Analysis of ultrasonographic and pathological characteristics of pure ductal carcinoma <em>in situ</em>

NIE Chenlei; SU Tong; YI Chunbei; DENG Jing; WANG Hui; GONG Haiyan; LI Cuiying

doi:10.19732/j.cnki.2096-6210.2020.02.011

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Analysis of ultrasonographic and pathological characteristics of pure ductal carcinoma in situ

更新时间：2025-12-15

- Analysis of ultrasonographic and pathological characteristics of pure ductal carcinoma in situ
- Vol. 29, Issue 2, Pages: 134-140(2020)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2020.02.011
  CLC：
- Published Online：28 April 2020，
  
  Published：28 April 2020
- 稿件说明：
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聂晨蕾,苏彤,易春蓓,等. 单纯性乳腺导管内癌的超声声像图特征及病理学特征分析研究[J]. 肿瘤影像学, 2020, 29(2): 134-140 https://doi.

org/10.19732/j.cnki.2096-6210.2020.02.011
聂晨蕾,苏彤,易春蓓,等. 单纯性乳腺导管内癌的超声声像图特征及病理学特征分析研究[J]. 肿瘤影像学, 2020, 29(2): 134-140 https://doi. DOI： 10.19732/j.cnki.2096-6210.2020.02.011.

org/10.19732/j.cnki.2096-6210.2020.02.011 DOI：

摘要

目的：

探讨单纯性乳腺导管内原位癌（ductal carcinoma in situ，DCIS）的超声声像图特征及病理学特征。

方法：

回顾并分析2016年10月2019年4月南京医科大学第一附属医院经手术后病理学检查证实为单纯性DCIS的144例患者的超声表现及病理学特征。根据超声声像图特征将其分为肿块型（Ⅰ）、腺体紊乱型（Ⅱ）、单纯导管扩张型（Ⅲ）、导管扩张伴低回声型（Ⅳ）、单纯钙化型（Ⅴ）、超声无表现型（Ⅵ）。

结果：

Ⅰ型95例（66.0%），Ⅱ型21例（14.6%），Ⅲ型7例（4.9%），Ⅳ型7例（4.9%），Ⅴ型12例（8.3%），Ⅵ型2例（1.4%），超声诊断准确率分别为83.2%（79/95）、76.2%（16/21）、0.0%（0/7）、42.9%（3/7）、83.3%（10/12）、0.0%（0/2）。超声图像上表现出钙化的患者占75例（52.1%），超声诊断准确率为86.7%（65/75），高于无钙化组且差异有统计学意义（

=11.362，

=0.001）；血流分级为Ⅱ级、Ⅲ级的患者占99例（68.8%），超声诊断准确率为86.9%（86/99），高于血流分级为0级、Ⅰ级的DCIS且差异有统计学意义（

=23.801，

=0.000）。病理学特征上，低、中级别占71例（49.3%），高级别占73例（50.7%）；分子分型中0Luminal A型占50例（34.7%），Luminal B型占63例（43.8%），人表皮生长因子受体2（human epidermal growth factor receptor 2，HER2）阳性占29例（20.1%），三阴性型占2例（1.4%）。钙化组与无钙化组病灶的病理组织学分级、分子分型差异均有统计学意义。

结论：

肿块型是DCIS最常见的超声表现，超声对DCIS的诊断准确率与其超声声像图特征有关，有无钙化以及血流的丰富程度是DCIS的诊断要点，DCIS的病理学特征与有无钙化密切相关。超声对临床诊断DCIS有重要指导作用。

Abstract

Objective:

To investigate the ultrasonographic and pathological features

of pure ductal carcinoma

in situ

（DCIS）.

Methods:

The ultrasonographic features and pathological features of 144 patients with DCIS confirmed by surgery and pathology in the First Affiliated Hospital of Nanjing Medical University from Oct. 2016 to Apr. 2019 were retrospectively analyzed. According to the characteristics of ultrasound images

it can be divided into six categories: Type Ⅰ simple mass

Type Ⅱ glandular disorder

Type Ⅲ ductal dilatation

Type Ⅳ ductal dilatation with hypoechoic mass

Type Ⅴ simple calcification

Type Ⅵ no positive finding by ultrasound.

Results:

Type Ⅰ 95 cases (66.0%)

Type Ⅱ 21 cases (14.6%)

Type Ⅲ 7 cases (4.9%)

Type Ⅳ 7 cases (4.9%)

Type Ⅴ 12 cases (8.3%)

Type Ⅵ 2 cases (1.4%). The diagnosis was 83.2% (79/95)

76.2% (16/21)

0.0% (0/7)

42.9% (3/7)

83.3% (10/12)

0.0% (0/2). Seventy-five cases (52.1%) showed calcification on ultrasound images. The diagnosis accuracy was 86.7% (65/75)

which was higher than non-calcification group (

=11.362，

=0.001). Ninety-nine cases（68.8%）showed blood flow classification Ⅱ and Ⅲ on ultrasound images. The diagnosis accuracy was 86.9% (86/99)

which was higher than low blood flow classification group (

=23.801，

=0.000). Pathological features showed that 71 cases (49.3%) were of low and middle grade

73 cases (50.7%) were ofhigh grade

50 cases (34.7%) were of Luminal A type

63 cases (43.8%) were of Luminal B type

29 cases (20.1%) were of human epidermal growthfactor receptor 2 (HER2) type

and 2 cases (1.4%) were of tri-negative type.

Conclusion:

Mass type is the most common ultrasonographic manifestation of DCIS. The diagnostic accuracy of DCIS by ultrasound is related to its ultrasonographic features. Calcification and the richness of blood flow are important factor on ultrasound images. The pathological features of DCIS are closely related to calcification. Ultrasound plays an important role in clinical

diagnosis of DCIS.

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Shanghai Institute of Medical Imaging

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Analysis of ultrasonographic and pathological characteristics of pure ductal carcinoma in situ

DOI：10.19732/j.cnki.2096-6210.2020.02.011

摘要

Abstract

关键词

Keywords

references