Objective:

Based on dynamic enhanced magnetic resonance imaging (MRI)

to explore the consistency of radiomics parameters obtained by different observers manually delineating region of interest (ROI).

Methods:

A total of 62 patients with breast cancer diagnosed in Fudan University Shanghai Cancer Center were selected. The ITK-SNAP software was used to the three- dimensional lesion delineation. The morphological characteristic and first-order parameters in the ROI

were extracted

and then the consistency test was carried out.

Results:

In the overall tumors

there were a higher inter-observer and intra-observer agreement (＞0.75)

and the intra-observer agreement (all ＞0.9) was higher than inter-observers (all ＞0.8). When we divided tumors into mass-like and nonmass-like enhancement according to the tumor enhancement morphology

we found that the consistency of the morphological parameters was well (all ＞0.75)

but the consistency of peak and minimum values of the first-order parameter were less than 0.75. Among tumors of different T stages

the consistency of the first-order parameter peak and skewness of T

1

+T

2

tumors are less than 0.75

and the value of T

1

+T

2

tumors was generally lower than that of T

3

tumors.

Conclusion:

The consistency of the radiomics parameters between different observers is relatively high

which is a further confirmation of the reliability of the results of previous related studies. The consistency is still not appreciable among tumors with different T stages and different enhancement forms among some first-order parameters. Therefore

the sample size should be expanded for further stratified analysis.