Advances in molecular imaging of prostate cancer targeting prostate specific membrane antigen with small molecular radionuclide probes

HU Silong; XU Xiaoping

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Advances in molecular imaging of prostate cancer targeting prostate specific membrane antigen with small molecular radionuclide probes

更新时间：2026-06-18

- Advances in molecular imaging of prostate cancer targeting prostate specific membrane antigen with small molecular radionuclide probes
- Vol. 24, Issue 3, Pages: 161-167(2015)
- 作者机构：
  
  1. 上海分子影像探针工程技术研究中心筹,上海,200032
  2. 复旦大学附属肿瘤医院核医学科，复旦大学上海医学院肿瘤学系,上海,200032
  3. 复旦大学生物医学影像研究中心,上海,200032
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：20 October 2015，
  
  Published：20 October 2015
- 稿件说明：
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胡四龙,章英剑. 以核素标记前列腺特异性膜抗原小分子抑制剂为探针的前列腺癌分子影像研究进展[J]. 肿瘤影像学, 2015, 24(3): 161-167
DOI：

胡四龙,章英剑. 以核素标记前列腺特异性膜抗原小分子抑制剂为探针的前列腺癌分子影像研究进展[J]. 肿瘤影像学, 2015, 24(3): 161-167 DOI：

摘要

前列腺特异性膜抗原(PSMA)高表达于前列腺癌及其转移灶中，可作为生物分子靶点，在前列腺癌的早期诊断、分期、复发检测、预后判断及靶向治疗中具有重要价值。本文重点综述以核素标记PSMA小分子抑制剂为探针的前列腺癌分子影像研究进展。

Abstract

Prostate specific membrane antigen (PSMA) is expressed in normal prostate epithelial cells and strongly up regulated in initial and advanced prostate carcinoma. Therefore

PSMA is an attractive molecular target for the detection of primary and metastatic lesions. It plays an important role in the diagnosis

staging

prognostic evaluation and targeted treatment in prostate carcinoma patients. This review will summarize the progress of small molecular radionuclide probes

which targeted PSMA

for visualizing prostate cancer.

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