A comparative study of&nbsp; <sup>68 </sup>Ga-DOTATATE PET/CT and&nbsp; <sup>1</sup>8 F-FDG PET/CT in imaging of well-differentiated versus poorly differentiated gastroenteropancreatic neuroendocrine neoplasm

TANG Wenxin; WANG Qixin; YANG Songsong; LIU Hanxiang; PENG Dengsai; CHEN Yue

doi:10.19732/j.cnki.2096-6210.2022.03.003

您当前的位置：

首页 >

文章列表页 >

A comparative study of ⁶⁸Ga-DOTATATE PET/CT and ¹8 F-FDG PET/CT in imaging of well-differentiated versus poorly differentiated gastroenteropancreatic neuroendocrine neoplasm

更新时间：2025-12-15

- A comparative study of ⁶⁸Ga-DOTATATE PET/CT and ¹8 F-FDG PET/CT in imaging of well-differentiated versus poorly differentiated gastroenteropancreatic neuroendocrine neoplasm
- Vol. 31, Issue 3, Pages: 230-235(2022)
- 作者机构：
  
  1. 四川省院士（专家）工作站,四川,泸州,646000
  2. 西南医科大学附属医院核医学科,四川,泸州,646000
  3. 四川省核医学与分子影像重点实验室,四川,泸州,646000
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2022.03.003
  CLC：
- Published Online：28 June 2022，
  
  Published：28 June 2022
- 稿件说明：
移动端阅览
唐文鑫,王琦新,杨松松,等. ⁶⁸ Ga-DOTATATE PET/CT与 ¹⁸ F-FDG PET/CT对分化良好和分化不良的胃肠胰神经内分泌肿瘤显像的对比研究[J]. 肿瘤影像学, 2022, 31(3): 230-235 https://doi.

org/10.19732/j.cnki.2096-6210.2022.03.003
唐文鑫,王琦新,杨松松,等. ⁶⁸ Ga-DOTATATE PET/CT与 ¹⁸ F-FDG PET/CT对分化良好和分化不良的胃肠胰神经内分泌肿瘤显像的对比研究[J]. 肿瘤影像学, 2022, 31(3): 230-235 https://doi. DOI： 10.19732/j.cnki.2096-6210.2022.03.003.

org/10.19732/j.cnki.2096-6210.2022.03.003 DOI：

摘要

目的：

对比评估 68 Ga-DOTATATE正电子发射体层成像（positron emission tomography，PET）/计算机体层成像（computed tomography，CT）与

F-FDG PET/CT对分化良好和分化不良胃肠胰神经内分泌肿瘤（gastroenteropancreatic neuroendocrine neoplasm，GEP-NEN）的诊断效能。

方法：

回顾并分析2018年12月2022年1月于西南医科大学附属医院经病理学检查确诊为GEP-NEN的71例患者（男性32例，女性39例，中位年龄54岁）的临床病理学资料及

Ga-DOTATATE、

F-FDG PET/CT显像结果。将患者分为分化良好组及分化不良组，对上述两组患者的

Ga-DOTATATE PET/CT及

F-FDG PET/CT显像阳性率、病灶（原发及转移性）显示数量进行统计对比。

结果：

分化良好组

Ga-DOTATATE PET/CT及

F-FDG PET/CT显像阳性率分别为80.6%及48.4%，差异有统计学意义（

=14.091，

＜0.05），病灶显示数量差异无统计学意义（

=2.116，

=0.169）。分化不良组

Ga-DOTATATE PET/CT及

F-FDG PET/CT显像阳性率分别为55.6%及100.0%，差异无统计学意义（

=0.082），病灶显示数量差异无统计学意义（

=1.0）。对于本研究中所有GEP-NEN患者，

Ga-DOTATATE PET/CT显像阳性率为77.5%（55/71），

F-FDG PET/CT显像阳性率为54.9%（39/71），

8 Ga-DO

TATATE PET/CT显像阳性率更高。结论：对于不同分化程度的GEP-NEN，

F-FDG PET/CT及

Ga-DOTATATE PET/CT显像效能不同，但发挥着互补的作用。不同分化程度的NEN患者均可有生长抑素受体（somatostatin receptor，SSTR）高表达，表明其有望从肽受体放射性核素疗法（peptide radionuclide receptor therapy，PRRT）中获益。

Abstract

Objective:

To investigate the diagnostic efficiency of

Ga-DOTATATE positron emission tomography (PET)/computed tomography (CT) in comparison to

8 F-FDG PET/CT in patients with well-differentiated versus poorly differentiated gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN).

