Clinical role of PET/CT in distinguishing malignant from benign pleural effusion in non-small cell lung cancer&nbsp;

ZHANG Weishan; DUAN Xiaoyi; GUO Youmin; LI Yan; YANG Jian

doi:10.19732/j.cnki.2096-6210.2019.04.008

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Clinical role of PET/CT in distinguishing malignant from benign pleural effusion in non-small cell lung cancer

更新时间：2025-12-15

- Clinical role of PET/CT in distinguishing malignant from benign pleural effusion in non-small cell lung cancer
- Vol. 28, Issue 4, Pages: 248-253(2019)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2019.04.008
  CLC：
- Published Online：12 September 2019，
  
  Published：12 September 2019
- 稿件说明：
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张卫善,段小艺,郭佑民,等. PET/CT对非小细胞肺癌患者胸腔积液性质的鉴别诊断价值[J]. 肿瘤影像学, 2019, 28(4): 248-253 https://doi.

org/10.19732/j.cnki.2096-6210.2019.04.008
张卫善,段小艺,郭佑民,等. PET/CT对非小细胞肺癌患者胸腔积液性质的鉴别诊断价值[J]. 肿瘤影像学, 2019, 28(4): 248-253 https://doi. DOI： 10.19732/j.cnki.2096-6210.2019.04.008.

org/10.19732/j.cnki.2096-6210.2019.04.008 DOI：

摘要

目的：

探讨

F-FDG PET/CT鉴别初诊非小细胞肺癌（non-small cell lung cancer，NSCLC）患者中胸腔积液性质的临床价值。

方法：

回顾性分析合并胸腔积液的病理学确诊的初诊NSCLC患者，胸腔积液的良恶性诊断以胸腔穿刺及胸膜活检为标准。分别以胸膜标准化摄取值（standard uptake value，SUV）大于2.5、胸膜SUV大于动脉SUV为PET/CT诊断恶性胸腔积液的标准，计算其灵敏度、特异度、阳性预测值、阴性预测值和准确率。

结果：

共纳入46例患者，其中恶性胸腔积液患者39例。以胸膜SUV＞2.5为诊断标准，灵敏度、特异度、阳性预测值、阴性预测值和准确率分别为76.9%、100.0%、100.0%、43.8%和80.4%；以胸膜SUV＞动脉SUV为标准，分别为89.7%、100.0%、100.0%、63.6%和91.3%；二者受试者工作特征（receiver operating characteristic，ROC）曲线的曲线下面积分别为0.961和0.976。

结论：

F-FDG PET/CT对初诊NSCLC患者中胸腔积液的良恶性鉴别具有较高的临床价值。以胸膜核素浓聚程度高于纵隔为标准，可提高其诊断效能。

Abstract

Objective:

To explore the clinical role of 18 F-FDG PET/CT in distinguishing malignant from benign pleural effusion in pretreatment non-small cell lung cancer (NSCLC) patients.

Methods:

The NSCLC patients with pleural effusion who underwent PET/CT were retrospectively reviewed. Malignant or benign pleural effusion was confirmed with thoracentesis or biopsy. When the standard uptake value (SUV) of pleural was h

igher than 2.5 (SUV＞2.5) or pleural activity was higher than mediastinal background (pleural SUV＞aorta SUV)

pleural effusion was diagnosed as malignant. The sensitivity

specificity

positive predictive value

negative predictive value

and accuracy of PET/CT for detecting malignant pleural metastases were calculated.

Results:

Forty- six patients were enrolled

and 39 were malignant. For SUV＞2.5

the sensitivity

specificity

positive predictive value

negative predictive value

and accuracy of PET/CT were 76.9%

100.0%

43.8%

and 80.4%; and 89.7%

100.0%

63.6% and 91.3% for pleural SUV＞aorta SUV

respectively. The areas under curve of receiver operating characteristic (ROC) curve were 0.961 and 0.972

respectively.

Conclusion:

18 F-FDG PET/CT can play a significant role in distinguishing malignant from benign pleural effusion in pretreatment NSCLC patients. The diagnostic accuracy could be improved when pleural activity higher than mediastinal background that used as diagnostic criteria.

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