Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive system which biological behavior is diverse. It is believed that GIST has malignant potential regardless of its size. Risk grade of GIST is the main criterion for evaluating whether or not targeted therapy is carried out before and after operation. Therefore
definite pathological diagnosis and risk grade before treatment have important clinical value for the treatment of patients with GIST. This paper reviewed the advances in imaging studies on risk grade of GIST.