3.0T WBDWIBS with histogram parameters in prediction therapy response of bone metastatic breast cancer： the initial experience

GENG Xiaochuan; ZHUANG Zhiguo; ZHANG Kebei; CHEN Jie; CHENG Fang; ZHANG Qing; HUA Jia

doi:10.19732/j.cnki.2096-6210.2020.03.003

您当前的位置：

首页 >

文章列表页 >

3.0T WBDWIBS with histogram parameters in prediction therapy response of bone metastatic breast cancer： the initial experience

更新时间：2025-12-15

- 3.0T WBDWIBS with histogram parameters in prediction therapy response of bone metastatic breast cancer： the initial experience
- Vol. 29, Issue 3, Pages: 214-220(2020)
- 作者机构：
  
  1. 上海交通大学医学院附属仁济医院放射科,上海,200127
  2. 上海交通大学医学院附属仁济医院南院放射科,上海,201112
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2020.03.003
  CLC：
- Published Online：28 June 2020，
  
  Published：28 June 2020
- 稿件说明：
移动端阅览
耿小川,庄治国,张科蓓,等. 基于3.0T WBDWIBS的直方图参数评估乳腺癌骨转移疗效的诊断价值初探[J]. 肿瘤影像学, 2020, 29(3): 214-220 https://doi.

org/10.19732/j.cnki.2096-6210.2020.03.003
耿小川,庄治国,张科蓓,等. 基于3.0T WBDWIBS的直方图参数评估乳腺癌骨转移疗效的诊断价值初探[J]. 肿瘤影像学, 2020, 29(3): 214-220 https://doi. DOI： 10.19732/j.cnki.2096-6210.2020.03.003.

org/10.19732/j.cnki.2096-6210.2020.03.003 DOI：

摘要

目的：

初步探索3.0T背景抑制全身扩散加权成像（whole-body diffusion-weighted imaging with background body suppression，WBDWIBS）的表观扩散系数（apparent diffusion coefficient，ADC）值直方图参数对于预测乳腺癌骨转移疗效的诊断价值。

方法：

25例乳腺癌骨转移患者均在治疗前后完善2次WBDWIBS检查，患者疗效评估为疾病进展9例，无疾病进展16例。记录乳腺癌骨转移病灶治疗前后的直方图参数，包括平均值、标准差、偏度、峰度、最小值、10%、25%、中位数、75%、90%、最大值，并计算各个参数的变化率。治疗前后乳腺癌骨转移的ADC值直方图参数比较采用配对样本t检验或Wilcoxon秩和检验。疾病进展与无疾病进展间比较采用两独立样本t检验或Wilcoxon秩和检验。通过受试者工作特征（receiver operating characteristic，ROC）曲线评估直方图参数预测骨转移疗效的诊断效能。

结果：

25例患者从整体角度分析，治疗后乳腺癌骨转移病灶ADC值的直方图参数中除10%、标准差外均较治疗前有显著变化（

0.004）。按照疾病进展和无疾病进展分析，治疗前两组间ADC值的直方图参数值差异无统计学意义（

0.193），治疗后ADC值的标准差、10%、25%的值及其变化率两组间差异均有统计学意义（

0.024），且具有合理的准确性。

结论：

基于3.0T的WBDWIBS的ADC值直方图参数对于预测乳腺癌骨转移的疗效具有可行性。

Abstract

Objective:

To determine the diagnostic performance of apparent diffusion coefficient (ADC) histogram parameters of 3.0T whole-body diffusion-weighted imaging with background body suppression (WBDWIBS) for predicting response of breast cancer bone metastasis.

Methods:

For this prospective study

25 study participants with breast cancer bone metastasis underwent WBDWIBS before and after therapy. There were 9 patients with progressive disease. The histogram parameters of breast cancer bone metastases before and after treatment were recorded

including mean

standard deviation

skewness

kurtosis

minimum

10%

25%

median

75%

90%

maximum

and the corresponding rate of change. ADC histogram parameters before and after treatment were compared using paired sample t test or Wilcoxon rank-sum test. Two independent sample t-tests or Wilcoxon rank-sum tests were compared between progressive disease and non-progressive disease. Receiver operating characteristic (ROC) curve was used to determine the performance of ADC histogram parameters for response prediction.

Results:

On the overall aspect

after therapy

all the histogram parameters except for 10%

standard deviation values were significantly different from those prior to therapy (

0.004). On the therapy response aspect

there was no statistical difference between the two groups prior to therapy (

0.193). The standard deviation

10%

25% values and corresponding rate of change were statistical different between the two groups (

0.024) with reasonable accuracy.

Conclusion:

The 3.0T WBDWIBS with histogram analysis is favorable for predicting therapy response of breast cancer bone metastasis.

关键词

Keywords

references

Views

1649

下载量

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Magnetic resonance imaging with apparent diffusion coef f icient histogram analysis: evaluation of luminal type breast cancer prior to neoadjuvant chemotherapy

Prediction of sentinel lymph node metastasis in breast cancer using multiparametric MRI radiomics and machine learning models

Study on the predictive value of multi-parameter spectral CT changes for prognosis in patients with breast cancer bone metastasis

The progress of breast MRI in evaluating breast conservation therapy and ipsilateral breast tumor recurrence

Clinical significance of ultrasonic myocardial work index in evaluating cancer therapy-related cardiac dysfunction after breast cancer chemotherapy

Related Author

GENG Xiaochuan

HUA Jia

ZHUANG Zhiguo

CHEN Jie

ZHANG Kebei

ZHANG Qing

CHENG Fang

Hongkai YANG

Related Institution

Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University

Department of Radiology, Ma’anshan People’s Hospital, Ma’anshan

The Graduate School, Anhui Medical University

The Fifth Clinical Medical College of Anhui Medical University

Department of Radiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University

AI问答

⁰