Clinical study of high frequency ultrasound combined with elastic strain rate ratio in diagnosis of breast cancer

SHI Haijian; DING Jie

doi:10.19732/j.cnki.1008-617X.2018.05.016

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Clinical study of high frequency ultrasound combined with elastic strain rate ratio in diagnosis of breast cancer

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- Clinical study of high frequency ultrasound combined with elastic strain rate ratio in diagnosis of breast cancer
- Vol. 27, Issue 5, Pages: 416-420(2018)
- 作者机构：
  
  1. 中国人民解放军第101 医院特诊科,江苏,无锡,214044
  2. 南京医科大学附属无锡市妇幼保健院超声科,江苏,无锡,214000
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.1008-617X.2018.05.016
  CLC：
- Published Online：14 November 2018，
  
  Published：14 November 2018
- 稿件说明：
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施海建,丁洁. 高频超声联合弹性应变率比值诊断乳腺癌的临床应用研究[J]. 肿瘤影像学, 2018, 27(5): 416-420 https://doi.

org/10.19732/j.cnki.1008-617X.2018.05.016
施海建,丁洁. 高频超声联合弹性应变率比值诊断乳腺癌的临床应用研究[J]. 肿瘤影像学, 2018, 27(5): 416-420 https://doi. DOI： 10.19732/j.cnki.1008-617X.2018.05.016.

org/10.19732/j.cnki.1008-617X.2018.05.016 DOI：

摘要

目的：

探讨高频超声联合弹性应变率比值（strain rate ratio，SRR）判断乳腺肿块良恶性的价值，并获取SRR最佳诊断值，为临床诊断提供参考。

方法：

回顾性分析2016年5月2017年4月期间因乳腺肿块于解放军第101医院就诊的65例患者共84个病灶。所有患者术前行高频超声及弹性成像检查，对肿块良恶性进行判断，并与手术后病理学检查结果对比。

结果：

高频超声诊断乳腺癌的灵敏度、特异度及准确率分别为78.4%、72.3%及75.0%。高频超声联合SRR，绘制受试者工作特征（receiver operating characteristic，ROC）曲线，曲线下面积（area under curve，AUC）为0.892时SRR最佳诊断值为3.01，诊断乳腺癌的灵敏度、特异度及准确率分别为91.9%、89.4%及90.5%。与高频超声联合SRR相比，高频超声单独诊断乳腺癌的灵敏度、特异度及准确率较低，特异度、准确率差异有统计学意义（

＜0.05），但灵敏度差异无统计学意义（

＞0.05）。

结论：

SRR是反映乳腺肿块硬度的重要指标，结合高频超声的二维灰阶图像特征、彩色多普勒超声血流动力学特征将提高乳腺癌的诊断率。

Abstract

Objective:

To investigate the value of high frequency ultrasound combined with elastic strain rate ratio (SRR) in the diagnosis of benign and malignant breast tumors

and to obtain the best diagnostic value of elastic SRR

so as to provide reference for clinical diagnosis.

Methods:

From May 2016 to April 2017

a total of 84 lesions in 65 patients with breast lesions were analyzed retrospectively. All cases were examined by high frequen

cy ultrasound and elastography before operation

and the benign and malignant tumors were judged and compared with the pathological results after operation.

Results:

The sensitivity

specificity and accuracy of high frequency ultrasonography in the diagnosis of breast cancer were 78.4%

72.3% and 75.0%

respectively. By using high frequency ultrasound combined with elastic SRR

receiver operating characteristic (ROC) curve was obtained. When the area under curve (AUC) was 0.892

the best diagnostic value of SRR was 3.01

and the accuracy

sensitivity and specificity of diagnosis of breast cancer were 91.9%

89.4%

90.5%. The sensitivity

specificity and accuracy of high frequency ultrasound alone were lower than those of combination of high frequency ultrasound and SRR in the diagnosis of breast cancer. The sensitivity was not significantly different (

0.05)

but the specificity and accuracy were significantly different (

0.05).

Conclusion:

SRR is an important index to reflect the hardness of breast lesions. Combination of two-dimensional image features of high frequency ultrasound and Doppler hemodynamic characteristics could improve the diagnostic rate of breast cancer.

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