Correlation between imaging features and immunohistochemical results in breast cancer

DU Lijuan; YANG Pei

doi:10.19401/j.cnki.1007-3639.2018.03.017

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Correlation between imaging features and immunohistochemical results in breast cancer

更新时间：2025-12-15

- Correlation between imaging features and immunohistochemical results in breast cancer
- Vol. 27, Issue 3, Pages: 215-218(2018)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.19401/j.cnki.1007-3639.2018.03.017
  CLC：
- Published Online：26 July 2018，
  
  Published：26 July 2018
- 稿件说明：
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杜丽娟,杨培. 乳腺癌影像学表现与分子亚型的相关性探索[J]. 肿瘤影像学, 2018, 27(3): 215-218 https://doi.

org/10.19401/j.cnki.1007-3639.2018.03.017
杜丽娟,杨培. 乳腺癌影像学表现与分子亚型的相关性探索[J]. 肿瘤影像学, 2018, 27(3): 215-218 https://doi. DOI： 10.19401/j.cnki.1007-3639.2018.03.017.

org/10.19401/j.cnki.1007-3639.2018.03.017 DOI：

摘要

目的：

探讨乳腺癌的X线表现、MRI征象与各分子亚型的关系。

方法：

回顾性分析2015年6月2017年8月郑州大学附属郑州中心医院收治并经手术病理证实的91例乳腺癌的X线表现、MRI征象及免疫组织化学检查结果。

结果：

Luminal A型单纯肿块及肿块合并钙化比例为76.5%（26/34），MRI肿块样强化比例为70.6%（24/34）。Luminal B型单纯肿块及肿块合并钙化比例为55.6%（10/18），不对称和结构扭曲比例为27.8%（5/18）。人表皮生长因子受体2（human epidermal growth factor receptor 2，HER-2）过表达型X线显示钙化比例为91.3%（21/23），MRI非肿块样强化比例为78.3%（18/23）。三阴性乳腺癌X线显示单纯肿块及肿块合并钙化比例为93.8%（15/16），MRI上此15例均为肿块样强化，无一例表现为单纯钙化。动态增强曲线类型与免疫组织化学亚型无相关性（

＞0.05）。

结论：

乳腺癌各分子亚型影像学表现不同，影像学表现分析对乳腺癌的临床治疗及预后评估有一定价值。

Abstract

Objective:

To investigate the relationship between mammographic findings

MRI features and molecular subtypes of breast cancer.

Methods:

The mammographic findings

MRI features and immunohistochemical results of 91 breast cancer patients (hospitalized from Jun. 2015 to Aug. 2017) confirmed by surgical pathology were retrospectively reviewed.

Results:

The ratio of mass-type and mass-type complicated with calcification in Luminal A type breast cancer was 76.5% (26/34)

and MRI showed mass enhancemen

t in 70.6% (24/34) lesions. In Luminal B type breast cancer

the ratio of mass-type and mass-type complicated with calcification was 55.6% (10/18)

and the ratio of asymmetries and architectural distortion was 27.8% (5/18). In human epidermal growth factor receptor 2 (HER-2) overexpression type breast cancer

mammography showed calcification in 91.3% (21/23) lesions

and MRI showed nonmass enhancement in 78.3% (18/23) lesions. The ratio of mass-type and mass-type complicated with calcification was 93.8% (15/16) in triple negative breast cancer on MRI

and there was no pure calcification. There was no correlation between dynamic enhancement curve and clinicopathologic characteristics (

0.05).

Conclusion:

Different molecular subtypes of breast cancer have different imaging features. The analysis of imaging features has some values in clinical treatment and prognosis evaluation.

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