Objective:

To explore the advantages and disadvantages of three methods of thyroid nodule biopsy under ultrasound guidance and the clinical application value.

Methods:

A total of 178 cases of thyroid nodules from Fudan University Shanghai Cancer Center were examined by ultrasound. In group A

55 cases were examined by ultrasound-guided 18G needle biopsy for histological examination. In group B

61 cases underwent ultrasound-guided fine needle biopsy using 21G needle. In group C

62 cases underwent ultrasound-guided aspi

ration biopsy cytology. The results of preoperative and postoperative pathological diagnosis of 72 cases with surgery were compared.

Results:

In group A

19 cases had papillary thyroid carcinoma

1 case had follicular carcinoma

7 cases had nodular goiter and 1 case had Hashimotos thyroiditis. Compared with the surgical pathology

the diagnostic accordance rate was 96.43% (27/28). In group B

15 cases had papillary thyroid carcinoma

4 cases had nodular goiter

1 case had thyroid adenoma and 1 case had subacute thyroiditis. Compared with the surgical pathology

the diagnostic accordance rate was 95.24% (20/21). In group C

6 cases had nodular goiter

3 cases had thyroid adenoma

1 case had Hashimotos thyroiditis and 1 case had subacute thyroiditis. Compared with the surgical pathology

the diagnostic accordance rate was 82.61% (19/23). In group A

bleeding hematoma was found in 14 cases

and false aneurysm formation in one case. In group B

bleeding hematoma was found in one case. There were no complications in group C.

Conclusion:

The diagnostic rates of needle biopsy and fine needle biopsy are similar but the complication incidence of thick needle biopsy is significantly higher than that of fine needle biopsy. The diagnostic accuracy of biopsy cytology is lower than that of puncture biopsy

but it has the advantages of no complications and being guided from multi angle and multi direction.