Contrast-enhanced ultrasonography (CEUS) characteristics of hepatic neuroendocrine neoplasm (hNEN) correlation with pathological grade

WANG Hantao; WANG Wenping; ZHANG Xiaolong; XU Yadan; ZHANG Weibin; HAN Hong; ZHU Zheng; DONG Yi

doi:10.19401/j.cnki.1007-3639.2018.03.002

您当前的位置：

首页 >

文章列表页 >

Contrast-enhanced ultrasonography (CEUS) characteristics of hepatic neuroendocrine neoplasm (hNEN) correlation with pathological grade

更新时间：2025-12-15

- Contrast-enhanced ultrasonography (CEUS) characteristics of hepatic neuroendocrine neoplasm (hNEN) correlation with pathological grade
- Vol. 27, Issue 3, Pages: 134-139(2018)
- 作者机构：
  
  1. 复旦大学附属中山医院超声科,上海,200032
  2. 上海市影像医学研究所,上海,200032
  3. 江苏太仓市第一人民医院，江苏太仓,215400
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2018.03.002
  CLC：
- Published Online：26 July 2018，
  
  Published：26 July 2018
- 稿件说明：
移动端阅览
汪瀚韬,王文平,张小龙,等. 肝脏神经内分泌肿瘤的超声造影表现及与病理分级的对照研究[J]. 肿瘤影像学, 2018, 27(3): 134-139 https://doi.

org/10.19401/j.cnki.1007-3639.2018.03.002
汪瀚韬,王文平,张小龙,等. 肝脏神经内分泌肿瘤的超声造影表现及与病理分级的对照研究[J]. 肿瘤影像学, 2018, 27(3): 134-139 https://doi. DOI： 10.19401/j.cnki.1007-3639.2018.03.002.

org/10.19401/j.cnki.1007-3639.2018.03.002 DOI：

摘要

目的：

分析肝脏神经内分泌肿瘤的超声造影表现特征，探讨超声造影对肝脏神经内分泌肿瘤的诊断价值及病理分级预测价值。

方法：

选取2009年9月2017年9月就诊于复旦大学附属中山医院的34例肝脏神经内分泌肿瘤患者，其中25例由肝脏穿刺活检或手术病理证实，9例由原发灶病理结合增强CT/MRI检查证实。所有患者术前均行超声造影检查。根据病理结果，参照世界卫生组织（World Health Organization，WHO）2010年消化系统神经内分泌肿瘤分级标准，将肿瘤病理分级分为G1、G2和G3级。G2与G3级病灶间定量指标的比较采用独立样本

检验或Mann-Whitney

检验，定性指标的比较采用Fisher精确概率法。

结果：

34例肝脏神经内分泌肿瘤病理分级为G1级0例，G2级21例，G3级13例；病灶平均开始增强时间、达峰时间、消退时间分别为（16.24.7）、（22.05.5）和（42.923.4）s；在动脉期增强过程中，79.4%（27/34）的病灶表现为整体增强，20.6%（7/34）的病灶表现为向心性增强；增强达峰时，61.8%（21/34）的病灶呈均匀增强，26.5%（9/34）的病灶呈不均匀增强，11.8%（4/34）的病灶呈环形增强；门静脉期，所有病灶均表现出不同程度的减退，其中32.3%（11/34）的病灶呈轻度减退，67.7%（23/34）的病灶呈明显减退；延迟期所有病灶均呈明显减退。与肝实质增强情况相比，病灶的增强-减退模式可表现为快进快出、同进快出及慢进快出3种。其中52.9%（18/34）的病灶呈快进快出，38.3%（13/34）的病灶呈同进快出，8.8%（3/34）的病灶呈慢进快出。G2与G3级病灶间增强-减退模式的差异有统计学意义（

＜0.05），而增强时间、增强方式、峰值表现和减退程度的差异无统计学意义（

＞0.05）。

结论：

肝脏神经内分泌肿瘤的超声造影表现具有一定特征，病灶的增强-减退模式对肝脏神经内分泌肿瘤病理分级的预测有一定价值。

Abstract

Objeative:

To analyze the contrast-enhanced ultrasonography (CEUS) characteristic

s of hepatic neuroendocrine neoplasm (hNEN) and to investigate its clinical values of CEUS in predicting pathological grading of hNEN.

Methods:

From Sep. 2009 to Sep. 2017

images of CEUS were analyzed retrospectively in 34 cases of hNEN confirmed by pathology and imaging in Zhongshan Hospital

Fudan University. The CEUS characteristics including enhancement time

enhancement pattern

manifestations of peak time

washout degree of enhancement and wash in-wash out model of lesions were observed by two ultrasound doctors who had at least five-year working experience. These 34 cases were divided into 3 grades（G1

G2 and G3）according to World Health Organization 2010 classification of gastroenteropancreatic NEN. The differences in CEUS characteristics among deifferent grades were compared.

Results:

The average time to start

time to peak and time to decline were (16.24.7)

(22.05.5) and (42.923.4) s respectively. Two patterns of enhancement were observed during the enhancement progression: global enhancement and centripetal enhancement. Of the 34 hNEN cases

79.4% (27/34) of lesions showed global enhancement and 20.6% (7/34) of lesions showed centripetal enhancement. As for the manifestations of peak time

61.8% (21/34) of lesions showed homogenously enhanced pattern

while 26.5% (9/34) of lesions showed inhomogenously enhanced pattern and 11.8% (4/34) of lesions showed rim-like enhanced pattern. The enhancement of all lesions washed out at portal venous phase with different degree. Of the 34 hNEN cases

32.3% (11/34) of leisons showed mild washout and 67.7% (23/34) of lesions showed remarkable washout. All lesions showed remarkable washout at delay phase. Compared with liver parenchyma

52.9% (18/34) of hNEN lesions showed fast in and fast out

38.3% (13/34) of hNEN lesions showed synchronous in and fast out and 8.8% (3/34) of hNEN lesions showed slow in and fast out. A greater percentage of fast in and fast out was found in G2 lesions (76.2%

16/21) than in G3 lesions (15.4%

2/13)

with statistical significance (

＜0.05）.

Conclusion:

CEUS can provide useful information in diagnosing hNEN. The wash in-wash out model of CEUS may preoperatively predict the pathological grading of hNEN.

关键词

Keywords

references

Views

1609

下载量

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

The feature analysis of ⁶⁸ Ga-somatostatin analogue PET/CT for bone metastasis of neuroendocrine neoplasm

CT and MRI features of pancreatic neuroendocrine neoplasm

Research status and progress of ultrasound on pancreatic neuroendocrine neoplasm

Evaluation of ^99mTc-hydrazinonicotinamide-Tyr3-octreotide SPECT/CT in detection of colorectal neuroendocrine neoplasms

Related Author

SONG Shaoli

XU Xiaoping

XU Junyan

ZENG Mengsu

YAO Xiuzhong

JI Yuan

WANG Mingliang

DONG Yi

Related Institution

Shanghai Engineering Research Center of Molecular Imaging Probes

Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University

Center for Biomedical Imaging, Fudan University

Department of Radiology, Zhongshan Hospital, Fudan University

Department of Pathology, Zhongshan Hospital, Fudan University

AI问答

⁰