Research progress of amide proton transfer imaging in preoperative grading and postoperative recurrence assessment of glioma

ZHANG Hanwen; LEI Yi; LIN Fan

doi:10.19732/j.cnki.2096-6210.2022.03.020

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Research progress of amide proton transfer imaging in preoperative grading and postoperative recurrence assessment of glioma

更新时间：2025-12-15

- Research progress of amide proton transfer imaging in preoperative grading and postoperative recurrence assessment of glioma
- Vol. 31, Issue 3, Pages: 340-344(2022)
- 作者机构：
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- DOI：10.19732/j.cnki.2096-6210.2022.03.020
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- Published Online：28 June 2022，
  
  Published：28 June 2022
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张瀚文,雷益,林帆. 氨基质子转移成像在胶质瘤术前分级及术后复发评估中的相关研究进展[J]. 肿瘤影像学, 2022, 31(3): 340-344 https://doi.

org/10.19732/j.cnki.2096-6210.2022.03.020
张瀚文,雷益,林帆. 氨基质子转移成像在胶质瘤术前分级及术后复发评估中的相关研究进展[J]. 肿瘤影像学, 2022, 31(3): 340-344 https://doi. DOI： 10.19732/j.cnki.2096-6210.2022.03.020.

org/10.19732/j.cnki.2096-6210.2022.03.020 DOI：

摘要

胶质瘤是最常见的颅内原发恶性肿瘤。氨基质子转移成像（amide proton transfer imaging，APT）是目前一种以磁共振平扫方式反映肿瘤内多肽及蛋白质的氨基质子与水中的氢离子转运水平的技术，可以较为准确地反映肿瘤内的蛋白质水平、pH值等相关信息。在国内外已被广泛应用于胶质瘤的手术前后病情判断研究。本文将国内外该领域的研究进展作一简要综述。

Abstract

Glioma is the most common primary malignant tumor in the brain. Amide proton transfer imaging (APT) is a technique that reflects the level of amide proton transport with hydrogen ions in water for peptides and proteins within the tumor by using magnetic resonance imaging without contrast administration. This technique can more accurately reflect the protein level

pH value and other relevant information within the tumor. Nowadays

APT is widely used in the research of glioma. In this paper

we briefly described the research progress of this technique in China and abroad.

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Related Institution

Graduate Training Base of Wenzhou Medical University, Zhejiang Cancer Hospital

Wenling Institute of Medical Big Data and Artificial Intelligence

Department of Ultrasound, Zhejiang Cancer Hospital

The Second Clinical College of Zhejiang Chinese Medicine University

Department of Radiotherapy, Huashan Hospital, Fudan University

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