The effect of different injection locations of <sup>99m </sup>Tc-sulfur colloid for sentinel lymph node detection in breast cancer

WANG Chunmei; ZHANG Ji; LI Bei; SUN Yuyun; ZHANG Yingjian

doi:10.19732/j.cnki.2096-6210.2019.04.009

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The effect of different injection locations of ^99mTc-sulfur colloid for sentinel lymph node detection in breast cancer

更新时间：2025-12-15

- The effect of different injection locations of ^99mTc-sulfur colloid for sentinel lymph node detection in breast cancer
- Vol. 28, Issue 4, Pages: 254-259(2019)
- 作者机构：
  
  1. 复旦大学生物医学影像研究中心,上海,200032
  2. 上海分子影像探针工程技术研究中心,上海,200032
  3. 复旦大学附属肿瘤医院核医学科，复旦大学上海医学院肿瘤学系,上海,200032
  4. 上海市质子重离子医院核医学科,上海,201315
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2019.04.009
  CLC：
- Published Online：12 September 2019，
  
  Published：12 September 2019
- 稿件说明：
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王春梅,张骥,李蓓,等. ^99m Tc-硫胶体不同注射部位对乳腺癌前哨淋巴结显像效果的影响[J]. 肿瘤影像学, 2019, 28(4): 254-259 https://doi.

org/10.19732/j.cnki.2096-6210.2019.04.009
王春梅,张骥,李蓓,等. ^99m Tc-硫胶体不同注射部位对乳腺癌前哨淋巴结显像效果的影响[J]. 肿瘤影像学, 2019, 28(4): 254-259 https://doi. DOI： 10.19732/j.cnki.2096-6210.2019.04.009.

org/10.19732/j.cnki.2096-6210.2019.04.009 DOI：

摘要

目的：

探讨不同部位注射

99m

Tc-硫胶体（

99m

Tc-SC）对前哨淋巴结（sentinel lymph node，SLN）检出率的影响。

方法：

将治疗前的乳腺癌患者随机分为两组，分别进行乳晕周围（晕周）、肿瘤周围（瘤周）皮下注射

99m

Tc-SC 2 h后SPECT平面显像。个别患者加做SPECT/CT断层显像以鉴别是淋巴结还是前后方向的淋巴管，以平面显像结果为分析依据。检验分析两种注射部位，以及年龄、绝经状态及肿块大小等个体因素对腋窝前哨淋巴结（axillary sentinel lymph node，A-SLN）、内乳前哨淋巴结（internal mammary sentinel lymph node，IM-SLN）及总前哨淋巴结（total sentinel lymph node，T-SLN）检出率的影响。

结果：

共入组558例患者，A-SLN、IM-SLN及T-SLN检出率为78.7%、12.0%及80.6%。558例患者中173例患者进行瘤周注射，385例患者进行晕周注射，其A-SLN、IM-SLN、T-SLN检出率分别为65.3%、19.7%、69.4%和84.7%、8.6%、85.7%。年龄较小、尚未绝经的患者T-SLN和A-SLN显影率显著高于年龄高、已绝经患者的显影率，差异有统计学意义（

均＜0.001）；IM-SLN显影率不受年龄和绝经状态的影响。晕周注射后T-SLN、A-SLN显影率显著高于瘤周注射后的显影率，差异有统计学意义（

均＜0.001）；但瘤周注射后IM-SLN的显影率明显高于晕周注射后的显影率，差异有统计学意义（

＜0.001）。

结论：

年龄较小的患者，晕周注射能获得更高的A-SLN阳性检测率，但IM-SLN检出率低。

Abstract

Objective:

To explore the effect of different injection locations of

99m

Tc-sulfur colloid (

99m

Tc-SC) for sentinel lymph node de

tection in breast cancer.

Methods:

Breast cancer patients before treatment were divided into two groups randomly according to subcutaneous injection locations (areola or tumor around). All patients underwent SPECT planar scan 2 hours after

99m

Tc-SC injection. SPECT/CT scan was performed to distinguish lymph node or vessel in some patients.

test was used to analyze the influence of two injection locations and clinic individual characteristics

such as age

menopausal stage and tumor size

on the detection rates of axillary sentinel lymph node (A-SLN)

internal mammary sentinel lymph node (IM-SLN) and total sentinel lymph node (T-SLN).

Results:

The detection rates of A-SLN

IM-SLN and T-SLN were 78.7%

12.0% and 80.6%

respectively in 558 enrollment patients. Total 173 patients injected around the tumor. Among these patients

the detection rates of A-SLN

IM-SLN and T-SLN were 65.3%

19.7% and 69.4%

respectively. Areola around injection was performed in each of 385 patients

and the detectionrates of A-SLN

IM-SLN and T-SLN were 84.7%

8.6% and 85.7%

respectively. The detection rates of T-SLN (

＜0.001) and A-SLN (

＜0.001) in young (

＜0.001) and nonmenopausal (

＜0.001) patients were higher significantly than old and menopausal patients. However

age (

=0.436) and menopausal stage (

=0.354) didn't effect the detection rate of IM-SLN. The detection rates of T-SLN (

＜0.001)

A-SLN (

＜0.001) were higher significantly in patients with areola around injection than patients with tumor around injection. However

the detection rate of IM-SLN (

＜0.001) in patient with areola around injection was lower compared with patients with tumor around injection.

Conclusion:

Young patients with areola around injection had high detection rate of A-SLN

not IM-SLN.

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The effect of different injection locations of 99m Tc-sulfur colloid for sentinel lymph node detection in breast cancer

DOI：10.19732/j.cnki.2096-6210.2019.04.009

摘要

Abstract

关键词

Keywords

references

The effect of different injection locations of ^99mTc-sulfur colloid for sentinel lymph node detection in breast cancer