Progress on molecular imaging agents targeting epidermal growth factor receptor in brain tumors

ZHANG Huiwei

您当前的位置：

首页 >

文章列表页 >

Progress on molecular imaging agents targeting epidermal growth factor receptor in brain tumors

更新时间：2026-06-18

- Progress on molecular imaging agents targeting epidermal growth factor receptor in brain tumors
- Vol. 25, Issue 3, Pages: 209-212(2016)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：02 November 2016，
  
  Published：02 November 2016
- 稿件说明：
移动端阅览
张慧玮管一晖审校. 以表皮生长因子受体为靶点的脑肿瘤分子显像剂研究进展[J]. 肿瘤影像学, 2016, 25(3): 209-212
DOI：

张慧玮管一晖审校. 以表皮生长因子受体为靶点的脑肿瘤分子显像剂研究进展[J]. 肿瘤影像学, 2016, 25(3): 209-212 DOI：

摘要

表皮生长因子受体(epidermal growth factor receptor，EGFR)属酪氨酸激酶型受体，EGFR基因扩增、重排和突变导致的EGFR蛋白过度表达是原发性胶质母细胞瘤中最常见的遗传变异。目前，常规肿瘤分子病理学手段不能对无法获得标本的胶质瘤患者进行检测，而PET通过影像学手段检测病灶。根据EGFR生物化学特征，靶向EGFR的显像剂可分为核素标记的酪氨酸激酶抑制剂和核素标记的单克隆抗体。

Abstract

Epidermal growth factor receptor (EGFR) is a kind of tyrosine kinase receptor. The EGFR gene amplification

reassortment and mutation lead to overexpress of EGFR protein

which is the common genetic variation of primary glioblastoma. The common oncological detection of molecular pathology is unable to test the patients without pathological specimens for some reasons. Positron emission tomography can test the lesions by imaging. According to the biochemical characters of EGFR

EGFR-targeted imaging agents are divided into radiolabeled tyrosine kinase inhibitor and radiolabeled monoclonal antibody.

关键词

Keywords

references

Views

1421

下载量

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Predictors of pathological grade in patients with brain stem glioma and its relationship with APT imaging

The non-invasive prediction analysis of radiomic features from 18 F-FET PET/CT dual imaging modality for tumor grading in untreated adult gliomas

Advances and prospects of PET/MRI of brain tumors

The value of 18 F-FDG PET/CT radiomic features for predicting EGFR gene mutation status in patients with lung adenocarcinoma

Research progress of amide proton transfer imaging in preoperative grading and postoperative recurrence assessment of glioma

Related Author

LIN Huiqing

HUANG Li

LIN Li

TANG Yilin

HUA Tao

ZHOU Weiyan

ZHOU Zhirui

HUANG Qi

Related Institution

Department of Radiotherapy, Huashan Hospital, Fudan University

Department of Nuclear Medicine/PET Center, Huashan Hospital, Fudan University

Medical Imaging School, North Sichuan Medical College, Nanchong

Department of Nuclear Medicine, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China

Department of Neurology, Shenzhen Longhua People&rsquo

AI问答

⁰