(1): 43-48
DOI：

沈璐,唐菲,林翌,等. 3.0T表观扩散系数与直肠癌病理分型及预后指标的相关性[J]. 肿瘤影像学, 2017, 26(1): 43-48 DOI：

摘要

目的：

探讨表观扩散系数(apparent diffusion coefficient，ADC)与直肠癌患者病理类型及预后指标的相关性。

方法：

对72例直肠癌患者进行回顾性分析，比较不同组别患者ADC值，并用受试者工作特征(receiver operating characteristic，ROC)曲线确定各因素的ADC鉴别界值。

结果：

不同T分期的患者ADC值有显著差异，淋巴结外肿瘤种植阳性患者ADC值明显低于阴性患者，术前糖类抗原19-9(carbohydrate antigen19-9，CA19-9)35 g/mL的患者ADC值明显低于CA19-9＜35 g/mL的患者。ADC值对T2/T3~4、淋巴外肿瘤种植及术前CA19-9水平的鉴别界值分别为1.21510

-3

、1.33510

-3

和1.16510

-3

/s。

结论：

ADC值与直肠癌预后指标相关性较强，具有一定的预测价值，有望成为一种无创的直肠癌预后生物学标志物。

Abstract

Objective:

To analyze the correlation between pre-treatment apparent diffusion coefficient (ADC) and pathological pattern and prognostic factors of rectal cancer.

Methods:

The data of 72 rectal cancer patients were retrospectively analyzed

and the ADC values were compared. The ADC cut-off value for each prognosis factor was determined with receiver operating characteristic (ROC) curve.

Results:

The ADC values of different T stages were statistically significant. The ADC values of tumors with extranodal tumor deposits or carbohydrate antigen19-9 (CA19-9) level 35 g/m

L were significantly lower. The ADC cut-off values for T2/T3-4

extranodal tumor deposits and preoperative CA19-9 level were 1.21510

-3

1.33510

-3

and 1.16510

-3

respectively.

Conclusion:

The ADC value of rectal cancer is strongly associated with the prognostic factors of rectal cancer

which indicates that the ADC value is a potential new noninvasive biomarker for rectal cancer prognosis.

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