The feature analysis of&nbsp; <sup>68</sup> Ga-somatostatin analogue PET/CT for bone metastasis of neuroendocrine neoplasm

XU Junyan; XU Xiaoping; SONG Shaoli

doi:10.19732/j.cnki.2096-6210.2022.03.004

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The feature analysis of ⁶⁸ Ga-somatostatin analogue PET/CT for bone metastasis of neuroendocrine neoplasm

更新时间：2025-12-15

- The feature analysis of ⁶⁸ Ga-somatostatin analogue PET/CT for bone metastasis of neuroendocrine neoplasm
- Vol. 31, Issue 3, Pages: 236-242(2022)
- 作者机构：
  
  1. 上海分子影像探针工程技术研究中心,上海,200032
  2. 复旦大学附属肿瘤医院核医学科，复旦大学上海医学院肿瘤学系,上海,200032
  3. 复旦大学生物医学影像研究中心,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2022.03.004
  CLC：
- Published Online：28 June 2022，
  
  Published：28 June 2022
- 稿件说明：
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徐俊彦,许晓平,宋少莉. 神经内分泌肿瘤骨转移生长抑素受体PET/CT显像特征分析[J]. 肿瘤影像学, 2022, 31(3): 236-242 https://doi.

org/10.19732/j.cnki.2096-6210.2022.03.004
徐俊彦,许晓平,宋少莉. 神经内分泌肿瘤骨转移生长抑素受体PET/CT显像特征分析[J]. 肿瘤影像学, 2022, 31(3): 236-242 https://doi. DOI： 10.19732/j.cnki.2096-6210.2022.03.004.

org/10.19732/j.cnki.2096-6210.2022.03.004 DOI：

摘要

目的：

探讨生长抑素受体正电子发射体层成像（positron emission tomography，PET）/计算机体层成像（computed tomography，CT）在神经内分泌肿瘤（neuroendocrine neoplasm，NEN）骨转移诊断中的价值及其图像特征。

方法：

回顾并分析2019年8月2021年12月于复旦大学附属肿瘤医院接受

Ga标记的生长抑素类似物（

Ga-somatostatin analogue，

Ga-SSA）PET/CT的NEN骨转移患者的临床及影像学资料。阳性骨病灶定义为显像剂摄取高于正常骨的局限性病灶，测量其最大标准摄取值（maximum standard uptake value，SUV

max

）。根据显像剂种类、肿瘤起源、病理学分级及骨密度改变等进行分析，分别用非独立样本

检验及方差分析比较不同组间SUV

max

的差异。

结果：

1 041例接受

Ga-SSA PET/CT显像的NEN患者中，105例（10.1%）最终诊断为NEN骨转移，其中36例行

Ga-DOTATATE PET/CT，69例行

Ga-DOTANOC PET/CT，显像阳性探测率分别为88.9%和76.8%（

=0.191）。原发肿瘤为胰腺NEN的占26.7%（28/105），为直肠NEN的占20.0%（21/105）。大部分发生骨转移的NEN为NET G2，以成骨性转移为主。

Ga-DOTATATE与

Ga-DOTANOC显像骨阳性病灶的SUV

max

差异无统计学意义（17.019.6

24.631.4，

=0.216）。根据肿瘤原发部位分为胃肠胰NEN组、纵隔/肺NEN组和嗜铬细胞瘤/副神经节瘤组，3组骨转移灶的SUV

max

分别为18.7217.44、15.8121.17和45.8766.88，3组间差异有统计学意义（

=3.867，

=0.025）。

结论：

生长抑素受体显像是诊断NEN骨转移的灵敏方法，

Ga-DOTATATE和

Ga-DOTANOC PET/CT对骨转移的诊断效能差异无统计学意义。NEN骨转移最常见于胃肠胰NET G2，以成骨性转移多见，嗜铬细胞瘤/副神经节瘤骨转移灶显像剂摄取最高。

Abstract

Objective:

To discuss the diagnostic efficiency and imaging features of somatostatin receptor positron emission tomography (PET)/computed tomography (CT) for bone metastasis of neuroendocrine neoplasm (NEN).

Methods:

Clinical characteristics and PET/CT features of NEN patients with bone metastasis in Fudan University Shanghai Cancer Center were retrospectively analyzed. Positive lesions on PET/CT were defined as focal significant uptake which was higher than background of normal bone. Maximum standard uptake value (SUV

max

) of positive lesions was measured. The difference of SUV

max

was compared by independent sample t test and One-Way ANOVA grouped by tracer species

primary tumor

pathological grade and bone change.

Results:

105 cases (10.1%) were finally diagnosed as bone metastasis of NEN in 1 041 patients with NEN who underwent 68 Ga-SSA PET/CT. In this study

36 cases underwent 68 Ga-DOTATATE PET/CT

69 cases underwent

Ga-DOTANOC PET/CT. The detective rates were 88.9% and 76.8% for

Ga-DOTATATE and

Ga-DOTANOC (

=0.191). The most common primary tumor of bone metastasis is pancreatic NEN (28/105

26.7%) and secondly rectal NEN (21/105

20.0%). Bone metastasis mostly originated from NET G2 and presented as osteoblastic changes. There was no significant difference of SUV

max

of bone metastasis on

Ga-DOTATATE and

Ga-DOTANOC PET/CT (17.019.6

24.631.4

=0.216). SUV

max

of bone metastasis showed significant difference among gastroenterpancreatic NEN

thymic/pulmonary NEN and phaochromocytoma/paraganglioma 18.7217.44

15.8121.17 and 45.8766.88 (

=3.867

=0.025).

Conclusion:

Somatostatin receptor PET/CT shows high sensitiv

ity of detecting bone metastasis of NEN.

Ga-DOTATATE and

Ga-DOTANOC PET/CT presents similar diagnostic efficiency. Bone metastasis mostly originated from gastroenterpancreatic NEN and commonly manifested as osteoblastic changes. Highest radioactivity of

Ga-SSA was observed in bone metastasis from phaochromocytoma/paraganglioma.

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The feature analysis of 68 Ga-somatostatin analogue PET/CT for bone metastasis of neuroendocrine neoplasm

DOI：10.19732/j.cnki.2096-6210.2022.03.004

摘要

Abstract

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references

The feature analysis of ⁶⁸ Ga-somatostatin analogue PET/CT for bone metastasis of neuroendocrine neoplasm