Effect of initial b values on stretched-exponential model diffusion-weighted imaging parameters of prostate cancer

LIU Le; LIU Wei; ZHOU Bingni; WANG Yaoshen; QIAN Min; ZHOU Liangping; LIU Xiaohang

doi:10.19732/j.cnki.2096-6210.2022.03.017

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Effect of initial b values on stretched-exponential model diffusion-weighted imaging parameters of prostate cancer

更新时间：2025-12-15

- Effect of initial b values on stretched-exponential model diffusion-weighted imaging parameters of prostate cancer
- Vol. 31, Issue 3, Pages: 323-329(2022)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2022.03.017
  CLC：
- Published Online：28 June 2022，
  
  Published：28 June 2022
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刘乐,刘伟,周冰妮,等. 起始b值对前列腺癌拉伸指数模型弥散加权成像参数的影响[J]. 肿瘤影像学, 2022, 31(3): 323-329 https://doi.

org/10.19732/j.cnki.2096-6210.2022.03.017
刘乐,刘伟,周冰妮,等. 起始b值对前列腺癌拉伸指数模型弥散加权成像参数的影响[J]. 肿瘤影像学, 2022, 31(3): 323-329 https://doi. DOI： 10.19732/j.cnki.2096-6210.2022.03.017.

org/10.19732/j.cnki.2096-6210.2022.03.017 DOI：

摘要

目的：

探讨起始

值对前列腺癌拉伸指数模型（stretched-exponential model，SEM）弥散加权成像（diffusion-weighted imaging，DWI）参数的影响。

方法：

共39例前列腺癌患者在3.0 T磁共振成像（magnetic resonance imaging，MRI）上行多

值（0、300、600、900、1 200、2 000 s/mm

）DWI检查。按

值组合方案（A方案，

值为0、300、1 200、2 000；B方案，

值为0、600、1 200、2 000 s/mm

；C方案，

值为0、900、1 200、2 000 s/mm

；D方案，

值为0、300、600、900、1 200、2 000 s/mm

）计算前列腺癌和正常周围区（peripheral zone，PZ）组织的表观弥散系数（apparent diffusion coefficient，ADC）、分布弥散系数（distributed-diffusion coefficient，DDC）和异质性指数（

）。采用t检验比较同一方案内不同组织的参数间的差异，采用配对

检验对于每个组织在不同方案中的参数进行两两比较。采用受试者工作特征曲线的曲线下面积（area under curve，AUC）比较诊断效果。

结果：

ADC和DDC值随方案改变而变化，但不影响诊断效能。A方案前列腺癌的值高于PZ组织，其他方案中PZ组织的

值均高于前列腺癌（

＜0.05）。A、B方案

值鉴别PZ组织与前列腺癌的AUC（0.91和0.91）显著低于其他参数（AUC＞0.95，

＜0.05）。其他参数鉴别PZ组织与前列腺癌的AUC差异无统计学意义。

结论：

起始

值影响SEM DWI的

值及其对前列腺癌的诊断。

Abstract

Objective:

To investigate the effect of

initial b values on stretched-exponential model (SEM) diffusion-weighted imaging parameters of prostate cancer.

Methods:

Thirty-nine patients with prostate cancer performed 3.0 T magnetic resonance imaging (MRI) scans with multiple

value (0

300

600

900

1 200

2 000 s/mm

) DWI. Parameters

including apparent diffusion coefficient (ADC)

distributed-diffusion coefficient (DDC)

and intravoxel heterogeneity index (

)

were calculated using protocols A-D (

value ranges: A 0

300

1 200

2 000 s/mm

; B 0

600

1 200

2 000 s/mm

; C 0

900

1 200

2 000 s/mm

; D 0

300

600

900

1 200

2 000 s/mm

). For each tissue ［peripheral zone (PZ) and cancer］

parameters were compared across protocols with paired t test. In each protocol

each parameter was compared between cancer and PZ tissues using one-way analysis of variance. The diagnostic efficacy was evaluated by area under receiver operating characteristic curve (AUC).

Results:

The ADC

DDC values varied in different protocols

but did not affect the diagnosis performance. The

value of cancer in protocol A was higher than PZ tissues

but in other protocols

values of PZ tissues were higher than cancer (

＜0.05). The AUC of

value in protocols A

B (0.91 and 0.91) to differentiating PZ tissues and prostate cancer was significantly lower than those of the other parameters (AUC＞0.95

＜0.05). And there were no significantly difference among the AUCs of other parameters in differentiating cancer and PZ tissues.

Conclusion:

Changing of initial

values affected the

value and its diagnostic performance for prostate cancer.

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