Correlation between <em>BRAF</em> V600E mutation and invasiveness and ultrasound characteristics of papillary carcinoma of thyroid

ZHAO Meili; ZHANG Wenting; CHANG Jun; CHEN Songwang; SHAO Guoqiang

doi:10.19732/j.cnki.2096-6210.2021.05.009

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Correlation between BRAF V600E mutation and invasiveness and ultrasound characteristics of papillary carcinoma of thyroid

更新时间：2025-12-15

- Correlation between BRAF V600E mutation and invasiveness and ultrasound characteristics of papillary carcinoma of thyroid
- Vol. 30, Issue 5, Pages: 376-381(2021)
- 作者机构：
  
  1. 南京医科大学附属南京医院（南京市第一医院）功能检查科,江苏,南京,210006
  2. 南京医科大学附属南京医院（南京市第一医院）核医学科,江苏,南京,210006
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2021.05.009
  CLC：
- Published Online：28 October 2021，
  
  Published：28 October 2021
- 稿件说明：
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赵美丽,张文婷,常隽,等. BRAF V600E突变与甲状腺乳头状癌侵袭性及超声特征的相关性研究[J]. 肿瘤影像学, 2021, 30(5): 376-381 https://doi.

org/10.19732/j.cnki.2096-6210.2021.05.009
赵美丽,张文婷,常隽,等. BRAF V600E突变与甲状腺乳头状癌侵袭性及超声特征的相关性研究[J]. 肿瘤影像学, 2021, 30(5): 376-381 https://doi. DOI： 10.19732/j.cnki.2096-6210.2021.05.009.

org/10.19732/j.cnki.2096-6210.2021.05.009 DOI：

摘要

目的：

探讨

BRAF

V600E突变判断甲状腺乳头状癌（papillary carcinoma of thyroid，PTC）侵袭性的价值及与超声特征的相关性。

方法：

选取经术后病理学检查证实，术前行超声引导下细针抽吸细胞学检查（fine-needle aspiration cytology，FNAC）及

BRAF

V600E检测PTC患者174例，分为突变组（151例）与无突变组（23例），比较各临床病理学及超声特征的组间差异，单因素分析与

BRAF

V600E突变的相关性，二元logistic回归分析筛选出与

BRAF

V600E突变密切相关危险因素。

结果：

组间比较

BRAF

V600E突变与各临床病理学特征差异均无统计学意义（

＞0.05）；与部分超声特征（结节位置、最大径、钙化、后方衰减）差异有统计学意义（

＜0.05）；甲状腺癌结节钙化及位置是与

BRAF

V600E突变密切相关的独立危险因素（

＜0.05），无钙化或贴近前包膜PTC结节更易发生

BRAF

V600E突变。

结论：

BRAF

V600E突变与PTC侵袭性特征无明显相关性，与钙化及位置密切相关。当可疑PTC结节无钙化或贴近前包膜时发生

BRAF

V600E突变概率大。

Abstract

Objective:

To evaluate the value of

BRAF

V600E mutation in determining the invasiveness of papillary carcinoma of thyroid (PTC) and its related influencing factors.

Methods:

A total of 174 PTC patients who underwent ultrasound guided fine- needle aspiration cytology (FNAC) and

BRAF

V600E mu

tation detection before surgery were selected. All PTC patients were divided into mutation group 151 cases and no mutation group of 23 cases. The clinical pathological features and the ultrasonic characteristics between the two groups were compared

and single factor analyzed the correlation between observational indexes and

BRAF

V600E mutation

binary logistic regression analysis screened out risk factors closely related to

BRAF

V600E mutation.

Results:

There was no statistical difference in

BRAF

V600E mutation and clinicopathological features between the two groups (

＞0.05)

and there was a statistical difference in some ultrasonic features (nodule position

maximum diameter

calcification

and posterior attenuation) between them (

＜0.05). Only the calcification and location of cancer nodules were closely related to

BRAF

V600E (

＜0.05).

BRAF

V600E mutations were more likely to occur in the PTC nodules which were close to the anterior capsule and without calcification.

Conclusion:

BRAF

V600E mutation has no obvious correlation with PTC invasive characteristics

and it is closely related to calcification and location in ultrasonic features. When the suspected PTC nodule has no calcification or is close to the anterior capsule

BRAF

V600E mutation is likely more freguent.

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Correlation between BRAF V600E mutation and invasiveness and ultrasound characteristics of papillary carcinoma of thyroid

DOI：10.19732/j.cnki.2096-6210.2021.05.009

摘要

Abstract

关键词

Keywords

references