Factors influencing the efficacy of percutaneous radiofrequency ablation of thyroid benign nodules

TANG Lina; LIU Hui; DU Zhongshi; WU Zhougui; CHEN Yijie; LIN Ruoxuan; LIN Xiuan; ZHENG Xiong

doi:10.19732/j.cnki.2096-6210.2022.02.015

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Factors influencing the efficacy of percutaneous radiofrequency ablation of thyroid benign nodules　

更新时间：2025-12-15

- Factors influencing the efficacy of percutaneous radiofrequency ablation of thyroid benign nodules　
- Vol. 31, Issue 2, Pages: 197-202(2022)
- 作者机构：
  
  1. 福建医科大学附属肿瘤医院，福建省肿瘤医院超声科,福建,福州,350014
  2. 福建医科大学附属肿瘤医院，福建省肿瘤医院头颈外科,福建,福州,350014
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2022.02.015
  CLC：
- Published Online：28 April 2022，
  
  Published：28 April 2022
- 稿件说明：
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唐丽娜,刘辉,杜忠实,等. 射频消融治疗后甲状腺良性结节疗效的影响因素分析[J]. 肿瘤影像学, 2022, 31(2): 197-202 https://doi.

org/10.19732/j.cnki.2096-6210.2022.02.015
唐丽娜,刘辉,杜忠实,等. 射频消融治疗后甲状腺良性结节疗效的影响因素分析[J]. 肿瘤影像学, 2022, 31(2): 197-202 https://doi. DOI： 10.19732/j.cnki.2096-6210.2022.02.015.

org/10.19732/j.cnki.2096-6210.2022.02.015 DOI：

摘要

目的：

探讨超声引导下射频消融（radiofrequency ablation，RFA）治疗甲状腺良性结节疗效的影响因素。

方法：

回顾并分析2015年12月2017年12月单次RFA治疗甲状腺良性结节的133例（158个结节）患者的临床资料，于治疗后1、3、6、12个月检测结节体积及体积缩小率（volume reduction rate，VRR），比较不同年龄、性别、初始结节大小（体积）、结节成分、消融功率与时间乘积等因素对疗效的影响。

结果：

RFA治疗后1、3、6、12个月结节总缩小率分别为（25.6532.75）%、（57.6620.88）%、（73.6419.92）%和（82.2116.17）%，与治疗前比较差异有统计学意义（

＜0.001）；初始结节体积与治疗后3、6、12个月VRR呈负相关（

＜0.001）；治疗后6、12个月囊实性结节平均VRR分别为（84.4511.98）%和（90.8610.07）%，高于实性结节（

＜0.001）；消融时间及消融功率与时间的乘积与治疗后6、12个月结节VRR存在显著相关性（

=0.002和

=0.02）；不同年龄、性别与结节VRR无相关性（

＞0.05）。

结论：

超声引导下RFA治疗甲状腺良性结节患者疗效满意，结节的初始体积、实性成分及消融功率与时间乘积将对疗效产生影响。

Abstract

Objective:

To explore the influencing factors of ultrasound-guided radiofrequency ablation (RFA) for benign thyroid nodules.

Methods:

The clinical data of patients with thyroid benign nodules treated with RFA from December 2015 to December 2017 were retrospectively analyzed. After 1

6 and 12 months of treatment

nodule volume and volume reduction rate (VRR) wer

e detected. The effects of different age

sex

initial nodule size (volume)

nodule composition

ablation time

power and powertime product on the curative effect were compared.

Results:

The total VRR of nodules at 1

and 12 months after RFA were (25.6532.75)%

(57.6620.88)%

(73.6419.92)%

and (82.2116.17)%

respectively (

＜0.001). The initial nodule volume was negatively correlated with VRR of 3

6 and 12 months after RFA (

＜0.001). The mean VRR of cystic and solid nodules were (84.4511.98)% and (90.86 10.07)%

which were higher than those of solid nodules at 6 months and 12 months after RFA (

＜0.001). The ablation time and the product of ablation power and time were significantly correlated with the VRR at 6 and 12 months after RFA (

=0.002 and

=0.02). There was no correlation between different age

gender and VRR (

＞0.05).

Conclusion:

Ultrasound-guided RFA of benign thyroid nodules is a safe and effective minimally invasive treatment. Nodule size

solid components

ablation time and the product of ablation power and time are related to VRR after RFA.

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