Relationship among MR apparent diffusion coefficiency, tumor size and Ki-67 expression in non-mass-like breast carcinoma

XU Maolin; LI Fang; SU Danke; XIE Dong; JIN Guanqiao; HUANG Xiangyang; LAI Shaolv

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Relationship among MR apparent diffusion coefficiency, tumor size and Ki-67 expression in non-mass-like breast carcinoma

更新时间：2026-06-18

- Relationship among MR apparent diffusion coefficiency, tumor size and Ki-67 expression in non-mass-like breast carcinoma
- Vol. 24, Issue 3, Pages: 212-215(2015)
- 作者机构：
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  CLC：
- Online First：20 October 2015，
  
  Published：20 October 2015
- 稿件说明：
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徐茂林,李芳,苏丹柯,等. 非肿块型乳腺癌的MR表观扩散系数及肿瘤大小与Ki-67表达的相关性研究[J]. 肿瘤影像学, 2015, 24(3): 212-215
DOI：

徐茂林,李芳,苏丹柯,等. 非肿块型乳腺癌的MR表观扩散系数及肿瘤大小与Ki-67表达的相关性研究[J]. 肿瘤影像学, 2015, 24(3): 212-215 DOI：

摘要

目的：

探讨非肿块型乳腺癌MR扩散加权成像(DWI)表观扩散系数(ADC)及肿瘤大小与Ki-67表达的相关性。

方法：

收集经病理证实的乳腺癌患者80例，术前行MRI检查，且动态增强均表现为非肿块样强化。测定病灶的ADC值及肿瘤大小，应用免疫组化染色测定Ki-67的表达情况，应用t检验、Spearman秩相关分析病灶的ADC值及肿瘤大小与Ki-67表达的相关性，应用受试者工作特征(ROC)曲线分析获得诊断Ki-67阳性表达的最佳肿瘤大小阈值。

结果：

Ki-67阳性组ADC值为(1.0140.181)10

-3

/s，阴性组ADC值为(1.0240.142)10

-3

/s；Ki-67阳性组肿瘤大小为(5.121.71) cm，阴性组肿瘤大小为(3.580.89) cm。Ki-67阳性组与阴性组肿瘤大小差异有统计学意义(

=4.741，

＜0.05)，且肿瘤大小与Ki-67的阳性表达呈正相关(

=0.366，

＜0.05)。ROC曲线分析显示，判断Ki-67表达的最佳肿瘤大小阈值为4.1 cm，灵敏度和特异度分别为68.66%和84.62%。但Ki-67阳性组与阴性组ADC值差异无统计学意义(

=-0.189，

＞0.05)，且ADC值与Ki-67表达无明显相关性(

=-0.029，

＞0.05)。

结论：

肿瘤大小与Ki-67的表达有一定的相关性，可间接为非肿块型乳腺癌的临床治疗及预后评估提供参考依据。

Abstract

Objective:

To investigate the relationship among MR apparent diffusion coefficiency (ADC)

tumor size and Ki-67 expression in non-mass-like breast carcinoma.

Methods:

A total of 80 cases diagnosed as breast cancers by pathologic examination underwent MRI prior to surgery. All cases showed non-mass-like enhancemen

t in dynamic contrast-enhanced MRI. ADC value and tumor size were measured respectively. The expression of Ki-67 in tumor tissue was assayed by immunohistochemical staining. t test and Spearman rank correlation were used to evaluate the correlation among ADC value

tumor size and Ki-67 expression. The receiver operating characteristic (ROC) curve was applied to get the best threshold of tumor size to judge Ki-67 expression.

Results:

The ADC values in Ki-67 positive and negative groups were (1.0140.181)10

-3

/s and (1.0240.142)10

-3

respectively. The tumor sizes in Ki-67 positive and negative expression groups were (5.121.71) cm and (3.580.89) cm

respectively. There was significant difference in tumor size between Ki-67 positive and negative groups (

=4.741

＜0.05)

and the tumor size was positively correlated with Ki-67 expression

=0.366

＜0.05). The best threshold of tumor size to judge Ki-67 expression was 4.1 cm by ROC curve. However

there was no significant difference in ADC value between Ki-67 positive and negative groups (

=-0.189

＞0.05)

and ADC value was not correlated with Ki-67 expression (

=-0.029

＞0.05).

Conclusion:

Tumor size may be correlated with Ki- 67 expression in non-mass-like breast carcinoma

and formulate the treatment and it can help to prognosis evaluation for patients.

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