Evaluation of <sup>99m</sup>Tc-hydrazinonicotinamide-Tyr3-octreotide SPECT/CT in detection of colorectal neuroendocrine neoplasms

LI Yi; XU Junyan; XU Xiaoping; ZHANG Jiangang; MA Guang; HU Silong; PAN Herong; CHENG Jingyi; ZHANG Yingjian

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Evaluation of ^99mTc-hydrazinonicotinamide-Tyr3-octreotide SPECT/CT in detection of colorectal neuroendocrine neoplasms

更新时间：2026-06-18

- Evaluation of ^99mTc-hydrazinonicotinamide-Tyr3-octreotide SPECT/CT in detection of colorectal neuroendocrine neoplasms
- Vol. 26, Issue 1, Pages: 67-71(2017)
- 作者机构：
  
  1. 复旦大学附属肿瘤医院核医学科，复旦大学上海医学院肿瘤学系,上海,200032
  2. 复旦大学生物医学影像研究中心,上海,200032
  3. 上海市质子重离子医院核医学科,上海,201315
  4. 上海分子影像探针工程技术研究中心,上海,200032
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：13 April 2017，
  
  Published：13 April 2017
- 稿件说明：
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李毅,徐俊彦,许晓平,等. ⁹⁹mTc-HYNIC-TOC SPECT/CT显像探测结直肠神经内分泌肿瘤的临床价值[J]. 肿瘤影像学, 2017, 26(1): 67-71
DOI：

李毅,徐俊彦,许晓平,等. ⁹⁹mTc-HYNIC-TOC SPECT/CT显像探测结直肠神经内分泌肿瘤的临床价值[J]. 肿瘤影像学, 2017, 26(1): 67-71 DOI：

摘要

目的：

探讨

99m

Tc标记肼基烟酰胺奥曲肽类似物(

99m

Tc-hydrazinonicotinyl-Tyr3-octreotide，

99m

Tc-HYNICTOC)显像探测结直肠神经内分泌肿瘤(neuroendocrine neoplasm，NEN)的价值。

方法：

对122例行

99m

Tc-HYNIC-TOC显像的结直肠NEN患者进行回顾性分析，其中原发灶位于阑尾26例、直肠90例、乙状结肠3例、横结肠2例、降结肠1例。静脉注射370~555 MBq

99m

Tc-HYNIC-TOC 2 h后，全身平面显像，随后行腹盆部SPECT/CT断层显像，对各个病灶进行图像分析，测量靶/非靶放射性计数比值(target/non-target，T/NT)，病灶判断以临床治疗和随访结果为金标准。

结果：

99m

Tc-HYNICTOC对结直肠NEN的灵敏度、特异度和准确率分别为93.2%、97.4%和95.9%。病灶检出率为89.2%(199/223)，阳性病灶T/NT平均值为14.39.7(1.3~37.9，

=199)，G1与G3、G2与G3级阳性率比较差异均有统计学意义(

=10.906，

=0.001；

=19.775，

0.001)。此外，SPECT/CT断层配合全身平面显像可更加准确地发现病灶，对结直肠NEN患者术前评估及疗效评价均有较好的应用价值。

结论：

99mTc-HYNIC-TOC显像可准确、灵敏地探测结直肠NEN。

Abstract

Objective:

To evaluate the value of

99m

Tc-hydrazinonicotinyl-Tyr3-octreotide (

99m

Tc-HYNIC-TOC) in thedetection of colorectal neuroendocrine neoplasms.

Methods:

99m

Tc-HYNIC-TOC imaging data of 122 patients with colorectal neuroendocri

ne neoplasms were analyzed retrospectively

including 26 in appendix

90 in rectum

3 in sigmoid colon

2 in transverse colon

1 in descending colon. Whole-body imaging and SPECT/CT imaging were obtained 2 h after intravenous injection of 370- 555 MBq

99m

Tc-HYNIC-TOC.

Results:

The sensitivity

specificity

accuracy of

99m

Tc-HYNIC-TOC SPECT/CT were 93.2%

97.4%

95.9%. The detection rate for all the lesions was 89.2% (199/223). The average target/non-target (T/NT) value of positive lesions was 14.39.7 (1.3-37.9

=199). Poorly differentiated colorectal neuroendocrine neoplasm

had lower imaging positive rate than G1 (

=10.906

=0.001) and G2 (

=19.775

0.001). Besides

SPECT/CT scan could provide more correct information than planar imaging.

Conclusion:

99m

Tc-HYNIC-TOC SPECT/CT is an excellent method for detection of colorectal neuroendocrine neoplasms.

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Evaluation of 99mTc-hydrazinonicotinamide-Tyr3-octreotide SPECT/CT in detection of colorectal neuroendocrine neoplasms

DOI：

摘要

Abstract

关键词

Keywords

references

Evaluation of ^99mTc-hydrazinonicotinamide-Tyr3-octreotide SPECT/CT in detection of colorectal neuroendocrine neoplasms