Relationship between <sup>18</sup>F-fluorodeoxyglucose PET/CT and diffusion weighted imaging in primary central nervous system lymphoma

ZHOU Weiyan; WEN Jianbo; HUA Fengchun; KONG Yanyan; ZHANG Zhengwei; LU Xiuhong; GUAN Yihui

您当前的位置：

首页 >

文章列表页 >

Relationship between ¹⁸F-fluorodeoxyglucose PET/CT and diffusion weighted imaging in primary central nervous system lymphoma

更新时间：2025-12-15

- Relationship between ¹⁸F-fluorodeoxyglucose PET/CT and diffusion weighted imaging in primary central nervous system lymphoma
- Vol. 25, Issue 3, Pages: 257-262(2016)
- 作者机构：
  
  1. 复旦大学附属华山医院PET中心,上海,200235
  2. 复旦大学附属华山医院放射科,上海,200040
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published Online：02 November 2016，
  
  Published：02 November 2016
- 稿件说明：
移动端阅览
周维燕,文剑波,华逢春,等. ¹⁸F-脱氧葡萄糖PET/CT与弥散加权成像在原发性中枢神经系统淋巴瘤中的相关性研究[J]. 肿瘤影像学, 2016, 25(3): 257-262
DOI：

周维燕,文剑波,华逢春,等. ¹⁸F-脱氧葡萄糖PET/CT与弥散加权成像在原发性中枢神经系统淋巴瘤中的相关性研究[J]. 肿瘤影像学, 2016, 25(3): 257-262 DOI：

摘要

目的：

本研究回顾性分析原发性中枢系统淋巴瘤(primary central nervous system lymphoma，PCNSL)病灶

F-脱氧葡萄糖(

F-fluorodeoxyglucose，

F-FDG)半定量摄取与表观扩散系数(apparent diffusion coefficient，ADC)之间的关系。

方法：

纳入14例在复旦大学附属华山医院同时行FDG PET/CT及弥散加权成像(diffusion weighted imaging，DWI)检查的初诊PCNSL患者。手动在经滤波反投影(filtered back projection，FBP)重建后的脑PET图勾画PCNSL病灶感兴趣区(region of interest，ROI)，测算肿瘤FDG摄取半定量参数平均标准摄取值(mean standardized uptake value，SUVmean)及最大标准摄取值(maximum standardzed uptake value，SUVmax)。在ADC图上肿瘤实质、对侧相应正常脑白质区各自勾画ROI并分别测定ADC值，病灶ADC值取最小值(ADCmin)，对侧正常脑白质ADC值取平均值(ADCmean)，rADC为病灶ADCmin与对侧正常脑白质ADCmean的比值。采用Pearson分析对SUV与ADC半定量参数之间的相关性进行分析。

结果：

14例PCNSL患者共计纳入18个病灶，SUVmax与rADC(

=-0.584，

=0.011)、SUVmean与rADC(

=-0.559，

=0.016)均呈负相关。

结论：

基于病灶分析的治疗前SUV与ADC值存在负相关，PCNSL肿瘤细胞的代谢信息与其致密程度存在相关性，为DWI作为FDGPET诊断PCNSL和进行疗效监测的替代技术提供了一定的理论依据。

Abstract

Objective:

To retrospectively evaluate the relationship between

F-fluorodeoxyglucose (

F-FDG) uptake using PET/CT and apparent diffusion coefficient

(ADC) in patients with primary central nervous system lymphoma (PCNSL).

Methods:

A total of 14 PCNSL cases with 18 lesions underwent both FDG PET/CT scan and diffusion weighted imaging at onset. The meanstandardized uptake value (SUVmean) and maximum standardized uptake value (SUVmax) were calculated to assess the tumor FDG uptake on brain PET/CT images with filtered back projection (FBP) reconstruction. On ADC map

ADCmin of the lesions and ADCmean of the contralateral normal white matters were calculated. The relative ADC (rADC) was obtained by the ratio of ADCmin of the tumor to ADCmean of the contralateral normal white matter. Pearsons correlation analysis was used to assess the relationship between FDG uptake and ADC-derived parameters.

Results:

Negative correlations between SUVmax and rADC

between SUVmean and rADC were found for PCNSL cases (

=-0.584

=0.011;

=-0.559

=0.016

respectively).

Conclusion:

There is negative correlation between SUV and rADC before treatment. Both FDG PET/CT and DWI are useful methods in diagnosing PCNSL by evaluating tumor metabolic activity and cellular density. They are closely correlated. DWI could be an alternative imaging technique for FDG PET/CT in the diagnosis and therapy monitoring of PCNSL.

关键词

Keywords

references

Views

1645

下载量

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Diagnostic efficiency and inter-observer agreement among readers with variable experience of PI-RR system: using whole-mount histology after androgen deprivation therapy as reference

The influence of the changes of region of interest on histogram features in different grades of prostate carcinoma

Research progress on tumor heterogeneity by ¹⁸F-FDG PET/CT images using texture analysis

Evaluation of lymph node metastasis of cervical cancer by ¹⁸F-fluorodeoxyglucose PET/CT imaging

Value of 18F-fluorodeoxyglucose PET/CT imaging combined with serum carbohydrate antigen 125 and human epididymis protein 4 detection in diagnosis of ovarian malignancy

Related Author

LIU Xiaohang nbsp

YANG Lirui

GAN Hualei

LIU Wei

ZHOU Bingni

CHEN Zhangzhe

PENG Weijun

ZHOU Liangping

Related Institution

Department of Pathology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University

Department of Radiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University

Department of Radiology, Shanghai Geriatric Medical Center

Department of Pathology, Fudan University, Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University

Department of Diagnostic Songraphy, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University

AI问答

⁰

Relationship between 18F-fluorodeoxyglucose PET/CT and diffusion weighted imaging in primary central nervous system lymphoma

DOI：

摘要

Abstract

关键词

Keywords

references

Relationship between ¹⁸F-fluorodeoxyglucose PET/CT and diffusion weighted imaging in primary central nervous system lymphoma