Research progress on the correlation between molecular markers and ultrasound features in papillary carcinoma of the thyroid

上海交通大学医学院附属瑞金医院超声科; 上海

doi:10.19732/j.cnki.2096-6210.2022.05.001

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Research progress on the correlation between molecular markers and ultrasound features in papillary carcinoma of the thyroid

更新时间：2025-12-15

- Research progress on the correlation between molecular markers and ultrasound features in papillary carcinoma of the thyroid
- Vol. 31, Issue 5, Pages: 457-462(2022)
- 作者机构：
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- DOI：10.19732/j.cnki.2096-6210.2022.05.001
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- Published Online：28 October 2022，
  
  Published：28 October 2022
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上海交通大学医学院附属瑞金医院超声科,上海. 甲状腺乳头状癌分子标志物与超声特征相关性研究进展[J]. 肿瘤影像学, 2022, 31(5): 457-462 https://doi.

org/10.19732/j.cnki.2096-6210.2022.05.001
上海交通大学医学院附属瑞金医院超声科,上海. 甲状腺乳头状癌分子标志物与超声特征相关性研究进展[J]. 肿瘤影像学, 2022, 31(5): 457-462 https://doi. DOI： 10.19732/j.cnki.2096-6210.2022.05.001.

org/10.19732/j.cnki.2096-6210.2022.05.001 DOI：

摘要

甲状腺乳头状癌（papillary carcinoma of the thyroid，PTC）是最常见的甲状腺分化型肿瘤，其发生主要与

BRAF

、

RAS

、

RET

、

TERT

等癌基因的突变密切相关。不同癌基因的改变可能会导致PTC出现不同的生物学行为和肿瘤生长模式，呈现出不同的超声特征。近年来，随着分子生物学技术的发展，许多研究者尝试探索PTC分子标志物与超声特征的相关性。充分了解PTC分子标志物与超声特征之间的关联，可以在有创操作前更好地评估PTC患者的总体风险和可能存在的分子特征，这将有助于PTC的个性化评估，对于合理制订患者后续的诊疗方案至关重要。

Abstract

Papillary carcinoma of the thyroid (PTC) is the most common differentiated thyroid tumor. Its occurrence is closely associated with mutations in oncogenes such as

BRAF

RAS

RET

and

TERT

. Different oncogene mutations may result in biological behaviors and tumor growth patterns of PTC that exhibit various ultrasound features. With the progression of molecular biology technology in recent years

number of researchers have attempted to investigate the correlation between PTC molecular markers and ultrasound features. A thorough understanding of the relationship between PTC molecular markers and ultrasound features can helpassess the overall risk and potential molecular characteristics. This will contribut

e to an individualized assessment of PTC and is essential to the logical formulation of the follow-up diagnosis and treatment plan.

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