To investigate the value of ultrasound elasticity contrast index (ECI) in the differential diagnosis of thyroid nodules.
Methods:
A total of 85 patients with 120 thyroid nodules were examined with high resolution ultrasonography. Two-dimensional ultrasonographic features and distance to the carotid artery were recorded
and elastography was performed. The receiver operating characteristic (ROC) curve of ECI for differential diagnosis of benign and malignant thyroid nodules was
drawn with the surgical pathology as the gold standard.
Results:
Of the 120 nodules
65 were malignant and 55 were benign. The ECI value of malignant nodules was significantly higher than that of benign nodules (
P
0.01). The optimal cutoff value of ECI in differentiating benign and malignant thyroid nodules was 2.90. The ECI value in calcification group was significantly higher than that in non-calcification group (
P
0.01)
but no statistically significant difference was found between benign and malignant nodules within the two groups. The ECI values of all nodules and malignant nodules were closely related to the distance to the carotid artery
with the correlation coefficient of 0.298 and 0.397
respectively (
P
0.001). The diagnostic performance of ECI was superior in malignant nodules with distance to the carotid artery 10 mm than those with distance to the carotid artery 10 mm.
Conclusion:
ECI has certain values in the differential diagnosis of benign and malignant thyroid nodules and provides an important supplement to conventional ultrasound.
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Related Author
OU Shengsheng
LI Jie
WU Xinping
LUAN Yun
WU Yiyun
XU Huaning
SONG Xuguang
CAI Ting
Related Institution
Department of Ultrasound, Jinling Clinical Medical College, Nanjing Medical University, General Hospital of the Eastern Theater of the Chinese People's Liberation Army
Department of Ultrasound, The Fourth Affiliated Hospital of Nanjing Medical University
Department of Radiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University
Department of Radiology, Obstetrics & Gynecology Hospital, Fudan University
Department of Pathology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University