Research progress in clinical application of nuclear medicine molecular probes for gastroenteropancreatic neuroendocrine neoplasm

LIU Yu; LIU Meixi; ZHU Wenjia; HUO Li

doi:10.19732/j.cnki.2096-6210.2022.03.002

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Research progress in clinical application of nuclear medicine molecular probes for gastroenteropancreatic neuroendocrine neoplasm

更新时间：2025-12-15

- Research progress in clinical application of nuclear medicine molecular probes for gastroenteropancreatic neuroendocrine neoplasm
- Vol. 31, Issue 3, Pages: 222-229(2022)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2022.03.002
  CLC：
- Published Online：28 June 2022，
  
  Published：28 June 2022
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刘宇,刘玫汐,朱文佳,等. 胃肠胰神经内分泌肿瘤核医学分子探针临床应用研究进展[J]. 肿瘤影像学, 2022, 31(3): 222-229 https://doi.

org/10.19732/j.cnki.2096-6210.2022.03.002
刘宇,刘玫汐,朱文佳,等. 胃肠胰神经内分泌肿瘤核医学分子探针临床应用研究进展[J]. 肿瘤影像学, 2022, 31(3): 222-229 https://doi. DOI： 10.19732/j.cnki.2096-6210.2022.03.002.

org/10.19732/j.cnki.2096-6210.2022.03.002 DOI：

摘要

神经内分泌肿瘤（neuroendocrine neoplasm，NEN）是一组以神经内分泌分化为特征的上皮性肿瘤，最常见的发生部位是胃肠胰。胃肠胰NEN（gastroenteropancreatic NEN，GEP-NEN）起病隐匿，影像学特征不明显，任何分级均可出现远处转移，是临床诊断和治疗的难点。核医学利用放射性核素标记的分子探针，针对GEP-NEN不同的靶点进行显像，提高了病灶的检出率和诊断准确度。本文就生长抑素受体（somatostatin receptor，SSTR）激动剂、SSTR拮抗剂、

F-FDG、

F-DOPA、胰高血糖素样肽-1受体激动剂、趋化因子配体和成纤维细胞活化蛋白抑制剂等核医学分子探针在GEP-NEN的临床应用研究进展作一述评。

Abstract

Neuroendocrine neoplasms (NENs) are a group of epithelial tumors characterized by neuroendocrine differentiation

the most common type being gastroenteropancreatic NENs (GEP-NENs). GEP-NENs have insidious onset

and their imaging features are not obvious. Distant metastases can occur in GEP-NENs with different degrees of malignancy

leading to difficulties in clinical diagnosis and treatment. Based on different targets in GEP-NENs

radionuclide-labeled molecular probes improve the detection rate of lesions and the accuracy of diagnosis. In this paper

we reviewed the research progress of nuclear medicine molecular probes

including somatostatin receptor (SSTR) agonists

SSTR antagonists

F-FDG

F-DOPA

glucagon-like peptide-1 receptor agonists

chemokine ligands

and fibroblast-activation-protein inhibitor in the clinical application of GEP-NENs.

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