The value of <sup>18</sup>F-FDG PET/CT in differential diagnosis of malignant pleural mesothelioma and metastatic pleural adenocarcinoma

ZHANG Xiaoying; HUANG Ping; SUN Zhen; MAO Minhang; CHEN Tao

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The value of ¹⁸F-FDG PET/CT in differential diagnosis of malignant pleural mesothelioma and metastatic pleural adenocarcinoma

更新时间：2025-12-15

- The value of ¹⁸F-FDG PET/CT in differential diagnosis of malignant pleural mesothelioma and metastatic pleural adenocarcinoma
- Vol. 26, Issue 6, Pages: 409-414(2017)
- 作者机构：
  
  1. 上海中医药大学附属曙光医院核医学科,上海,201203
  2. 上海交通大学附属胸科医院胸外科,上海,200052
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published Online：19 January 2018，
  
  Published：19 January 2018
- 稿件说明：
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张晓莹,黄平,孙震,等. ¹⁸F-FDG PET/CT在恶性胸膜间皮瘤与胸膜转移性腺癌鉴别诊断中的价值[J]. 肿瘤影像学, 2017, 26(6): 409-414
DOI：

张晓莹,黄平,孙震,等. ¹⁸F-FDG PET/CT在恶性胸膜间皮瘤与胸膜转移性腺癌鉴别诊断中的价值[J]. 肿瘤影像学, 2017, 26(6): 409-414 DOI：

摘要

目的：

探讨

F-FDG PET/CT在恶性胸膜间皮瘤(malignant pleural mesothelioma，MPM)与胸膜转移性腺癌鉴别诊断中的关键表现及其在临床分期中的价值。

方法：

回顾性对比分析7年来因原因不明胸痛、胸膜增厚、胸腔积液行

FFDGPET/CT检查，后经病理证实的MPM和胸膜转移性腺癌患者各20例，比较两组患者胸腔积液程度、胸膜FDG积聚形态、SUV

max

及全身伴随征象，并判定MPM的TNM分期。

结果：

MPM组多为无或少量胸腔积液。胸膜FDG积聚形态类型比较发现，MPM组纵隔胸膜FDG积聚者明显多于胸膜转移性腺癌组(70%

20%，

0.01)，而两组间结节型、肿块型、不规则环形，以及叶间胸膜、横膈胸膜FDG积聚的发生率差异无统计学意义，两组间胸膜SUV

max

差异也无统计学意义。全身伴随征象中，发生肺门和纵隔淋巴结转移者MPM组明显少于胸膜转移性腺癌组(25%

80%，

0.05)，而心包、胸壁和肋骨侵犯，同侧胸廓体积缩小在MPM组中明显增多(50%

20%，

0.05；75%

25%，

0.01)。MPM组临床TNM分期中，Ⅰ~Ⅱ期为60%，Ⅲ~Ⅳ期为40%。

结论：

F-FDG PET/CT发现纵隔胸膜FDG积聚是MPM与胸膜转移性腺癌鉴别诊断的关键表现，同时在MPM临床TNM分期中也发挥着重要作用。

Abstract

Objective:

To analyze the value of

F-FDG PET/CT in differential diagnosis of malignant pleural mesothelioma (MPM) and metastatic pleural adenocarcinoma and clinical staging of MPM.

Methods:

The

F-FDG PET/CT appearances of 20 cases with MPM and 20 cases with metastatic

pleural adenocarcinoma confirmed pathologically over 7 years were retrospectively reviewed

at the same time

the clinical TNM staging of MPM was investigated.

Results:

Pleural effusions were none or a little in MPM. Of pleural thickening uptake types

mediastinal pleural involvement was significantly different (

0.05). While nodular pleural thickening

mass pleural thickening

rind-like pleural irregular thickening

fissure pleural involvement

diaphragm involvement and maximum SUV

max

were not significantly different (

0.05). Mediastinal and (or) hilum lymph node enlargement

invasion of pericardium

chest wall and rib

decrease in the volume of affected thorax between the two groups were significantly different (

0.05). Clinically

Ⅰ-Ⅱ stage occupied 60%

Ⅲ-Ⅳ stage occupied 40% in MPM.

Conclusion:

Mediastinal pleural involvement is a critical appearance in differential diagnosis of MPM and metastatic pleural adenocarcinoma.

F-FDG PET/CT has important value in clinical TNM staging of MPM.

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Related Institution

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The value of 18F-FDG PET/CT in differential diagnosis of malignant pleural mesothelioma and metastatic pleural adenocarcinoma

DOI：

摘要

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The value of ¹⁸F-FDG PET/CT in differential diagnosis of malignant pleural mesothelioma and metastatic pleural adenocarcinoma