Relationship between metabolic parameters of <sup>18</sup>F-fluorodeoxyglucose PET/CT of bone metastases and serum markers in the patients with prostate cancer

REN Jiazhong; ZHAO Fen; HUO Zongwei; WANG Xiaohui; LIU Yan; YANG Guoren

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Relationship between metabolic parameters of ¹⁸F-fluorodeoxyglucose PET/CT of bone metastases and serum markers in the patients with prostate cancer

更新时间：2025-12-15

- Relationship between metabolic parameters of ¹⁸F-fluorodeoxyglucose PET/CT of bone metastases and serum markers in the patients with prostate cancer
- Vol. 27, Issue 1, Pages: 1-6(2018)
- 作者机构：
  
  1. 山东省济宁市第一人民医院放射科,山东,济宁,272000
  2. 山东省医学科学院,山东,济南,250062
  3. 山东大学附属山东省肿瘤医院放疗科,山东,济南,250117
  4. 山东大学附属山东省肿瘤医院核医学科,山东,济南,250117
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published Online：03 April 2018，
  
  Published：03 April 2018
- 稿件说明：
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任佳忠,赵芬,霍宗伟,等. 前列腺癌骨转移¹⁸F-脱氧葡萄糖PET/CT代谢参数与肿瘤标志物的相关性研究[J]. 肿瘤影像学, 2018, 27(1): 1-6
DOI：

任佳忠,赵芬,霍宗伟,等. 前列腺癌骨转移¹⁸F-脱氧葡萄糖PET/CT代谢参数与肿瘤标志物的相关性研究[J]. 肿瘤影像学, 2018, 27(1): 1-6 DOI：

摘要

目的：

研究前列腺癌骨转移

F-脱氧葡萄糖（

F-fluorodeoxyglucose，

F-FDG）PET/CT代谢参数与血清肿瘤标志物的相关性。

方法：

回顾性分析2012年1月2014年12月于山东大学附属山东省肿瘤医院入院1周内行

F-FDG PET/CT检查的48例前列腺癌患者的资料，通过

F-FDG PET/CT图像获得病灶数量、最大标准摄取值（maximum standardized uptake value，SUV

max

）、平均SUV（mean SUV，SUV

mean

）、肿瘤代谢体积（metabolic tumor volume，MTV）和总病灶糖酵解值（total lesion glycolysis，TLG），并与患者同期血清肿瘤标志物总前列腺特异性抗原（total prostate-specific antigen，tPSA）、游离前列腺特异性抗原（free prostate-specific antigen，fPSA）和碱性磷酸酶（alkaline phosphatase，ALP）进行相关性分析。

结果：

对于发生骨转移的前列腺癌患者，骨转移灶数量为8个是预测前列腺癌患者总生存期（overall survival，OS）的最佳界值点，并以此将患者分为无骨转移组、局限性骨转移组（1~8个）和弥漫性骨转移组（＞8个）。除局限性骨转移组与无骨转移组间ALP水平差异无统计学意义外，各组间tPSA、fPSA和ALP水平差异均有统计学意义。骨转移灶的数量与患者同期tPSA、fPSA和ALP水平均呈正相关（

=0.604，

=0.02；

=0.531，

=0.03；

=0.478，

=0.018）。除前列腺癌骨转移灶SUV

max

与同期ALP水平，以及SUV

mean

与同期fPSA、ALP水平相关关系不显著外，其余均有相关性。

结论：

前列腺癌患者骨转移灶数量为8个是预测前列腺癌患者OS的最佳界值点；tPSA、fPSA和ALP均可作为评价前列腺癌弥漫性骨转移的临床血生化指标；

MTV

和

TLG

联合同期tPSA、fPSA和ALP水平在评价前列腺癌患者骨转移程度方面优于SUV

max

和SUV

mean

；

TLG

可用于评价前列腺癌患者的预后。

Abstract

Objective:

To investigate the relationship between metabolic parameters of 18F-fluorodeoxyglucose (

F-FDG) PET/CT of bone metastases and serum markers in the patients with prostate cancer.

Methods:

Retrospective analysis was carried out in 48 patients with prostate cancer hospitalized in Shandong Cancer Hospital Affiliated to Shandong University from Jan. 2012 to Dec. 2014. The patients underwent

F-FDG PET/CT examination within a week after admission. The relationship between metabolic parameters of

F-FDG PET/CT such as number of metastatic bone lesion

maximum standardized uptake value (SUV

max

)

mean SUV (SUV

mean

)

metabolic tumor volume (MTV) and total lesion glycolysis (TLG) and serum tumor markers in the corresponding period were analyzed.

Results:

The number of metastatic bone lesion of 8 was set as the best cutoff point to predict the overall survival (OS) of the patients with prostate cancer

who were divided into no bone metastasis group

limited bone metastasis group (1-8 lesions) and diffuse bone metastasis group (more than 8 lesions). There was significant difference in the level of alkaline phosphatase (ALP) between limited bone metastasis group and no bone metastasis group. The levels of total prostate-specific antigen (tPSA)

free frostatespecific awtigen (fPSA) and ALP were statistically significant among three groups. The positively correlated relationship was shown between the number of metastatic bone lesion and the corresponding levels of tPSA

fPSA and ALP (

=0.604

=0.02;

=0.531

=0.03;

=0.478

=0.018). There was no correlation between SUV

max

value of metastatic bone lesion and the level of ALP

between SUV

mean

value of metastatic bone lesion and the levels of ALP and fPSA. The rest para

meters and biomarkers were correlated.

Conclusion:

The number of metastatic bone lesion of 8 is the optimal cutoff point to predict the OS of patients with prostate cancer. tPSA

fPSA and ALP can be used as clinical blood biochemical indicators for diffuse bone metastasis in the patients with prostate cancer.

MTV

and

TLG

combined with tPSA

fPSA and ALP are better than SUV

max

and SUV

mean

in evaluation of bone metastases.

TLG

could be used to evaluate the prognosis of prostate cancer.

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Related Institution

Department of Nuclear Medicine, Affilitated Hospital of Southwest Medical University

Department of Nuclear Medicine, Chengdu Seventh People’s Hospital, Affilitated Cancer Hospital of Chengdu Medical College

Department of Radiology, Chengdu Seventh People’s Hospital, Affilitated Cancer Hospital of Chengdu Medical College

Department of Radiology, Chongqing University Cancer Hospital

Major of Biology and Medicine, Bioengineering College of Chongqing University

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Relationship between metabolic parameters of 18F-fluorodeoxyglucose PET/CT of bone metastases and serum markers in the patients with prostate cancer

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摘要

Abstract

关键词

Keywords

references

Relationship between metabolic parameters of ¹⁸F-fluorodeoxyglucose PET/CT of bone metastases and serum markers in the patients with prostate cancer