Correlation of ultrasound radiomics features with invasive proteins in lymph node metastasis of papillary thyroid carcinoma

ZHOU Shichong; TONG Yuyang; HUANG Yunxia; LIU Tongtong; ZHOU JIN; YU Jinhua; GUO Yi; WANG Yuanyuan; LI Jiawei; CHANG Cai; CHEN Min

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Correlation of ultrasound radiomics features with invasive proteins in lymph node metastasis of papillary thyroid carcinoma

更新时间：2026-06-18

- Correlation of ultrasound radiomics features with invasive proteins in lymph node metastasis of papillary thyroid carcinoma
- Vol. 27, Issue 2, Pages: 65-69(2018)
- 作者机构：
  
  1. 复旦大学附属肿瘤医院超声诊断科，复旦大学上海医学院肿瘤学系,上海,200032
  2. 上海市医学图像处理与计算机辅助手术重点实验室,上海,200433
  3. 复旦大学电子工程系,上海,200433
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：16 May 2018，
  
  Published：16 May 2018
- 稿件说明：
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周世崇,童宇洋,黄云霞,等. 甲状腺乳头状癌淋巴结转移的超声影像组学特征与侵袭性蛋白质的相关性[J]. 肿瘤影像学, 2018, 27(2): 65-69
DOI：

周世崇,童宇洋,黄云霞,等. 甲状腺乳头状癌淋巴结转移的超声影像组学特征与侵袭性蛋白质的相关性[J]. 肿瘤影像学, 2018, 27(2): 65-69 DOI：

摘要

目的：

探索超声影像组学评估甲状腺乳头状癌淋巴结转移系统与侵袭性蛋白质的关系。

方法：

通过已有影像组学系统，选择于复旦大学附属肿瘤医院手术的30例甲状腺乳头状癌患者进行淋巴结转移预测，并获取病灶组织，通过蛋白质质谱分析筛选侵袭性蛋白质，用Person统计法分析超声影像组学特征与蛋白质表达之间的相关性。

结果：

超声影像组学预测淋巴结转移的准确率为96.7%。4种蛋白质与19项特征呈极强相关，5种蛋白质与23项特征呈强相关。

结论：

甲状腺乳头状癌淋巴结转移系统的超声影像组学特征与病灶组织侵袭性蛋白质相关。

Abstract

Objective:

To explore the relationship between ultrasound radiomics features and invasive proteins in metastasis of papillary thyroid carcinoma (PTC).

Methods:

Thirty cases of PTC in Fudan University Shanghai Cancer Center were selected. Ultrasound radiomics prediction system was used to predict lymph node metastasis. All lesion tissues were analyzed by protein spectrum and screened to obtain invasive proteins. The correlation between radiomics features with protein expressions was analyzed by Pearson correlation coefficient.

Results:

The accuracy of lymph node metastasis predicted by radiomics was 96.7%. There were 4 proteins extremely strongly correlated with 19 radiomics features

5 proteins strongly correlated with 23 radiomics features.

Conclusion:

There is a correlation between ultrasound radiomics features with invasive proteins in lymph node metastasis of PTC.

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Related Institution

Department of Thyroid and Breast Surgery, The First People’s Hospital of Jintan

Department of Ultrasound, The Second People’s Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University

Department of Internal Medicine, Yixing Sixth People's Hospital

Department of Ultrasound, Maoming People's Hospital

Department of Ultrasound, The First Hospital of Qinhuangdao

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