Methods:

From December 2018 to January 2022

71 patients (32 males

39 females

median age 54) with GEP-NEN proved by pathology in The Affiliated Hospital of Southwest Medical University who underwent both

Ga-DOTATATE PET/CT and

F-FDG PET/CT scan were retrospectively analyzed. The patients were divided into two groups

well-differentiated group and poorly differentiated group. The positive rate of

Ga-DOTATATE PET/CT and

F-FDG PET/CT scan in the above two groups of patients

and the number of primary and metastatic lesions were evaluated.

Results:

In the well-differentiated group

the positive rates of

Ga-DOTATATE and

F-FDG scan were 80.6% and 48.4%

which reached statistical significance (

=14.091

0.05)

and there was no significant difference in the number of detected lesions between

Ga-DOTATATE and

F-FDG PET/CT (

=2.116

=0.169). In the poorly differentiated group，the positive rate of

Ga-DOTATATE and

F-FDG scan were 55.6% and 100.0%

which did not reach statistical significance (

=0.082)

and there was no significant difference in the number of detected lesions between

Ga-DOTATATE and

F-FDG PET/CT (

.0). In both well-differentiated and poorly differentiated group

Ga-DOTATATE PET/CT did not significantly differ from

F-FDG PET/CT in identifying primary and distant lesions. In all patients with GEP-NEN in this study

Ga-DOTATATE PET/CT were positive in 77.5% （55/71）patients

F-FDG PET/CT were positive in 54.9%（39/71）patients

which indicate the positive rate of

Ga-DOTATATE PET/CT is higher in comparison to that in

F-FDG PET/CT.

Conclusion:

For GEP-NEN with different degrees of differentiation

F-FDG PET/CT and

Ga-DOTATATE PET/CT performances are different

but they play complementary roles. NEN patients with different degrees of differentiation can have high somatostatin receptor (SSTR) expression

indicating that they are expected to benefit from peptide radionuclide receptor therapy (PRRT).

关键词

Keywords

references

Views

1932

下载量

CNKI被引量

Alert me when the article has been cited

提交

Tools

Publicity Resources

Computer-aided design of a novel HER2-targeted cyclic peptide PET probe and its evaluation for noninvasive imaging of breast cancer

Multi-region radiomics features from enhanced CT combined with clinical risk factors for preoperative prediction of lymphovascular invasion in colon cancer

A comparative study of ⁶⁸Ga-TBM-001 PET/CT and ^99mTc-MDP bone scintigraphy in the diagnosis of bone metastases of prostate cancer

Site-specific development and preclinical evaluation of ⁶⁸Ga-THP-ACN376, a CLDN18.2-targeted nanobody probe

Application value of multimodal imaging technology based on CT and MRI in the diagnosis and PRETEXT staging of childhood hepatoblastoma

Related Author

GUO Xu

GAO Xiaomin

YAO Ying

Wanping LI

Wenbin ZHENG

Dan SU

Taoming DU

Yue CHEN

Related Institution

Department of Pharmacy, Wuxi Maternal and Child Health Care Hospital

Wuxi Medical College, Jiangnan University

Department of Pharmacy, Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical University

Department of Radiology, The Second Affiliated Hospital of Shantou University Medical College

Department of Radiology, Puning People's Hospital, Puning

AI问答

⁰

A comparative study of 68 Ga-DOTATATE PET/CT and 18 F-FDG PET/CT in imaging of well-differentiated versus poorly differentiated gastroenteropancreatic neuroendocrine neoplasm

DOI：10.19732/j.cnki.2096-6210.2022.03.003

摘要

Abstract

关键词

Keywords

references

A comparative study of ⁶⁸Ga-DOTATATE PET/CT and ¹8 F-FDG PET/CT in imaging of well-differentiated versus poorly differentiated gastroenteropancreatic neuroendocrine neoplasm