Comparison of diffusion-weighted imaging and pathological prognostic factors in rectal cancer

SUN Yiqun; TONG Tong; XIN Chao; BI Rui; GU Yajia

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Comparison of diffusion-weighted imaging and pathological prognostic factors in rectal cancer

更新时间：2025-12-15

- Comparison of diffusion-weighted imaging and pathological prognostic factors in rectal cancer
- Vol. 24, Issue 2, Pages: 123-128(2015)
- 作者机构：
  
  1. 复旦大学附属肿瘤医院放射诊断科，复旦大学上海医学院肿瘤学系,上海,200032
  2. 复旦大学附属肿瘤医院病理科，复旦大学上海医学院肿瘤学系,上海,200032
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published Online：10 August 2015，
  
  Published：10 August 2015
- 稿件说明：
移动端阅览
孙轶群,童彤,信超,等. 直肠癌弥散加权成像与病理预后因子的对照研究[J]. 肿瘤影像学, 2015, 24(2): 123-128
DOI：

孙轶群,童彤,信超,等. 直肠癌弥散加权成像与病理预后因子的对照研究[J]. 肿瘤影像学, 2015, 24(2): 123-128 DOI：

摘要

目的：

探讨表观弥散系数(ADC)与直肠癌患者病理预后因子的相关性。

方法：

回顾性收集49例未行新辅助治疗而直接手术治疗的直肠癌患者临床资料，内容包括分化程度、T分期、N分期、神经及脉管是否受侵及是否存在癌结节；免疫组化包括Ki-67、p53及p21的表达情况。测量49例直肠癌患者术前病灶ADC值(b=800 s/mm

)。对不同组别[包括不同分化程度、T1~2对T3~4，N0对N+、环周切缘(-)对(+)、神经侵犯(-)对(+)、脉管癌栓(-)对(+)及癌结节(-)对(+)

]

之间的ADC值进行比较；同时对不同p53及p21表达组之间的ADC值进行比较，计算Ki-67标记指数(LI)与ADC值的相关系数。

结果：

统计学分析显示，两名医师对ADC值测量具有很好的一致性(

=0.775)。本研究中，T1~2组ADC值显著高于T3~4组(

=0.001)；N0组ADC值显著高于N+组(

=0.017)。ADC值与Ki-67 LI呈负相关(

=-0.318）且具有统计学意义(

=0.026)。ADC值在其他组别之间差异无统计学意义。

结论：

直肠癌ADC值与其病理预后因子相关，在一定程度上反映了其生物学特性，有望作为直肠癌非创伤性影像生物标记。

Abstract

Objective:

To analyze the correlation between pre-treatment apparent diffusion coefficient (ADC) and histological and immunohistochemical properties of rectal cancer.

Methods:

Forty-nine rectal cancer patients who received surgical resection without neoadjuvant therapy were selected. They underwent primary MRI and diffusion-weighted imaging (DWI). Tumor ADC values were determined and compared with the histological and immunohistochemical results

Results:

Inter-observer a

greement with confidence levels from two separate observers was suitable for ADC measurement (

=0.775). The pre-treatment ADC values of T1-2 stage tumors were significantly higher than T3-4 stage ones (

=0.001) and the ADC values of N0 stage tumors were significantly higher than to N+ ones (

=0.017). The overall trend was that higher T and N stages were correlated with lower ADC values. There was a negative correlation between Ki-67 labelling index (LI) and ADC values (

=-0.318

=0.026).

Conclusion:

There are significant correlations between pre-treatment ADC values and T stage

N stage and Ki-67 LI. Lower ADC values are associated with more aggressive tumor behaviors. Therefore

ADC value may represent a useful biomarker for assessing the biological features of identified rectal cancer.

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