Correlation between dynamic contrast-enhanced magnetic resonance imaging features and molecular prognostic markers in breast cancer

SHI Qin; FU Zhiming; ZHANG Wen; LU Xiaojuan; WANG Xiaoye; BEI Jinling

doi:10.19732/j.cnki.2096-6210.2019.06.004

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Correlation between dynamic contrast-enhanced magnetic resonance imaging features and molecular prognostic markers in breast cancer

更新时间：2025-12-15

- Correlation between dynamic contrast-enhanced magnetic resonance imaging features and molecular prognostic markers in breast cancer
- Vol. 28, Issue 6, Pages: 371-376(2019)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2019.06.004
  CLC：
- Published Online：28 December 2019，
  
  Published：28 December 2019
- 稿件说明：
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石琴,付志明,张文,等. 乳腺癌动态增强磁共振成像特征与分子预后标志物的关系[J]. 肿瘤影像学, 2019, 28(6): 371-376 https://doi.

org/10.19732/j.cnki.2096-6210.2019.06.004
石琴,付志明,张文,等. 乳腺癌动态增强磁共振成像特征与分子预后标志物的关系[J]. 肿瘤影像学, 2019, 28(6): 371-376 https://doi. DOI： 10.19732/j.cnki.2096-6210.2019.06.004.

org/10.19732/j.cnki.2096-6210.2019.06.004 DOI：

摘要

目的：

探讨乳腺癌动态增强磁共振成像（dynamic contrast-enhanced magnetic resonance imaging，DCE-MRI）特征与分子预后标志物的关系。

方法：

回顾性分析68例乳腺癌患者术前DCE-MRI图像特征，比较不同分子预后标志物表达情况的DCE-MRI图像特征差异。

结果：

与雌激素受体（estrogen receptor，ER）阳性者比较，ER阴性者大肿块病灶（直径2 cm）、病灶边缘光整的比例明显升高（

=4.55，8.27；

＜0.05）；与孕激素受体（progesterone receptor，PR）阳性者比较，PR阴性者病灶边缘光整的比例明显升高（

=7.23；

＜0.05）；与人类表皮生长因子受体-2（human epidermal growth factor receptor-2，HER2）阳性者比较，HER2阴性者大肿块病灶的比例明显降低（

=4.57；

＜0.05）；与Ki-67阳性者比较，Ki-67阴性者大肿块病灶、病灶边缘光整的比例明显降低（

=4.72，7.88；

＜0.05）。乳腺癌患者MRI达峰时间为（203.1515.46）s，早期强化率为（125.1718.24）%。达峰时间与ER、PR阳性表达呈正相关（

=0.388，0.359；

＜0.05），与HER2表达、Ki-67标记指数均无显著相关性（

=-0.281，-0.310；

＞0.05）。

结论：

乳腺癌DCE-MRI图像特征，尤其是肿瘤大小、边缘状态及早期强化率，与PR、ER、HER2表达及Ki-67标记指数具有良好相关性，可为乳腺癌患者术前预测、治疗方案的制定及预后评估提供参考依据。

Abstract

Objective:

To investigate the correlation between dynamic contrast-enhanced magnetic resonance

imaging (DCE-MRI) features and molecular prognostic markers in breast cancer.

Methods:

The preoperative DCE-MRI image features of 68 patients with breast cancer were analyzed retrospectively

and the difference in DCE-MRI image features among different molecular prognostic markers were compared.

Results:

Compared with estrogen receptor (ER) positive

the proportion of large lesions (2 cm) and smooth edge of lesions were significantly increased in negative ER (

=4.55

8.27;

＜0.05). Compared with progesterone receptor (PR) positive

the proportion of smooth edge of lesions in PR negative patients was significantly increased (

=7.23;

＜0.05). Compared with human epidermal growth factor receptor-2 (HER2) positive

the proportion of large lesions in those with negative HER2 was significantly reduced (

=4.57;

＜0.05). Compared with Ki-67 positive

negative Ki-67 patients had significantly lower proportion of large lesion and smooth edge of lesions (

=4.72

7.88;

＜0.05). The peak time of MRI in breast cancer patients was (203.1515.46) s

and the rate of early enhancement was (125.1718.24) %. The peaking time was positively correlated with the positive expression of ER and PR (

=0.388

0.359;

＜0.05)

but was not significantly correlated with HER2 expression and Ki-67 labeling index (

=-0.281

-0.310;

＞0.05).

Conclusion:

DCE-MRI image features of breast cancer

especially tumor size

marginal state and rate of early enhancement

are well correlated with the expressions of PR

HER2 and Ki-67 labelingindex

which can provide reference for preoperative prediction

treatment plan formulation and prognosis evaluation of breast cancer.

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