Correlation between standardized uptake value on <sup>18</sup>F-fluorodeoxyglucose PET/CT and apparent diffusion coefficient in the patients with nasopharyngeal carcinoma

XIAO Jingxing; LUO Zebin; CHEN Xiaodong; WANG Dong

doi:10.19732/j.cnki.1008-617X.2018.04.013

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Correlation between standardized uptake value on ¹⁸F-fluorodeoxyglucose PET/CT and apparent diffusion coefficient in the patients with nasopharyngeal carcinoma

更新时间：2025-12-15

- Correlation between standardized uptake value on ¹⁸F-fluorodeoxyglucose PET/CT and apparent diffusion coefficient in the patients with nasopharyngeal carcinoma
- Vol. 27, Issue 4, Pages: 313-318(2018)
- 作者机构：
  
  1. 广东医科大学附属医院核医学科,广东,湛江,524038
  2. 广东医科大学附属医院放射科,广东,湛江,524038
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.1008-617X.2018.04.013
  CLC：
- Published Online：17 September 2018，
  
  Published：17 September 2018
- 稿件说明：
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肖景兴,罗泽斌,陈晓东,等. 鼻咽癌¹⁸F-FDG PET/CT标准摄取值与表观扩散系数的相关性分析[J]. 肿瘤影像学, 2018, 27(4): 313-318 https://doi.

org/10.19732/j.cnki.1008-617X.2018.04.013
肖景兴,罗泽斌,陈晓东,等. 鼻咽癌¹⁸F-FDG PET/CT标准摄取值与表观扩散系数的相关性分析[J]. 肿瘤影像学, 2018, 27(4): 313-318 https://doi. DOI： 10.19732/j.cnki.1008-617X.2018.04.013.

org/10.19732/j.cnki.1008-617X.2018.04.013 DOI：

摘要

目的：

该研究旨在探讨鼻咽癌

F-脱氧葡萄糖（

F-fluorodeoxyglucose，

F-FDG）PET/CT最大标准摄取值（maximum standardized uptake value，SUV

max

）和磁共振扩散加权成像（diffusion weighted imaging，DWI）最小表观扩散系数（minimum apparent diffusion coefficient，ADCmin）的相关性，同时分别探讨这两个参数在鼻咽癌T

1-2

与T

3-4

患者之间的差异是否有统计学意义。

方法：

回顾性分析27例放化疗前同时行

F-FDG PET/CT和头颈部DWI-磁共振成像（magnetic resonance imaging，MRI）检查的鼻咽癌患者的图像资料。勾画感兴趣区（region of interest，ROI），测量病灶SUVmax和ADCmin，对这两个参数进行Spearman相关性分析。采用独立样本t检验对T

1-2

与T

3-4

患者SUV

max

进行统计学分析，比较T

1-2

与T

3-4

组ADCmin的差异。

结果：

鼻咽癌SUV

max

（9.124.01）与ADCmin ［（0.6740.186）10

-3

/s］之间无相关关系（

=-0.031，

=0.876）。T

1-2

与T

3-4

组鼻咽癌病灶的SUV

max

差异有统计学意义（

＜0.001），且T3-4组病灶的SUV

max

高于T

1-2

组。T

1-2

与T

3-4

组鼻咽癌病灶的ADCmin差异无统计学意义（

=0.798）。

结论：

鼻咽癌

F-FDG PET/CT的SUVmax和DWI的ADCmin是相互独立的生物学参数，这些诊断技术可能在诊断、评估鼻

咽癌等方面发挥补充作用。SUV

max

可在一定程度上反映鼻咽癌的T分期。

Abstract

Objective:

To prospectively assess the correlation between maximum standardized uptake value (SUV

max

) and minimum apparent diffusion coefficient (ADCmin) in the patients with nasopharyngeal carcinoma

and to investigate the differences in SUV

max

and ADCmin between T

1-2

and T

3-4

Methods:

A total of 27 nasopharyngeal carcinoma patients were chosen. They all underwent 18F-fluorodeoxyglucose (18F-FDG) PET/CT scanning and head and neck 3T magnetic resonance imaging (MRI) diffusion weighted imaging (DWI) before chemotherapy. Spearmans test was used to calculate the correlation between SUVmax and ADCmin. Independent sample t-test was used to assess the differences in SUVmax and ADCmin between T

1-2

and T

3-4

Results:

SUV

max

(9.124.01) was not correlated with ADCmin [(0.6740.186)10

-3

]

in nasopharyngeal carcinoma patients (

=-0.031

=0.876). T3-4 group had higher SUV

max

than T

1-2

group (

0.001). The ADCmin value between the two groups was not significantly different (

=0.798).

Conclusion:

It is suggested that SUV

max

and ADCmin are independent biomarkers in nasopharyngeal carcinoma. SUV

max

could reflect T staging of nasopharyngeal carcinoma to a certain extent.

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Correlation between standardized uptake value on 18F-fluorodeoxyglucose PET/CT and apparent diffusion coefficient in the patients with nasopharyngeal carcinoma

DOI：10.19732/j.cnki.1008-617X.2018.04.013

摘要

Abstract

关键词

Keywords

references

Correlation between standardized uptake value on ¹⁸F-fluorodeoxyglucose PET/CT and apparent diffusion coefficient in the patients with nasopharyngeal carcinoma