Value of multi-modal ultrasound in diagnosis of cervical lymph node metastasis of nasopharyngeal carcinoma

FAN Xiao; NIE Fang; WANG Peihua; WANG Lan; Wang Guojuan

doi:10.19732/j.cnki.2096-6210.2021.06.009

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Value of multi-modal ultrasound in diagnosis of cervical lymph node metastasis of nasopharyngeal carcinoma

更新时间：2025-12-15

- Value of multi-modal ultrasound in diagnosis of cervical lymph node metastasis of nasopharyngeal carcinoma
- Vol. 30, Issue 6, Pages: 483-488(2021)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2021.06.009
  CLC：
- Published Online：28 December 2021，
  
  Published：28 December 2021
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范潇,聂芳,王佩华,等. 多模态超声成像对鼻咽癌颈部淋巴结转移的诊断价值[J]. 肿瘤影像学, 2021, 30(6): 483-488 https://doi.

org/10.19732/j.cnki.2096-6210.2021.06.009
范潇,聂芳,王佩华,等. 多模态超声成像对鼻咽癌颈部淋巴结转移的诊断价值[J]. 肿瘤影像学, 2021, 30(6): 483-488 https://doi. DOI： 10.19732/j.cnki.2096-6210.2021.06.009.

org/10.19732/j.cnki.2096-6210.2021.06.009 DOI：

摘要

目的：

探讨多模态超声成像对鼻咽癌（nasopharyngeal carcinoma，NPC）颈部淋巴结转移的诊断价值。

方法：

选取82例NPC患者共计108枚颈部肿大淋巴结，术前对淋巴结行常规超声、应变弹性成像（strain elastography，SE）及超声造影（contrast-enhanced ultrasound，CEUS）检查，依据病理学检查结果将其分为转移组（59枚）、未转移组（49枚）。对比分析两组淋巴结的分区特点、超声特征、SE评分及CEUS特征，评价常规超声、SE、CEUS及多模态超声联合诊断对NPC颈部淋巴结转移的诊断效能。

结果：

① NPC转移组与未转移组淋巴结在分区、有无淋巴门、内部回声、是否有钙化、是否有坏死囊变、血流类型、SE评分、CEUS灌注模式、增强均匀性、增强强度、有无灌注缺损方面的差异均有统计学意义（

均＜0.05）。② 常规超声、SE、CEUS及联合诊断对诊断NPC颈部淋巴结转移的灵敏度分别为79.7%、83.1%、93.2%、94.9%，特异度分别为67.3%、57.1%、77.6%、87.8%，准确度分别为74.1%、71.3%、86.1%、91.7%；多模态超声联合诊断的灵敏度、特异度、准确度均高于单一检查方法。

结论：

多模态超声成像对鉴别NPC颈部肿大淋巴结良恶性有良好的诊断效能，可为诊断NPC颈部淋巴结转移提供更可靠的影像学依据。

Abstract

Objective:

To explore the value of multi-modal ultrasound in diagnosis of cervical lymph node metastasis of nasopharyngeal carcinoma (NPC).

Method:

A total of 108 cervical swollen lymph nodes from 82 NPC patients were selected. They were examined by conventional ultrasound

strain elastography (SE) and contrast-enhanced ultrasound (CEUS)

and were divided into metastatic

group and non-metastatic group according to the pathological results. The zoning characteristics

conventional ultrasound characteristics

SE scores and CEUS characteristics of each group were analyzed. And the diagnostic efficacy of conventional ultrasound

CEUS and multi-modal ultrasound combined diagnosis in diagnosis of cervical lymph node metastasis of NPC were evaluated.

Results:

① There were significant differences between the metastatic group and the non-metastatic group in lymph nodes anatomical regions

internal echo

blood flow types

SE scores

CEUS perfusion pattern

enhancement uniformity

enhancement intensity

and whether there were lymphatic hilum

calcification

necrosis

and perfusion defects (all

＜0.05). ② The sensitivity of conventional ultrasound

CEUS and multi-modal ultrasound combined diagnosis was 79.7%、83.1%、93.2% and 94.9%

respectively; the specificity was 67.3%

57.1%

77.6% and 87.8%

respectively; and the accuracy was 74.1%

71.3%

86.1% and 91.7%

respectively. The sensitivity

specificity and accuracy of the multi-modal ultrasound combined diagnosis were all higher than that of the single examination method.

Conclusion:

Multi-modal ultrasound has a good diagnostic efficacy in differentiating benign and malignant lymph nodes of NPC. It can provide a more reliable imaging basis for the diagnosis of NPC cervical lymph node metastasis.

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