Comparison of ADC <sub>mean</sub> and ADC <sub>min</sub> in preoperative quantitative prediction of poorly differentiated hepatocellular carcinoma: a meta-analysis

WANG Fei; ZOU Tongen; YU Jiang; ZHENG Shaokun; SHEN Zhanrong; YAN Chunyue

doi:10.19732/j.cnki.2096-6210.2021.06.013

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Comparison of ADC _mean and ADC _min in preoperative quantitative prediction of poorly differentiated hepatocellular carcinoma: a meta-analysis

更新时间：2025-12-15

- Comparison of ADC _mean and ADC _min in preoperative quantitative prediction of poorly differentiated hepatocellular carcinoma: a meta-analysis
- Vol. 30, Issue 6, Pages: 504-511(2021)
- 作者机构：
  
  1. 泸州市人民医院医学影像科,四川,泸州,646000
  2. 西南医科大学附属医院妇产科,四川,泸州,646000
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2021.06.013
  CLC：
- Published Online：28 December 2021，
  
  Published：28 December 2021
- 稿件说明：
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王飞,邹同恩,余江,等. 比较ADC _mean 及ADC _min术前定量预测低分化肝细胞癌的meta分析[J]. 肿瘤影像学, 2021, 30(6): 504-511 https://doi.

org/10.19732/j.cnki.2096-6210.2021.06.013
王飞,邹同恩,余江,等. 比较ADC _mean 及ADC _min术前定量预测低分化肝细胞癌的meta分析[J]. 肿瘤影像学, 2021, 30(6): 504-511 https://doi. DOI： 10.19732/j.cnki.2096-6210.2021.06.013.

org/10.19732/j.cnki.2096-6210.2021.06.013 DOI：

摘要

目的：

通过meta分析，探讨磁共振表观弥散系数（apparent diffusion coefficient，ADC）值术前预测肝细胞癌（hepatocellular carcinoma，HCC）组织学病理分级的可行性，并比较ADC平均值（ADC

mean

）及ADC最小值（ADC

min

）术前定量预测低分化HCC的诊断效能。

方法：

检索数据库中关于ADC值对HCC组织学分级（高、中及低分化）诊断价值的相关研究，检索时间为2000年1月 2020年10月。由2名研究人员根据纳入与排除标准独立筛选文献、提取资料，对纳入的研究进行质量评价，并采用统计学软件进行分析汇总。

结果：

共纳入18篇文献，中文7篇，英文11篇，共1 807例HCC（高分化329例，中分化1 048例，低分化430例），不存在发表偏倚（

＞0.1）。高分化

中分化［标准化均数差（standardized mean difference，SMD）=0.98；95% CI：0.57~1.39］，高分化

低分化（SMD=2.19；95% CI：1.60~2.79），中分化

低分化（SMD=1.03；95% CI：0.83~1.23）结果显示，ADC

mean

鉴别高、中、低分化HCC各组间差异均有统计学意义（

＜0.000 01）。ADC

mean

和ADC

min

术前定量预测低分化HCC的合并灵敏度为0.84和0.81（

=-0.186，

=0.852）、特异度为0.81和0.67（

=-0.445，

=0.656）、受试者工作特征曲线的曲线下面积为0.881 5和0.859 8（

=-0.170，

=0.865），差异均无统计学意义。

结论：

ADC

mea

n 及ADC

min

术前定量预测低分化HCC均具有较高的诊断效能，但两者差异无统计学意义；ADC

mean

与HCC组织学病理分化程度正相关，可作为一种可靠、无创的术前定量

预测HCC组织学病理分级的重要手段。

Abstract

Objective:

To investigate the feasibility of magnetic resonance apparent diffusion coefficient (ADC) value in predicting the histopathological grade of hepatocellular carcinoma (HCC) by meta-analysis

and to compare the diagnostic efficacy of ADC mean value (ADC

mean

) and ADC minimum value (ADC

min

) in preoperative quantitative prediction of poorly differentiated HCC.

Methods:

Related researches were researched from January 2000 to October 2020 for studying the diagnostic value of ADC value in the degree of differentiation (well

medium and poor differentiation) of HCC in databases. Two researchers independently screened the literature and extracted data according to the inclusion and exclusion criteria

and evaluated the quality of the included studies. And then the included studies were analyzed with using statistical software.

Results:

Totally 18 up-to-standard literatures (7 in Chinese and 11 in English) were included

including 1 807 HCC columns (329 well differentiated

1 048 moderately differentiated

and 430 poorly differentiated). There was no publication bias in each study (

＞0.1). The results showed high differentiation

medium differentiation ［standardized mean difference (SMD)=0.98; 95% CI: 0.57-1.39］

high differentiation

low differentiation (SMD=2.19; 95% CI: 1.60-2.79)

moderate differentiationvs low differentiation (SMD=1.03; 95% CI: 0.83-1.23). The differences of ADC

mean

in the identification of high

middle and low differentiation HCC groups were statistically significant (

＜0.000 01) . The combined sensitivity

specificity and area under summary receiver operating characteristic curve of ADC

mean

and ADC

min

in preoperative quantitative prediction of poorly differentiated HCC were 0.84 and 0.81 (

=-0.186

=0.852)

0.81 and 0.67 (

=-0.445

=0.656)

0.881 5 and 0.859 8 (

=-0.170

=0.865)

respectively. The difference was not statistically significant.

Conclusion:

The ADC

mean

and ADC

min

had high diagnostic efficiency in preoperative quantitative prediction of poorly differentiated HCC

but there was no significant difference between them. ADC

mean

was positively correlated with the degree of histological and pathological differentiation of HCC

which could be used as a reliable and noninvasive method to quantitatively predict the histological and pathological grading of HCC.

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Comparison of ADC mean and ADC min in preoperative quantitative prediction of poorly differentiated hepatocellular carcinoma: a meta-analysis

DOI：10.19732/j.cnki.2096-6210.2021.06.013

摘要

Abstract

关键词

Keywords

references

Comparison of ADC _mean and ADC _min in preoperative quantitative prediction of poorly differentiated hepatocellular carcinoma: a meta-analysis