Values of <sup>18</sup>F-fluorodeoxyglucose PET/CT and serum carbohydrate antigen 125 in diagnosis of recurrent and metastatic ovarian cancers

YU Lijuan; SUN Yanqin; XU Jiyou

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Values of ¹⁸F-fluorodeoxyglucose PET/CT and serum carbohydrate antigen 125 in diagnosis of recurrent and metastatic ovarian cancers

更新时间：2025-12-15

- Values of ¹⁸F-fluorodeoxyglucose PET/CT and serum carbohydrate antigen 125 in diagnosis of recurrent and metastatic ovarian cancers
- Vol. 25, Issue 1, Pages: 50-55(2016)
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- Published Online：04 May 2016，
  
  Published：04 May 2016
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于丽娟,孙艳芹,徐继有. ¹⁸F-脱氧葡萄糖PET/CT及血清糖类抗原125检测在卵巢癌术后复发和转移诊断中的价值[J]. 肿瘤影像学, 2016, 25(1): 50-55
DOI：

于丽娟,孙艳芹,徐继有. ¹⁸F-脱氧葡萄糖PET/CT及血清糖类抗原125检测在卵巢癌术后复发和转移诊断中的价值[J]. 肿瘤影像学, 2016, 25(1): 50-55 DOI：

摘要

目的：

探讨18F-脱氧葡萄糖(

F-fluorodeoxyglucose，

F-FDG)PET/CT及血清糖类抗原125(carbohydrate antigen 125，CA125)诊断卵巢癌术后复发及转移的价值。

方法：

收集101例术后行

F-FDG PET/CT检查的卵巢癌患者资料，所有患者均施行肿瘤细胞减灭术及血清CA125检测(与PET/CT检查间隔时间7 d)。复发及转移的判断以二次手术病理或穿刺病理为金标准；没有病理结果者以临床随访结果为标准(最短随访时间＞6个月)。应用SPSS 18.0软件进行分析，

＜0.05为差异有统计学意义。

结果：

F-FDG PET/CT和血清CA125对卵巢癌术后病变定性诊断的灵敏度、特异度、阳性预测值、阴性预测值、准确率分别为94.1%、97.1%，81.8%、12.1%，91.4%、69.5%，87.1%、66.7%，90.1%、69.3%。以最大标准化摄取值(maximum standardized uptake value，SUV

max

)2.5、SUV

max

1.3为阈值，对卵巢癌术后复发及转移诊断的灵敏度、特异度、阳性预测值、阴性预测值和准确率分别为94.1%、95.6%，81.8%、84.8%，91.4%、92.9%，87.1%、90.3%，90.1%、92.1%。以CA12535 U/mL、CA12565 U/mL为阈值，对卵巢癌术后复发及转移诊断的灵敏度、特异度、阳性预测值、阴性预测值和诊断准确率分别为97.1%、88.2%，12.1%、72.7%，69.5%、87.0%，66.7%、75.0%，69.3%、83.2%。SUV

max

与血清CA125值之间具有线性关系（

=0.595）。

结论：

对于卵巢癌术后复发和转移的诊断，

F-FDG PET/CT的特异度和准确率高于CA125(35 U/mL)。

Abstract

Objective:

To evaluate the values of

F-fluorodeoxyglucose (

F-FDG) PET/CT a

nd serum carbohydrate antigen 125 (CA125) in the diagnosis of recurrent and metastatic ovarian cancers.

Methods:

A total of 101 consecutive patients with ovarian cancer who underwent

F-FDG PET/CT after cytoreductive surgery were chosen. The serum CA125 level was detected within one week before or after PET/CT examination. The gold standard of recurrence or metastasis was based on pathological results acquired from reoperation or biopsy. For the patients without pathological results

the long-term follow-up (at least 6 months) results were set as standard. All the data analyses were carried out by software package SPSS 18.0

and

0.05 was established as the threshold for significance.

Results:

The sensitivity

specificity

positive predicted value (PPV)

negative predicted value (NPV) and accuracyof PET/CT and serum CA125 for recurrence and metastasis was 94.1%

81.8%

91.4%

87.1%

90.1%

and 97.1%

12.1%

69.5%

66.7 %

69.3%

respectively. When the maximum standardized uptake value (SUV

max

) thresholds were set as 2.5 and 1.3

the corresponding diagnostic values were 94.1%

81.8%

91.4%

87.1%

90.1%

and 95.6%

84.8%

92.9%

90.3%

92.1%

respectively. When the thresholds were CA125 35 U/ml and CA125 65 U/ml

the corresponding values were 97.1%

12.1%

69.5%

66.7%

69.3%

and 88.2%

72.7%

87.0%

75.0%

83.2%

respectively. There was a linear relationship between SUV

max

and serum CA125 value (

= 0.595).

Conclusion:

Compared to serum CA125

F-FDG PET/CT is a useful technique to detect recurrent and metastatic ovarian cancer in terms of specificity and accuracy.

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Values of 18F-fluorodeoxyglucose PET/CT and serum carbohydrate antigen 125 in diagnosis of recurrent and metastatic ovarian cancers

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Values of ¹⁸F-fluorodeoxyglucose PET/CT and serum carbohydrate antigen 125 in diagnosis of recurrent and metastatic ovarian cancers