Diagnostic value of magnetic resonance diffusion kurtosis imaging in prostate cancer: Metaanalysis

LI Hongwei; JIANG Xiaofeng; WANG Lang; LIU Chuan; WANG Yao; XU Xiaoxue; YANG Hanfeng; DU Yong

doi:10.19732/j.cnki.1008-617X.2018.04.015

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Diagnostic value of magnetic resonance diffusion kurtosis imaging in prostate cancer: Metaanalysis

更新时间：2025-12-15

- Diagnostic value of magnetic resonance diffusion kurtosis imaging in prostate cancer: Metaanalysis
- Vol. 27, Issue 4, Pages: 322-328(2018)
- 作者机构：
  
  1. 川北医学院附院医院放射科,四川,南充,637000
  2. 绵阳市第三人民医院放射科,四川,绵阳,621000
  3. 南部县中医医院放射科,四川,南充,637399
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.1008-617X.2018.04.015
  CLC：
- Published Online：17 September 2018，
  
  Published：17 September 2018
- 稿件说明：
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李宏伟,蒋小凤,王朗,等. 磁共振扩散峰度成像对前列腺癌诊断价值的Meta分析[J]. 肿瘤影像学, 2018, 27(4): 322-328 https://doi.

org/10.19732/j.cnki.1008-617X.2018.04.015
李宏伟,蒋小凤,王朗,等. 磁共振扩散峰度成像对前列腺癌诊断价值的Meta分析[J]. 肿瘤影像学, 2018, 27(4): 322-328 https://doi. DOI： 10.19732/j.cnki.1008-617X.2018.04.015.

org/10.19732/j.cnki.1008-617X.2018.04.015 DOI：

摘要

目的：

采用Meta分析综合评价扩散峰度成像（diffusion kurtosis imaging，DKI）对前列腺癌的诊断价值，并定量分析前列腺癌组织与非癌组织的峰度系数（Kapp），为临床决策提供依据。

方法：

计算机检索PubMed、EMBASE、EBSCO、Cochrane Library、CNKI、CBM及维普数据库自建库以来至2017年7月31日国内外公开发表的关于DKI应用于前列腺癌诊断的中英文文献。由2名评价员根据纳入与排除标准独立筛选文献、提取资料，并采用QUADAS进行质量评价以及Meta-Disc 1.4和Stata 12.0软件进行Meta分析，提取相关参数。

结果：

共纳入符合标准文献7篇，患者总例数409例，感兴趣区804个，应用Q检验和I2值进行异质性分析发现文献无异质性，采用固定效应模型分析发现前列腺癌灶组织的Kapp值显著高于非癌组织（

=0.000）；合并灵敏度为0.943 [95%CI：0.915~0.962

]

，特异度为0.917 [95%CI：0.829~0.962

]

，阳性似然比为11.365 [95%CI：5.287~24.427

]

，阴性似然比为0.063 [95%CI：0.041~0.096

]

，诊断试验比值比(diagnostic odds ratio，DOR)为181.803 [95%CI：65.267~506.419

]

，受试者工作特征曲线的曲线下面积为0.96。

结论：

DKI对前列腺癌具有较高的诊断价值，且灵敏度、特异度较好。

Abstract

Objective:

To systematically review the diagnostic value of diffusion kurtosis imaging (DKI) in prostate cancer by meta-analysis

and to quantitatively analyze the kurtosis coefficient (Kapp) of prostate cancer tissue and non-cancerous tissue

so as to provide evidence-based basis for clinical decision-making.

Methods:

The database i

ncluding PubMed

EMBASE

EBSCO

Cochrane Library

CNKI

CBM

and VIP were electronically searched from inception to July 31

2017

to collect diagnostic articles about DKI in prostate cancer. Two reviewers independently screened the literatures

extracted data and assessed the methodological quality of included articles by QUADAS tool. Then

the relevant parameters were extracted by applying meta-Disc 1.4 and Stata 12.0 softwares.

Results:

A total of 7 articles met the inclusion criteria

409 patients were included

and the number of regions of interest was 804. The fixed effect model was used due to no heterogeneity. The results of Meta-analysis showed that Kapp value in prostate cancer tissue was significantly higher than that in non-cancerous tissue and the pooled sensitivity

specificity

positive likelihood ratio

negative likelihood ratio

and diagnostic odds ratio (DOR) were 0.943 [95%CI: 0.915-0.962

]

0.917 [95%CI: 0.829-0.962

]

11.365 [95%CI: 5.287-24.427

]

0.063 [95%CI: 0.041-0.096

]

181.803 [95%CI: 65.267-506.419

]

respectively

the area under the receiver operating characteristic curve was 0.96.

Conclusion:

DKI has a high value and good sensitivity and specificity in diagnosis of prostate cancer.

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