Analysis of correlation between clinicopathologic and ultrasonographic features of triple-negative breast cancer and axillary lymph node metastasis

LIU Xinpei; ZHA Hailing; GONG Haiyan; DING Zhiying; WANG Hui; LI Cuiying

doi:10.19732/j.cnki.2096-6210.2021.02.005

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Analysis of correlation between clinicopathologic and ultrasonographic features of triple-negative breast cancer and axillary lymph node metastasis

更新时间：2025-12-15

- Analysis of correlation between clinicopathologic and ultrasonographic features of triple-negative breast cancer and axillary lymph node metastasis
- Vol. 30, Issue 2, Pages: 86-91(2021)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2021.02.005
  CLC：
- Published Online：28 April 2021，
  
  Published：28 April 2021
- 稿件说明：
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刘心培,查海玲,巩海燕,等. 三阴性乳腺癌临床及超声图像特征与腋窝淋巴结转移的相关性分析[J]. 肿瘤影像学, 2021, 30(2): 86-91 https://doi.

org/10.19732/j.cnki.2096-6210.2021.02.005
刘心培,查海玲,巩海燕,等. 三阴性乳腺癌临床及超声图像特征与腋窝淋巴结转移的相关性分析[J]. 肿瘤影像学, 2021, 30(2): 86-91 https://doi. DOI： 10.19732/j.cnki.2096-6210.2021.02.005.

org/10.19732/j.cnki.2096-6210.2021.02.005 DOI：

摘要

目的：

探讨三阴性乳腺癌（triple-negative breast cancer，TNBC）患者腋窝淋巴结转移与肿瘤临床病理学特征及超声图像特征之间的关系。

方法：

选取2016年1月2019年9月在南京医科大学第一附属医院经术后病理学检查证实为TNBC的162例女性患者，其中58例为淋巴结转移组，104例为非转移组，应用单因素及logistic回归分析两组的临床病理学参数（包括年龄、Ki-67增殖指数、组织学分级）、超声图像特征与腋窝淋巴结转移的相关性。

结果：

单因素分析显示，两组患者年龄（45岁）、组织学分级（Ⅲ级），以及超声图像中肿块大小（＞20 mm）、边缘、血流分级（Ⅱ~Ⅲ级）差异有统计学意义，与腋窝淋巴结转移具有相关性（

＜0.05）；logistic回归分析显示，患者年龄（OR=0.452，

=0.048）、组织学分级（OR=0.346，

=0.012），超声图像的肿块大小（OR=2.273，

=0.023）以及肿块边缘（OR=0.410，

=0.038）是TNBC腋窝淋巴结转移的独立危险因素。

结论：

超声图像特点结合临床病理学特征可以预测TNBC腋窝淋巴结的转移情况，指导临床更好地选择腋窝淋巴结的手术方案。

Abstract

Objective:

To investigate the relationship between axillary lymph node metastasis and tumor features (clinicopathologic and ultrasonographic features) in patients with triple-negative breast cancer (TNBC).

Methods:

In this study

162 female patients were selected

with TNBC confirmed by pathology in the First Affiliated Hospital of Nanjing Medical University from Janua

ry 2016 to September 2019

including lymph node metastasis group with 58 patients and non-metastasis group with 104 patients. The association of clinicopathological (including age

Ki-67 proliferation index

histological grade) and ultrasonographic features of TNBC with axillary lymph node metastasis was determined by univariate and logistics regression analyses.

Results:

Univariate analysis showed that the parameters of age (45 years)

histological grade (Ⅲ grade)

tumor size (＞20 mm)

edge and blood flow grade (Ⅱ-Ⅲ grade) were significantly different between the two groups

which were correlated with axillary lymph node metastasis (P＜0.05). Logistic regression analysis showed that age (OR=0.452

P=0.048)

histological grade (OR=0.346

P=0.012)

tumor size (OR=2.273

P=0.023) and tumor edge (OR=0.410

P=0.038) were independent risk factors for axillary lymph node metastasis in TNBC.

Conclusion:

Ultrasonographic features combined with clinicopathologic features can predict the metastasis of axillary lymph nodes in TNBC and guide the clinical selection of axillary lymph node surgery.

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Department of Radiology, The First Affiliated Hospital of Soochow University

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Department of Breast Surgery, Nanjing Medical University First Hospital

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