Clinical application of CEUS in evaluation of the efficacy of local thermal ablation of hepatocellular carcinoma

WANG Kun; DONG Yi; LIU Lingxiao; CHEN Rongxin; Bao Jingwen; CHEN Yanling; WANG Wenping

doi:10.19732/j.cnki.2096-6210.2022.04.011

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Clinical application of CEUS in evaluation of the efficacy of local thermal ablation of hepatocellular carcinoma

更新时间：2025-12-15

- Clinical application of CEUS in evaluation of the efficacy of local thermal ablation of hepatocellular carcinoma
- Vol. 31, Issue 4, Pages: 414-418(2022)
- 作者机构：
  
  1. 复旦大学附属中山医院超声科,上海,200032
  2. 复旦大学附属中山医院介入治疗科,上海,200032
  3. 复旦大学附属中山医院肝肿瘤内科,上海,200032
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2022.04.011
  CLC：
- Published Online：28 August 2022，
  
  Published：28 August 2022
- 稿件说明：
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王坤,董怡,刘凌晓,等. CEUS在肝细胞肝癌局部热消融疗效评估中的临床应用价值[J]. 肿瘤影像学, 2022, 31(4): 414-418 https://doi.

org/10.19732/j.cnki.2096-6210.2022.04.011
王坤,董怡,刘凌晓,等. CEUS在肝细胞肝癌局部热消融疗效评估中的临床应用价值[J]. 肿瘤影像学, 2022, 31(4): 414-418 https://doi. DOI： 10.19732/j.cnki.2096-6210.2022.04.011.

org/10.19732/j.cnki.2096-6210.2022.04.011 DOI：

摘要

目的：

分析研究超声造影（contrast-enhanced ultrasound，CEUS）在肝细胞肝癌（hepatocellular carcinoma，HCC）患者热消融治疗术后评估中的临床应用价值。

方法：

前瞻性收集2021年511月于复旦大学附属中山医院肝肿瘤内科及介入治疗科行热消融治疗的44例HCC患者（射频消融19例，微波消融25例），病灶最大径9~42 mm，平均18.1 mm，术前CEUS准确定位引导病灶热消融，术后1个月行CEUS及钆塞酸二钠（Gd-EOB-DTPA）增强磁共振成像（magnetic resonance imaging，MRI）检查，以Gd-EOB-DTPA增强MRI检查结果为标准，将CEUS评价热消融治疗的结果与标准进行比较，分析两种影像学方法判断肿瘤灭活的诊断符合率。

结果：

本组HCC热消融术后，CEUS、Gd-EOB-DTPA增强MRI评估热消融后病灶大小的比较差异无统计学意义（

=0.574）。经Gd-EOB-DTPA增强MRI提示病灶完全消融40例，不完全消融4例；经CEUS检查提示病灶完全消融41例，不完全消融3例。术后1个月CEUS评估HCC消融后疗效判断的准确度、灵敏度及特异度分别为97.7%、75.0%、100.0%。

结论：

CEUS对HCC患者热消融治疗后的评价具有较高的准确度、灵敏度和特异度，可以将其作为HCC患者热消融治疗效果评价的手段。

Abstract

Objective:

To analyze the clinical value of contrast-enhanced ultrasound (CEUS) in the evaluation of patients with hepatocellular carcinoma (HCC) after thermal ablation.

Methods:

A total of 44 patients with HCC treated by radiofrequency ablation (19 cases) and microwave ablation (25 cases) were prospectively collected from May 2021 to November 2021 in De

partment of Hepatology and Interventional Surgery

Zhongshan Hospital Affiliated to Fudan University. The maximum diameter of the lesion was 9-42 mm

with an average of 18.1 mm. The thermal ablation of the lesion was guided by preoperative CEUS accurately. One month after the operation

CEUS and Gd-EOB-DTPA enhanced magnetic resonance imaging (MRI) were performed. The result of Gd-EOB- DTPA enhanced MRI examination was taken as the gold standard. The result of CEUS evaluation of thermal ablation treatment was compared with the gold standard. And the diagnostic coincidence rate of tumor inactivation by two imaging methods was analyzed.

Results:

After thermal ablation

there was no significant difference in lesion size between CEUS and Gd-EOB-DTPA enhanced MRI assessment (

=0.574). The Gd-EOB-DTPA enhanced MRI showed complete ablation in 40 cases and incomplete ablation in 4 cases. CEUS showed complete ablation in 41 cases and incomplete ablation in 3 cases. The accuracy

sensitivity and specificity of CEUS after operation were 97.7%

75.0% and 100.0%

respectively.

Conclusion:

CEUS has high accuracy

sensitivity and specificity in theevaluation of thermal ablation for HCC patients

and can be used to evaluating the efficacy of thermal ablation for HCC patients.

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