The preliminary clinical application of MAMMI dedicated breast PET

BAO Xiao; HU Silong; CHEN Jingyi; YANG Zhongyi; LIU Shuai; LIU Rui; SUN Yifei; WANG Siyang; LIU Chang; YAO Zhifeng; ZHANG Yongping; ZHANG Yingjian

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The preliminary clinical application of MAMMI dedicated breast PET

更新时间：2026-06-18

- The preliminary clinical application of MAMMI dedicated breast PET
- Vol. 24, Issue 3, Pages: 179-184(2015)
- 作者机构：
  
  1. 复旦大学生物医学影像研究中心,上海,200032
  2. 上海分子影像探针工程技术研究中心筹,上海,200032
  3. 复旦大学附属肿瘤医院核医学科，复旦大学上海医学院肿瘤学系,上海,200032
  4. 上海市质子重离子医院核医学科,上海,201321
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：20 October 2015，
  
  Published：20 October 2015
- 稿件说明：
移动端阅览
鲍晓,胡四龙,程竞仪,等. 乳腺专用PET临床初步应用[J]. 肿瘤影像学, 2015, 24(3): 179-184
DOI：

鲍晓,胡四龙,程竞仪,等. 乳腺专用PET临床初步应用[J]. 肿瘤影像学, 2015, 24(3): 179-184 DOI：

摘要

目的：

探讨乳腺专用PET的临床应用价值。

方法：

选取76例于本院行

F-FDG PET/CT检查发现乳腺病灶，或临床疑有隐匿性乳腺癌行

F-FDG PET/CT检查的患者，在知情同意下进行乳腺专用PET复查，测定最大标准摄取值(SUVmax)。采用独立样本t检验比较不同病灶大小、超声分级、分子亚型之间SUVmax的差异。

结果：

最终获得病理并纳入分析48例，专用PET检出病灶63个，最小病灶约0.3 cm。恶性病灶长径1 cm、1~2 cm和2 cm时，SUVmax平均值分别为4.582.01、7.513.10和11.275.29，两两比较差异均有统计学意义(

0.01或

0.05)；乳腺影像报告和数据系统(BI-RADS)4级与5级之间SUVmax差异也有统计学意义(

0.05)；各分子亚型之间SUVmax差异无统计学意义。

结论：

乳腺专用PET对探测乳腺小病灶、多中心、多原发病灶具有很好的临床应用价值。

Abstract

Objective:

To evaluate the preliminary clinical application value of MAMMI dedicated breast PET.

Methods:

A total of 76 patients with positive breast lesions on whole-body

F-fluorodeoxyglucose (18F-FDG) PET/CT or suspicious occult breast cancer voluntarily underwent MAMMI PET in prone position after whole-body

F-FDG PET/CT. The maximal standardized uptake values (SUVmax) were compared according to lesion size

ultrasound grading and molecular subtype of breast cancer.

Results:

MAMMI PET visualized 63 lesions in 48 patients with specific pathologic diagnosis. The smallest lesion was 0.3 cm indiameter. Malig

nant lesions were classified into 3 groups based on diameter as follows: grade 1

1 cm or smaller; grade 2

1 to 2 cm; and grad 3

larger than 2 cm. The mean values of SUVmax of them were 4.58 2.01

7.51 3.10 and 11.275.29

respectively

and there were significant differences in SUVmax through pairwise comparison (

0.01 or

0.05). Difference in SUVmax was also observed between Breast Imaging Reporting and Data System (BI-RADS) grade 4 and grade 5 (

0.05). But there were no significant differences among different molecular subtypes.

Conclusion:

MAMMI PET has a promising clinical value in detecting small

multicenter and multiple primary breast lesions.

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