Clinical value of contrasted-enhanced ultrasound in diagnosis of pancreatic neuroendocrine tumors

YANG Daohui; ZHANG Qi; YU Lingyun; DONG Yi; CAO Jiaying; MAO Feng; WANG Wenping

doi:10.19401/j.cnki.1007-3639.2018.03.004

您当前的位置：

首页 >

文章列表页 >

Clinical value of contrasted-enhanced ultrasound in diagnosis of pancreatic neuroendocrine tumors

更新时间：2025-12-15

- Clinical value of contrasted-enhanced ultrasound in diagnosis of pancreatic neuroendocrine tumors
- Vol. 27, Issue 3, Pages: 145-149(2018)
- 作者机构：
  
  1. 复旦大学附属中山医院超声科,上海,200032
  2. 上海市影像医学研究所,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2018.03.004
  CLC：
- Published Online：26 July 2018，
  
  Published：26 July 2018
- 稿件说明：
移动端阅览
杨道辉,张琪,于凌云,等. 超声造影诊断胰腺神经内分泌肿瘤的临床应用价值[J]. 肿瘤影像学, 2018, 27(3): 145-149 https://doi.

org/10.19401/j.cnki.1007-3639.2018.03.004
杨道辉,张琪,于凌云,等. 超声造影诊断胰腺神经内分泌肿瘤的临床应用价值[J]. 肿瘤影像学, 2018, 27(3): 145-149 https://doi. DOI： 10.19401/j.cnki.1007-3639.2018.03.004.

org/10.19401/j.cnki.1007-3639.2018.03.004 DOI：

摘要

目的：

胰腺神经内分泌肿瘤（pancreatic neuroendocrine tumors，pNET）在临床上较罕见，本研究对比分析pNET病灶与胰腺导管腺癌（pancreatic ductal adenocarcinoma，PDAC）的超声造影（contrastenhanced ultrasound，CEUS）表现，旨在揭示CEUS在pNET术前诊断及鉴别诊断中的价值。

方法：

回顾性分析了18例pNET患者共18个病灶常规超声及超声造影的增强方式和特点，并与55例PDAC病灶相比较。所有的病灶都经手术及病理证实。

结果：

pNET病灶平均大小为（36.618.1）mm，PDAC病灶平均大小为（37.115.2）mm。注射超声造影剂后，所有pNET在动脉期均表现为高增强（

=11，61.1%）或等增强（

=7，38.9%）；静脉期pNET病灶多表现为高增强（33.3%，6/18）或等增强（50.0%，9/18）。延迟期27.8%（5/18）的病灶表现为高增强，50.0%（9/18）的病灶表现为等增强。而多数（76.4%）PDAC病灶始终表现为不均匀低增强（

0.05）。超声造影诊断pNET的符合率为94.4%，灵敏度、特异度、准确度、阳性预测值及阴性预测值分别为77.8%、100.0%、94.5%、100.0%和93.1%。

结论：

CEUS有助于术前诊断及鉴别诊断pNET。

Abstract

Objective:

Pancreatic neuroendocrine tumors (pNET) are very rare in clinic. In our retrospective study

the contrast-enhanced ultrasound (CEUS) features of pNET and pancreatic ductal adenocarcinoma (PDAC) were compared to evaluate the preoperative diagnosis value of CEUS.

Methods:

In our retrospective study

18 cases of pNET patients (18 lesions) and 55 cases of PDA

C patients (55 lesions) were included. Ultrasound and CEUS imaging features were investigated and compared. All the lesions were final proved by operation and histopathological results.

Results:

On conventional grayscale ultrasound

the average diameter of pNET lesions was (36.618.1) mm

and (37.115.2) mm for PDAC lesions. After injection of contrast agents

all pNET lesions showed hyper-enhancement (

=11

61.1%) or iso-enhancement (

38.9%) during arterial phase

33.3% (6/18) lesions showed hyper-enhancement and 50.0% (9/18) lesions showing iso-enhancement during venous phase. About 27.8% (5/18) lesions showed hyperenhancement and 50.0%(9/18) lesions showed iso-enhancement during late phase. However

most (76.4%) PDAC lesions showed hypo enhancement during all CEUS phases (

0.05). The diagnostic accuracy of CEUS in pNET was 94.4% (17/18)

with 77.8% sensitivity

100.0% specificity

94.5% accuracy

100% positive predictive value and 93.1% negative predictive value respectively.

Conclusion:

CEUS is helpful in preoperative diagnosis and differential diagnosis of pNET.

关键词

Keywords

references

Views

1733

下载量

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Advances of contrast-enhanced ultrasound in diagnosing application of testicular neoplasms

Application of contrast-enhanced ultrasound in differential diagnosis of benign and malignant breast tumors

Analysis of thyroid nodules by contrast-enhanced ultrasound

The contrast-enhanced ultrasonographic appearances of focal liver lesions

A preliminary study on the application of Sonazoid contrast-enhanced ultrasound in improving the detection rate of liver nodules

Related Author

YU Jie

DU Lianfang

LI Fan

WANG Jing

SHI Qiusheng

LI Gang

WU Rong

OU Shengsheng

Related Institution

Department of Ultrasound, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University

Department of Ultrasonography, Lanzhou University Second Hospital

Department of Ultrasound, Putuo Hospital, Shanghai University of Traditional Chinese Medicine

Department of Ultrasound, Zhongshan Hospital of Fudan University

Department of Ultrasound, Zhongshan Hospital (Xiamen Branch), Fudan University

AI问答

⁰