Correlation between diffusion weighted imaging and molecular biomarkers in breast invasive ductal carcinomas

LIU Li; YIN Bo; YUE Lei; MAO Jian; PENG Weijun

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Correlation between diffusion weighted imaging and molecular biomarkers in breast invasive ductal carcinomas

更新时间：2025-12-15

- Correlation between diffusion weighted imaging and molecular biomarkers in breast invasive ductal carcinomas
- Vol. 26, Issue 3, Pages: 199-204(2017)
- 作者机构：
  
  1. 复旦大学附属肿瘤医院放射诊断科，复旦大学上海医学院肿瘤学系,上海,200032
  2. 复旦大学附属华山医院放射科,上海,200040
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published Online：14 August 2017，
  
  Published：14 August 2017
- 稿件说明：
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刘莉,尹波,岳磊,等. 扩散加权成像与乳腺浸润性导管癌分子生物标记的相关性研究[J]. 肿瘤影像学, 2017, 26(3): 199-204
DOI：

刘莉,尹波,岳磊,等. 扩散加权成像与乳腺浸润性导管癌分子生物标记的相关性研究[J]. 肿瘤影像学, 2017, 26(3): 199-204 DOI：

摘要

目的：

研究表观扩散系数(apparent diffusion coefficient，ADC)与乳腺浸润性导管癌分子生物学标记之间的关系，以指导临床判断预后及选择治疗方案。

方法：

对67例乳腺浸润性导管癌患者进行磁共振扩散加权成像(diffusion weighted imaging，DWI)检查，并测量病灶ADC值。术后免疫组化分析人表皮生长因子受体2 (human epidermal growth factor receptor 2，HER-2)、雌激素受体(estrogen receptor，ER)、孕激素受体(progesterone receptor，PR)、Ki-67，统计学分析ADC值与ER、PR、HER-2、Ki-67的相关性，并研究不同分子分型病灶之间ADC值的差别。

结果：

Spearman相关性分析表明，ADC值与Ki-67之间无相关性(

＞0.05)；ER、PR、HER-2阴性表达者ADC值高于阳性者(

＜0.05)；三阴性病灶ADC值明显高于Luminal A型、Luminal B型、HER-2过表达型(

＜0.05)；HER-2过表达型病灶ADC值高于Luminal B型。

结论：

ADC值与乳腺浸润性导管癌分子生物标记及分子分型具有相关性，可辅助指导临床选择治疗方案及判断预后。

Abstract

Objective:

To investigate the relationship between apparent diffusion coefficient (ADC) value and molecular biomarkers in breast invasive ductal carcinomas (IDCs)

which may facilitate the optimal treatment and prognosis prediction.

Methods:

A total of 67 patients with IDC were enrolled in this study. All the patients underwent breast diffusion weighted magnetic resonance imaging (DW-MRI) before treatment. The ADC values of IDCs were calculated. The expressions of estrog

en receptor (ER)

progesterone receptor (PR)

Ki-67

human epidermal growth factor receptor 2 (HER-2) were analyzed by immunohistochemistry. The relationships between ADC values and ER

HER-2 and ki-67 expressions were statistically evaluated while the ADC values in different subtypes were also studied.

Results:

The ADC values of IDCs did not correlate significantly with Ki-67 by Spearmans correlation analysis (

0.05); The mean ADC value was higher in IDCs with negative ER

PR and HER-2 expressions than that with positive expressions (

0.05); The triple-negative IDC had higher mean ADC value than Luminal A

Luminal B and HER-2 overexpressing IDCs (

0.05); The mean ADC value in HER-2 overexpressing IDC was significantly higher than that in Luminal B type IDC (

0.05).

Conclusion:

The ADC value could be used to evaluate the expressions of molecular biomarkers and IDC subtype

which could help determine individual treatment and predict prognosis.

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