Proton MR spectroscopy in differentiating benign from borderline cystic epithelial ovarian tumors

MA Fenghua; ZHANG Guofu; QIANG Jinwei; TIAN Xiaomei; LI Haiming; RAO Yamin

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Proton MR spectroscopy in differentiating benign from borderline cystic epithelial ovarian tumors

更新时间：2026-06-18

- Proton MR spectroscopy in differentiating benign from borderline cystic epithelial ovarian tumors
- Vol. 25, Issue 1, Pages: 16-21(2016)
- 作者机构：
  
  1. 复旦大学附属妇产科医院放射科,上海,200011
  2. 复旦大学附属金山医院影像科,上海,201508
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：04 May 2016，
  
  Published：04 May 2016
- 稿件说明：
移动端阅览
马凤华,张国福,强金伟,等. ¹H-MRS鉴别良性与交界性囊性上皮性卵巢肿瘤的价值[J]. 肿瘤影像学, 2016, 25(1): 16-21
DOI：

马凤华,张国福,强金伟,等. ¹H-MRS鉴别良性与交界性囊性上皮性卵巢肿瘤的价值[J]. 肿瘤影像学, 2016, 25(1): 16-21 DOI：

摘要

目的：

探讨氢质子磁共振波谱(proton magnetic resonance spectroscopy，

H-MRS)鉴别良性与交界性囊性上皮性卵巢肿瘤(epithelial ovarian tumor，EOT)的价值。

方法：

回顾性分析64例经手术和病理证实的囊性EOT患者(良性33个、交界性31个)的1H-MRS资料，波谱序列采用点分辨自旋回波波谱，用波谱后处理软件自动获取各代谢物[胆碱(choline，Cho)、

-乙酰天冬氨酸(N-acetyl aspartate，NAA)、脂质(lipid，Lip)、乳酸(lactate，Lac)

]

的峰值积分，以肌酸(creatine，Cr)为内参照，计算各代谢物与Cr的比值。采用Mann-Whitney U检验比较良性与交界性EOT代谢物峰值积分比值的差异，采用受试者工作特征(receiver operating characteristic，ROC)曲线评价峰值积分比值鉴别良性与交界性EOT的效能，并确定鉴别两者的阈值。

结果：

良性和交界性囊性EOT的Cho/Cr比值分别为1.390.90(1.02~1.54)和3.311.60(2.12~3.92)，有显著性差异(

＜0.001)；NAA/Cr比值为2.542.20(1.43~3.45)和9.435.20(5.3~11.41)，有显著性差异(

＜0.001)。Cho/Cr和NAA/Cr鉴别良性与交界性囊性EOT的曲线下面积(area under curve，AUC)分别为0.901和0.907。

结论：

卵巢良性和交界性囊性EOT的1H-MRS模式不同，Cho/Cr和NAA/Cr比值在交界性囊性EOT中明显高于良性肿瘤，是较好的鉴别诊断生物标记。

Abstract

Objective:

To investigate the ability of proton magnetic resonance spectroscopy (

H-MRS) in differentiating benign from borderline cystic epithelial ovarian tumors (EOTs).

Methods:

Sixty-four patients with surgically and histologically proven cystic EOT (33 benign and 31 border

line) underwent 1H-MRS. Single voxel spectroscopy (SVS) or multi-voxel 2D-chemical shift imaging (CSI) was performed using point-resolved echo spin spectroscopy (PRESS). Resonance peak integrals of choline (Cho)

-acetyl aspartate (NAA)

creatine (Cr)

lactate (Lac)

and lipid (Lip) were analyzed and the Cho/Cr

NAA/Cr

Lac/Cr and Lip/Crratios were compared between the two groups using Mann-Whitney U test. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic performance of

H-MRS in differentiating benign from borderline EOTs.

Results:

The mean Cho/Cr ratios of benign and borderline EOTs were 1.390.90 and 3.311.60

respectively

with a statistically significant difference between the two groups (

0.001). The mean NAA/Cr ratios of benign and borderline EOTs were 2.542.20 and 9.435.20

respectively

with a statistically significant difference between the two groups (

0.001). Area under the curves of Cho/Cr and NAA/Cr ratios was 0.901 and 0.907 for differentiating benign from borderline EOTs.

Conclusion:

The

H-MRS patterns of benign and borderline cystic EOTs are different. The Cho/Cr and NAA/Cr ratios are higher in borderline EOT than benign cystic EOT and are perfect differential biomarkers.

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