The predictive value of clinical ultrasonographic features and <em>BRAF </em>gene mutation in lymph node metastasis in the cervical central region of papillary thyroid microcarcinoma

GUO Man; WEN Baojie; ZHANG Jie; WU Min; KONG Wentao

doi:10.19732/j.cnki.2096-6210.2021.06.007

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The predictive value of clinical ultrasonographic features and BRAF gene mutation in lymph node metastasis in the cervical central region of papillary thyroid microcarcinoma

更新时间：2025-12-15

- The predictive value of clinical ultrasonographic features and BRAF gene mutation in lymph node metastasis in the cervical central region of papillary thyroid microcarcinoma
- Vol. 30, Issue 6, Pages: 472-477(2021)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2021.06.007
  CLC：
- Published Online：28 December 2021，
  
  Published：28 December 2021
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郭曼,闻宝杰,张捷,等. 临床超声特征及BRAF基因突变在甲状腺微小乳头状癌颈中央区淋巴结转移中的预测价值[J]. 肿瘤影像学, 2021, 30(6): 472-477 https://doi.

org/10.19732/j.cnki.2096-6210.2021.06.007
郭曼,闻宝杰,张捷,等. 临床超声特征及BRAF基因突变在甲状腺微小乳头状癌颈中央区淋巴结转移中的预测价值[J]. 肿瘤影像学, 2021, 30(6): 472-477 https://doi. DOI： 10.19732/j.cnki.2096-6210.2021.06.007.

org/10.19732/j.cnki.2096-6210.2021.06.007 DOI：

摘要

目的：

探讨临床超声特征及BRAF基因对甲状腺微小乳头状癌（papillary microcarcinoma of the thyroid，PTMC）患者颈中央区淋巴结转移（central lymph node metastasis，CLNM）的预测价值。

方法：

收集在南京大学医学院附属鼓楼医院行甲状腺切除术的509例PTMC患者，将其分为有转移组和无转移组，回顾并分析其临床资料、超声及病理学特征。采用单因素分析及多因素分析评估CLNM相关的危险因素。

结果：

509例PTMC患者中有203例（39.9%）存在CLNM。多因素分析显示年龄＜45岁（OR=2.453，

＜0.001）、肿瘤直径0.7 cm（OR=1.729，

=0.021）、微钙化（OR=1.914，

=0.002）、双侧叶（OR=1.947，

=0.005）、包膜侵犯（OR=1.804，

=0.004）是PTMC患者CLNM的独立危险因素。而

BRAF

基因突变在两组间差异无统计学意义（

=0.850）。

BRAF

V600E突变（-）与

BRAF

V600E突变（+）对比显示，两组仅在纵横比和微钙化中差异有统计学意义（

＜0.001，

=0.011）。

结论：

对于PTMC患者，年龄＜45岁、肿瘤直径0.7 cm、双侧叶、微钙化、包膜侵犯可以预测CLNM，但BRAF基因突变与CLNM不相关。

Abstract

Objective:

To investigate the value of clinical ultrasonographic features and

BRAF

gene for the prediction of central lymph node metastasis (CLNM) in patients with papillary microcarcinoma of the thyroid (P

TMC).

Methods:

A total of 509 PTMC patients who underwent thyroidectomy in Affiliated Drum Tower Hospital

Medical School of Nanjing University were included in this study. They were divided into metastatic group and non-metastatic group. Their clinical data

ultrasonic and pathological characteristics were retrospectively analyzed. Univariate and multivariate analysis were used to evaluate the risk factors associated with CLNM.

Results:

CLNM was present in 203 (39.9%) of 509 PTMC patients. Multivariate analysis showed that age ＜45 years (OR=2.453

＜0.001)

diameter of tumor0.7 cm (OR=1.729

=0.021)

micro-calcification (OR=1.914

=0.002)

bilateral lobe (OR=1.947

=0.005)

and capsule invasion (OR=1.804

=0.004) were independent risk factors for CLNM. However

there was no significant difference in

BRAF

gene mutation between the two groups (

=0.850). Comparison between

BRAF

V600E (-) and

BRAF

V600E (+) showed that the differences between the two groups were only statistically significant in aspect ratio and micro- calcification (

＜0.001

=0.011).

Conclusion:

For PTMC patients

age＜45 years

diameter of tumor0.7 cm

bilateral growth

micro-calcification and capsule invasion can predict CLNM

but

BRAF

gene mutation cannot.

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Related Author

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Related Institution

Department of Ultrasound, Shanxi Cancer Hospital, Chinese Academy of Medical Sciences Cancer Hospital Shanxi Hospital, Shanxi Medical University Affiliated Cancer Hospital

Department of Ultrasound, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University

Department of Ultrasound, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University

上海交通大学医学院附属第六人民医院超声医学科，上海 200233 2. 上海超声医学研究所

Department of Ultrasound, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine

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The predictive value of clinical ultrasonographic features and BRAF gene mutation in lymph node metastasis in the cervical central region of papillary thyroid microcarcinoma

DOI：10.19732/j.cnki.2096-6210.2021.06.007

摘要

Abstract

关键词

Keywords

references