The value of fine-needle aspiration cytology combined with BRAF<sup>V600E</sup> mutation detection in diagnosis of thyroid nodules

ZHANG Boming; LIN Yuanqiang; SUI Guoqing; WANG Yang; ZHAO Qianqian; WANG Hui

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The value of fine-needle aspiration cytology combined with BRAF^V600E mutation detection in diagnosis of thyroid nodules

更新时间：2026-06-18

- The value of fine-needle aspiration cytology combined with BRAF^V600E mutation detection in diagnosis of thyroid nodules
- Vol. 24, Issue 4, Pages: 259-263(2015)
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  CLC：
- Online First：19 January 2016，
  
  Published：2015
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张博茗,林元强,隋国庆,等. 细针穿刺细胞学联合BRAF^V600E基因突变检测在甲状腺结节诊断中的价值[J]. 肿瘤影像学, 2015, 24(4): 259-263
DOI：

张博茗,林元强,隋国庆,等. 细针穿刺细胞学联合BRAF^V600E基因突变检测在甲状腺结节诊断中的价值[J]. 肿瘤影像学, 2015, 24(4): 259-263 DOI：

摘要

目的：

研究细针穿刺细胞学(fine-needle aspiration cytology，FNAC)联合

BRAF

V600E

基因突变检测在甲状腺结节诊断中的应用价值。

方法：

收集2014年6月2015年6月因甲状腺结节至吉林大学中日联谊医院就诊且经超声检查可疑恶性的患者87例，均行超声引导下FNAC检查和穿刺标本

BRAF

V600E

突变荧光聚合酶链反应(polymerase chain reaction，PCR)检测。

结果：

术后病理诊断为恶性的64例患者中，术前FNAC阳性48例、阴性16例；

BRAF

V600E

突变40例。术后病理诊断为良性的23例患者中，术前FNAC阳性5例、阴性18例；

BRAF

V600E

突变0例。与术后病理结果对照，FNAC对甲状腺癌诊断的灵敏度为75.0%、特异度为78.3%、准确率为75.9%；

BRAF

V600E

突变检测的灵敏度为62.5%、特异度为100%、准确率为72.4%；FNAC联合

BRAF

V600E

突变检测的灵敏度为89.1%、特异度为78.3%、准确率为86.2%。

结论：

FNAC联合

BRAF

V600E

基因突变检测可提高甲状腺恶性结节诊断的灵敏度。

Abstract

Objective:

To investigate the application value of fine-needle aspiration cytology (FNAC) combined with BRAF mutation detection in the diagnosis of thyroid nodules.

Methods:

A total of 87 patients who were diagnosed as suspicious malignant thyroid nodules by ultrasonic examination from June 2014 to June 2015 were selected. All the patients underwent FNAC and BRAF mutat

ion detection by fluorescence polymerase chain reaction (PCR).

Results:

Among 64 malignant cases

48 cases were positive and 16 cases were negative for FNAC

and 40 cases had BRAF

V600E

mutation. Among 23 benign cases

5 cases were positive and 18 cases were negative for FNAC

and no case had BRAF

V600E

mutation. Compared with the postoperative pathological results

the sensitivity was 75.0%

the specificity was 78.3%

and the accuracy was 75.9% for FNAC. The sensitivity of BRAF mutation detection was 62.5%

the specificity was 100.0%

and the accuracy was 72.4%. The sensitivity was 89.1%

the specificity was 78.3%

and the accuracy was 86.2% for FNAC combined with BRAF

V600E

mutation detection.

Conclusion:

FNAC combined with BRAF

V600E

mutation detection can improve the sensitivity of diagnosis of malignant thyroid nodules.

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The value of fine-needle aspiration cytology combined with BRAFV600E mutation detection in diagnosis of thyroid nodules

DOI：

摘要

Abstract

关键词

Keywords

references

The value of fine-needle aspiration cytology combined with BRAF^V600E mutation detection in diagnosis of thyroid nodules