The efficacy of ultrasound-guided percutaneous radiofrequency ablation for uremia with secondary hyperparathyroidism

CHANG Ting; HE Nianan; YE Xianjun; FANG Jing; LI Mengxue

doi:10.19732/j.cnki.2096-6210.2021.06.008

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The efficacy of ultrasound-guided percutaneous radiofrequency ablation for uremia with secondary hyperparathyroidism

更新时间：2025-12-15

- The efficacy of ultrasound-guided percutaneous radiofrequency ablation for uremia with secondary hyperparathyroidism
- Vol. 30, Issue 6, Pages: 478-482(2021)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2021.06.008
  CLC：
- Published Online：28 December 2021，
  
  Published：28 December 2021
- 稿件说明：
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常婷,何年安,叶显俊,等. 超声引导下经皮射频消融治疗继发性甲状旁腺功能亢进症的疗效评估[J]. 肿瘤影像学, 2021, 30(6): 478-482 https://doi.

org/10.19732/j.cnki.2096-6210.2021.06.008
常婷,何年安,叶显俊,等. 超声引导下经皮射频消融治疗继发性甲状旁腺功能亢进症的疗效评估[J]. 肿瘤影像学, 2021, 30(6): 478-482 https://doi. DOI： 10.19732/j.cnki.2096-6210.2021.06.008.

org/10.19732/j.cnki.2096-6210.2021.06.008 DOI：

摘要

目的：

探讨超声引导下经皮射频消融（radiofrequency ablation，RFA）治疗尿毒症继发性甲状旁腺功能亢进症（secondary hyperparathyroidism，SHPT）的短期疗效。

方法：

选取36例SHPT患者为研究对象，其中16例在超声引导下行RFA治疗，20例行甲状旁腺切除术（parathyroidectomy，PTX），对比分析两组临床资料、实验室检查（术后1 d、1周、1个月、3个月、6个月及1年的甲状旁腺激素（parathyroid hormone，PTH）、血钙、血磷及碱性磷酸酶（alkaline phosphatase，ALP）水平，观察临床症状的改善及并发症的发生情况，评估治疗的安全性和疗效。

结果：

两组患者术后1 d、1周、1个月、3个月、6个月及1年的PTH水平、血钙水平、血磷水平与术前相比均显著下降（

＜0.05），ALP水平前后无明显差异（

＞0.05），两组间对比术后实验室指标无明显差异（

＞0.05）。两组患者术后肌无力、骨痛、皮肤瘙痒及神经系统症状均得到明显改善。RFA术后出现声音嘶哑合并低钙血症1例，术后肌间血肿1例，PTX术后1例出现低钙血症，1例出现声音嘶哑，差异无统计学意义（

＞0.05）。

结论：

超声引导下RFA治疗SHPT的疗效与PTX相近，能明显改善患者临床症状，提高生活质量。

Abstract

Objective:

To investigate the treatment of secondary hyperparathyroidism (SHPT) with ultrasound-guided percutaneous radiofrequency ablation (RFA).

Methods:

A total of 36 SHPT patients were selected as the study subjects

of which 16 were treated with ultrasound guided RFA

20 underwent traditional parathyroidectomy (PTX). The clinical data

lab

oratory examination (postoperative 1 d

1 week

1 month

3 months

6 months and 1 year of parathyroid hormone (PTH)

calcium (Ca)

blood phosphorus (P) and alkaline phosphatase (ALP) levels were analyzed. The improvement of clinical symptoms and complications were observed

and the safety and efficacy of treatment were evaluated.

Results:

After 1 d

1 week

1 month

3 months

6 months and 1 year

the levels of PTH

Ca and P in 2 groups were significantly decreased (

＜0.05)

and the ALP levels were no significant difference before and after operation (

＞0.05). There was no significant difference in postoperative laboratory indexes between 2 groups (

＞0.05). Postoperative muscle weakness

bone pain

skin pruritus and neurological symptoms were significantly improved in both groups. There was 1 case of hoarseness combined with hypocalcemia and 1 case of postoperative intermuscular hematoma after RFA;1 case of hypocalcemia and 1 case of hoarseness after PTX. There were no significant differences between 2 groups (

＞0.05).

Conclusion:

The efficacy of ultrasound-guided RFA in the treatment of SHPT is similar to PTX

which can significantly improve the patients clinical symptoms and quality of life.

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