Value of&nbsp; <sup>18 </sup>F-FDG PET/CT metabolic parameters in predicting lymph node metastasis in non-small cell lung cancer

ZHENG Qingzhong; SU Jiemin; LI Xiaoling; CHEN Zhuangjun; WANG Shengzhi

doi:10.19732/j.cnki.2096-6210.2020.03.013

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Value of ¹⁸F-FDG PET/CT metabolic parameters in predicting lymph node metastasis in non-small cell lung cancer

更新时间：2025-12-15

- Value of ¹⁸F-FDG PET/CT metabolic parameters in predicting lymph node metastasis in non-small cell lung cancer
- Vol. 29, Issue 3, Pages: 283-287(2020)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2020.03.013
  CLC：
- Published Online：28 June 2020，
  
  Published：28 June 2020
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郑庆中,苏洁敏,李小玲,等. ¹⁸F-FDG PET/CT代谢参数预测非小细胞肺癌淋巴结转移的价值[J]. 肿瘤影像学, 2020, 29(3): 283-287 https://doi.

org/10.19732/j.cnki.2096-6210.2020.03.013
郑庆中,苏洁敏,李小玲,等. ¹⁸F-FDG PET/CT代谢参数预测非小细胞肺癌淋巴结转移的价值[J]. 肿瘤影像学, 2020, 29(3): 283-287 https://doi. DOI： 10.19732/j.cnki.2096-6210.2020.03.013.

org/10.19732/j.cnki.2096-6210.2020.03.013 DOI：

摘要

目的：

探讨

F-FDG PET/CT代谢参数预测非小细胞肺癌（non-small cell lung cancer，NSCLC）淋巴结转移的价值。

方法：

回顾并分析治疗前接受

F-FDG PET/CT检查并经病理学检查确诊的125例NSCLC患者的临床资料，根据其是否发生淋巴结转移分为淋巴结转移组（

=38）和无淋巴结转移组（

＝87）。分析最大标准摄取值（maximum standardized uptake value，SUV

max

）、肿瘤代谢体积（metabolic tumor volume，MTV）和病灶糖酵解总量（total lesion glycolysis，TLG）与临床因素的关系。绘制受试者工作特征（receiver operating characteristic，ROC）曲线，分析SUV

max

、MTV及TLG预测NSCLC淋巴结转移的价值。结果：淋巴结转移组SUV

max

（16.28

10.05）、MTV（32.74 cm

22.37 cm

）及TLG（241.50

215.30）均明显高于无淋巴结转移组（

＜0.01）。淋巴结转移患者SUV

max

、MTV及TLG与TNM分期及病灶最大直径相关（

＜0.05）。ROC曲线分析显示，SUV

max

、MTV及TLG预测NSCLC淋巴结转移的最佳截断值分别为13.40、27.24 cm 3 及230.53，MTV预测NSCLC淋巴结转移的AUC（0.874，95% CI：0.808～0.937）明显高于SUV

max

（0.776，95% CI：0.719～0.832）及TLG（0.738，95% CI：0.685～0.802），其灵敏度和特异度为89.3%和84.2%。

结论：

F-FDG PET/CT代谢参数对预测NSCLC淋巴结转移具有一定价值，其中MTV的预测价值较高。

Abstract

Objective:

To investigation the value of

F-FDG PET/CT metabolic parameters in predicting lymph node metastasis of non-small cell lung cancer (NSCLC).

Methods:

The clinical data of 125 NSCLC patients who underwent

F-FDG PET/CT examination and confirmed by pathology before treatment were retrospectively analyzed. The patients were divided into lymph node metastasis group (

=38) and non-lymph node metastasis group (

=87). The relationship between clinical factors and maximum standardized uptake (SUV

max

)

metabolic tumor volume (MTV) and total lesion glycolysis (TLG) was analyzed. The receiver operating characteristic (ROC) curve was used to analyze the value of SUV

max

MTV and TLG in predicting lymph node metastasis in NSCLC.

Results:

SUV

max

(16.28

10.05)

MTV (32.74 cm

22.37 cm

) and TLG (241.50

215.30) in lymph node metastasis group were significantly higher than those in non-lymph node metastasis group (

＜0.01). SUV

max

MTV and TLG in patients with lymph node metastasis were correlated with TNM stage and maximum diameter of the lesion (

＜0.05). ROC curve analysis showed that the best cut-off values of SUV

max

MTV and TLG for predicting NSCLC lymph node metastasis were 13.40

27.24 cm

and 230.53

respectively. The AUC of MTV (0.874

95% CI: 0.808-0.937) predicting NSCLC lymph node metastasis were significantly higher than SUV

max

(0.776

95% CI: 0.719-0.832) and TLG (0.738

95% CI: 0.685-0.802)

with sensitivity and specificity of 89.3% and 84.2%.

Conclusion:

F-FDG PET/CT metabolic parameters have a certain value in predicting lymph node metastasis of NSCLC

and MTV has a higher predictive value.

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Related Institution

Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences

Department of Automation, Shanghai Jiao Tong University

Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University

Department of Journal Center, The Third Affiliated Hospital of Sun Yat-Sen University

School of Public, Sun Yat-Sen University

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Value of 18 F-FDG PET/CT metabolic parameters in predicting lymph node metastasis in non-small cell lung cancer

DOI：10.19732/j.cnki.2096-6210.2020.03.013

摘要

Abstract

关键词

Keywords

references

Value of ¹⁸F-FDG PET/CT metabolic parameters in predicting lymph node metastasis in non-small cell lung cancer