Quantitative T1 mapping in liver: comparison of Look-locker and B1-corrected VFA

HAN Shuai; MENG Fan; QU Jinrong

doi:10.19732/j.cnki.2096-6210.2020.05.011

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Quantitative T1 mapping in liver: comparison of Look-locker and B1-corrected VFA

更新时间：2025-12-15

- Quantitative T1 mapping in liver: comparison of Look-locker and B1-corrected VFA
- Vol. 29, Issue 5, Pages: 489-494(2020)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2020.05.011
  CLC：
- Published Online：28 October 2020，
  
  Published：28 October 2020
- 稿件说明：
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韩帅,孟帆,曲金荣. 对比Look-locker和B1-corrected VFA在肝脏T1值定量分析中的初步应用[J]. 肿瘤影像学, 2020, 29(5): 489-494 https://doi.

org/10.19732/j.cnki.2096-6210.2020.05.011
韩帅,孟帆,曲金荣. 对比Look-locker和B1-corrected VFA在肝脏T1值定量分析中的初步应用[J]. 肿瘤影像学, 2020, 29(5): 489-494 https://doi. DOI： 10.19732/j.cnki.2096-6210.2020.05.011.

org/10.19732/j.cnki.2096-6210.2020.05.011 DOI：

摘要

目的：

评估两种平扫T1 mapping的成像方法（自由呼吸Look-locker序列和屏气B1-corrected VFA序列）所得肝左叶及右叶T1值的定量特征，并评价其变异度。

方法：

收集于郑州大学附属肿瘤医院就诊的肝脏疾病患者70例（同时行自由呼吸Look-locker序列和屏气B1-corrected VFA序列扫描），排除不能配合屏气患者4例，最终66例患者纳入研究。分别测量66例患者Look-locker序列和屏气B1-corrected VFA序列在肝脏左叶及右叶的T1值，并比较两种成像方法所得T1值的差异，应用变异系数（coefficient of variation，CV）来评价两种成像方法的变异度，采用Bland-Altman法对医师1及医师2之间的测量结果进行对比。

结果：

2名阅片者之间采用Look-locker序列及B1-corrected VFA序列所得T1值（肝左、右叶）的相关系数分别为0.961及0.962、0.884及0.828（

均＜0.001）。两种序列在肝硬化背景下及非肝硬化背景下所得T1值之间差异无统计学意义（

＞0.05）；比较Look-locker序列在肝脏左、右叶所得T1值［（803.3980.59）10

-3

s、（777.5384.97）10

-3

s］及B1-corrected VFA序列所得T1值［（869.77116.67）10

-3

s、（852.08125.03）10

-3

s］，差异均无统计学意义（

＞0.05，

=1.794、0.840）。两种序列在肝脏左、右叶所得T1值之间差异有统计学意义（

＜0.05，

=14.63、15.48）。Look-locker序列在肝左叶及肝右叶所得T1值的变异系数（分别为0.100、0.109）低于B1-corrected VFA序列（分别为0.134、0.147）。Bland-Altman散点图显示Look-locker序列测定的 f 值分布相对更集中。

结论：

对肝脏正常组织采用Look-locker序列和B1-corrected VFA序列所得到的T1值是不同的，T1值的变化不能提示肝硬化，采用Look-locker序列测量的T1值一致性评估变异度小，图像质量更稳定，临床实用价值更高。

Abstract

Objective:

To evaluate the quantitative characteristics of T1 values of left and right lobes obtained by two kinds of T1 mapping methods (free-breathing Look-locker sequence and breath-holding B1-corrected VFA sequence)

and to evaluate their variability.

Methods:

Seventy patients with liver disease were enrolled in Affiliated Cancer Hospital of Zhengzhou University Henan Cancer Hospital (both free-breathing Look-locker sequences and breath-holding B1-corrected VFA sequence scans). Four patients were excluded because of the inability to cooperate with the breath. The final 66 patients were included in the study. The T1 values of the Look-locker sequence and breath-hold B1-corrected VFA sequence in the left and right lobes of the liver were measured in 66 patients

and the differences in T1 values obtained from the two imaging methods were compared. The coefficient of variation (CV) of T1 values was compared to evaluate the reliability of these two sequences. Bland-Altman method was used to compare the measurement results between physician 1 and physician 2.

Results:

The correlation coefficients of the T1 value in left lobe was 0.961 in Look-locker and 0.884 in B1-corrected VFA respectively

and it in right lobe was 0.962 and 0.828

respectively (

0.001). It is no significant difference between cirrhosis and non-cirrhosis in Look-locker and B1-corrected VFA of left and right lobe of liver (

0.05). Compared the T1 values ［(803.3980.59)10

-3

(777.5384.97)10

-3

s］ obtained from the Look-locker sequencein the left and right lobes of the liver with the T1 values obtained from the B1-corrected VFA sequence ［(869.77116.67) 10

-3

(852.08125.03)10

-3

s］. The difference was not statistically significant (

0.05;

=1.794

0.840). There was a statistically significant difference between the two sequences in the T1 values obtained from the left and r

ight lobes of the liver (

0.05

=14.63

15.48). The coefficient of variation of the left and right lobe of liver in Look-locker (0.100

0.109) was significantly lower than in B1-corrected VFA T1 mapping (0.134

0.147). The Bland-Altman scatter plot shows that the distribution of f values determined by the Look-locker sequence is relatively more concentrated.

Conclusion:

The T1 values obtained by using the Look-locker sequence and the B1-corrected VFA sequence for normal liver tissues are different. The change in the T1 value does not indicate liver cirrhosis. The consistency of the T1 value measured by the Look-locker sequence is assessed to be small. The image quality is more stable

and the clinical practical value is higher..

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