Comparison of stretched-exponential and monoexponential models of diffusion-weighted imaging between prostate cancer and normal tissues

ZHANG Ling; LIU Xiaohang; ZHOU Liangping; LIU Yin; MAO Jian

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Comparison of stretched-exponential and monoexponential models of diffusion-weighted imaging between prostate cancer and normal tissues

更新时间：2026-06-18

- Comparison of stretched-exponential and monoexponential models of diffusion-weighted imaging between prostate cancer and normal tissues
- Vol. 25, Issue 2, Pages: 131-136(2016)
- 作者机构：
  
  1. 复旦大学附属肿瘤医院放射诊断科，复旦大学上海医学院肿瘤学系,上海,200032
  2. 上海理工大学医疗器械与食品学院,上海,200093
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：18 August 2016，
  
  Published：18 August 2016
- 稿件说明：
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张灵,刘晓航,周良平,等. 外周带前列腺癌与正常组织的广延指数和单指数模型扩散加权成像的比较[J]. 肿瘤影像学, 2016, 25(2): 131-136
DOI：

张灵,刘晓航,周良平,等. 外周带前列腺癌与正常组织的广延指数和单指数模型扩散加权成像的比较[J]. 肿瘤影像学, 2016, 25(2): 131-136 DOI：

摘要

目的：

比较前列腺外周带癌与正常组织的广延指数和单指数模型弥散加权成像( d i f f u s i o n -weighted imaging

DWI)参数的差异。

方法：

25例外周带前列腺癌确诊患者行DWI检查，b值为0、500、1 000、2 0 0 0 s/mm

sup2;。通过单指数模型计算前列腺癌和正常组织的表观扩散系数(apparent d i f f u s i o n c o e f f i c i e n t ，ADC)，广延指数模型计算分布扩散系数(distributed d i f f u s i o n c o e f f i c i e n t ， D D C ) 和校正系数值。比较癌组织与正常组织之间ADC值、DDC值和值( 范围0~1)的差异，评价各组织中ADC值与DDC值的差异和相关性，并比较前列腺癌与正常组织之间A D C 值和D D C 值标准化差值。

结果：

共3 0 个前列腺癌病灶、3 4 个正常外周带组织纳入研究。前列腺癌组织A D C 值[ ( 0 . 7 3 0 . 1 4 ) 1 0

- 3

m m

/ s

]

、D D C 值[ ( 0 . 6 2 0 . 2 0 ) 1 0

- 3

m m

/ s

]

和值(0.650.10)均显著低于正常外周带[(1.430.25)10

-3

/s、(1.490.20)10

-3

/s、0.860.09；均

＜0.05)

]

。前列腺癌组织的ADC值明显高于DDC值，正常外周带组织的ADC值低于DDC值(均

＜0.05)。在前列腺癌及正常组织中，ADC值与DDC值均密切相关(

sup2;=0.98、0.98，均

＜0.05)，前列腺癌组织的ADC值和DDC值的标准化差值明显高于正常组织。

结论：

广延指数模型DWI为鉴别前列腺癌与正常组织提供了更多信息，有助于提高前列腺癌的诊断率。

Abstract

Objective:

To compare the parameters of stretched-exponential and monoexponential models of diffusionweighted

imaging (DWI) between prostate cancer and normal tissues.

Methods:

Twenty-five patients with peripheral zone prostate cancer underwent DWI exam using b-values of 0

500

1 000

and 2 000 s/mm

. The distributed diffusion coefficient (DDC) and values of prostate cancer and normal tissues were obtained using stretched-exponential model and apparent diffusion coefficient (ADC) values were obtained using monoexponential model. The ADC

DDC (both in 10

-3

/s) and values (range 0-1) were compared between prostate cancer and normal tissues. The ADC and DDC values were compared and correlated in each tissue

and the standardized differences between DDC and ADC values were compared between prostate cancer and normal tissues.

Results:

Data were obtained from 30 lesions and 34 normal peripheral zone tissue. The ADC (0.730.14)

DDC (0.620.20) and values (0.650.10) of tumor were all significantly lower than those of the normal tissues (1.430.25

1.490.20 and 0.860.09) (all

0.05). ADC value was significantly higher than DDC value in tumor but lower than DDC value in normal tissue (all

0.05). ADC value and DDC value were significantly correlated (

=0.98

0.98

respectively;

0.05) in prostate cancer and normal tissues

and the standardized difference between ADC value and DDC value in tumor was significantly higher than that in normal tissue.

Conclusion:

The stretched-exponential model of DWI provides more parameters for prostate cancer and normal tissues and would improve the diagnosis of prostate cancer.

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