The prognostic value of&nbsp; 18 F-FDG PET/CT in children and adolescents with anaplastic large cell lymphoma

GOU Jinyu; CHEN Suyun; WU Shuqi; YIN Yafu; WANG Hui

doi:10.19732/j.cnki.2096-6210.2021.05.016

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The prognostic value of 18 F-FDG PET/CT in children and adolescents with anaplastic large cell lymphoma

更新时间：2025-12-15

- The prognostic value of 18 F-FDG PET/CT in children and adolescents with anaplastic large cell lymphoma
- Vol. 30, Issue 5, Pages: 414-421(2021)
- 作者机构：
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- DOI：10.19732/j.cnki.2096-6210.2021.05.016
  CLC：
- Published Online：28 October 2021，
  
  Published：28 October 2021
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苟金玉,陈素芸,吴书其,等. ¹⁸ F-FDG PET/CT在儿童及青少年间变性大细胞淋巴瘤预后分析中的价值[J]. 肿瘤影像学, 2021, 30(5): 414-421 https://doi.

org/10.19732/j.cnki.2096-6210.2021.05.016
苟金玉,陈素芸,吴书其,等. ¹⁸ F-FDG PET/CT在儿童及青少年间变性大细胞淋巴瘤预后分析中的价值[J]. 肿瘤影像学, 2021, 30(5): 414-421 https://doi. DOI： 10.19732/j.cnki.2096-6210.2021.05.016.

org/10.19732/j.cnki.2096-6210.2021.05.016 DOI：

摘要

目的：

分析儿童、青少年间变性大细胞淋巴瘤（anaplastic large cell lymphoma，ALCL）的治疗前

F-FDG正电子发射体层成像（positron emission tomography，PET）/计算机体层成像（computed tomography，CT）影像学表现及其代谢参数的预后价值。

方法：

回顾并分析24例ALCL初诊患者（男性19例，女性5例，年龄3~20岁）的临床资料及

F-FDG PET/CT影像学表现及代谢参数，包括最大标准摄取值（maximum standardized uptake value，SUVmax）、平均标准摄取值（mean standardized uptake value，SUVmean）、全身肿瘤代谢体积（metabolic tumor volume，MTV）和糖酵解总量（total lesion glycolysis，TLG），分析参数与患者预后的关系。采用两样本t检验、Mann-Whitney U检验及

检验比较不同表型的ALCL患者的临床参数、

F-FDG PET/CT影像学表现及代谢参数。

结果：

中位随访期为39个月，有3例患者死亡，另有4例复发。24例ALCL患者中，15例首诊患者伴随B症状，9例首诊患者不伴随B症状。首诊伴随B症状患者的中位SUVmax为28.68（15.61~32.87），首诊不伴随B症状的患者中位SUVmax为27.15（17.71~35.40），2种表型ALCL患者的

F-FDG代谢差异无统计学意义（

＞0.05）。在单因素生存分析中白细胞的值与总生存期（overall survival，OS）在统计学上存在相关关系；MTV、骨髓SUVmax及C反应蛋白（C-reactive protein，CRP）与无进展生存期（progression-free survival，PFS）在统计学上存在相关关系；其余所有的临床基线特征、基础检验定量指标和

F-FDG PET/CT定量指标与OS/PFS均无关。并且，将临床基线特征、检验定量指标和

F-FDG PET/CT定量指标与OS/PFS一起做多变量分析时，所有参数差异均无统计学意义。

结论：

F-FDG PET/CT可以

较好地反映ALCL患者病灶分布范围及代谢活性，CRP、WBC、MTV和骨髓SUVmax对ALCL患者的疾病进展有一定的预测价值，能为临床诊疗提供依据。

Abstract

Objective:

To summarize the pre-treatment

F-FDG positron emission tomography (PET)/computed tomography (CT) findings and the prognostic value of metabolic parameters in children and adolescents with anaplastic large cell lymphoma (ALCL).

Methods:

Twenty-four newly diagnosed children with ALCL (19 males

5 females

ages 3-20 years) were included in this retrospective study. Clinic-pathological variables and

F-FDG PET/CT metabolic parameters including maximum standardized uptake value (SUVmax)

mean standardized uptake value (SUVmean)

whole-body metabolic tumor volume (MTV)

total lesion glycolysis (TLG) were reviewed. Two sample t test

Mann-Whitney U test and

test were used to compare the clinical parameters

F-FDG PET/CT metabolic parameters of children with different phenotypes of ALCL.

Results:

The median follow-up period was 39 months

3 children died and 4 recurred. Among the 24 children with ALCL

15 cases were accompanied by B symptoms in the first diagnosis

and 9 cases were not accompanied by B symptoms in the first diagnosis. The median maximum standardized uptake value (SUVmax) was 28.68（15.61-32.87）in the children with symptoms B

and 27.15（17.71-35.40）in the children without B symptoms. There was no statistically significant difference in

F-FDG metabolism between the two phenotypes of ALCL (P 0.05).The value of white blood cell (WBC) was statistically correlated with overall survival (OS). Metabolic tumor volume (MTV)

Bone marrow SUVmax and C-reactive protein (CRP) were statistically correlated with progression-free survival (PFS). Other clinical baseline features

laboratory indexes

and

F-FDG PET/CT quantitative indicators were not associated with OS/PFS in univariate analysis. In addition

when the cl

inical baseline features

laboratory indexes

and

F-FDG PET/CT quantitative indicators were combined with OS/PFS for multivariate analysis

none of the parameters were statistically significant.

Conclusion:

F-FDG PET/ CT can indicate the extent and metabolic activity of ALCL. CRP

the value of WBC

MTV and bone marrow SUVmax have certain predictive value for disease progression in children with ALCL

thus providing information for clinical practice.

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The prognostic value of 18 F-FDG PET/CT in children and adolescents with anaplastic large cell lymphoma

DOI：10.19732/j.cnki.2096-6210.2021.05.016

摘要

Abstract

关键词

Keywords

references