The volumetric ROI histogram based on DWI with high<em> b</em> value in differentiating prostatic carcinoma from benign prostatic hyperplasia in central gland

ZHANG Zhe; LAN Xiuling; SHEN Lin; BAI Xiuyan; FANG Xiao

doi:10.19732/j.cnki.2096-6210.2022.05.011

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The volumetric ROI histogram based on DWI with high b value in differentiating prostatic carcinoma from benign prostatic hyperplasia in central gland

更新时间：2025-12-15

- The volumetric ROI histogram based on DWI with high b value in differentiating prostatic carcinoma from benign prostatic hyperplasia in central gland
- Vol. 31, Issue 5, Pages: 523-530(2022)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2022.05.011
  CLC：
- Published Online：28 October 2022，
  
  Published：28 October 2022
- 稿件说明：
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张喆,兰秀玲,申林,等. 基于高b值DWI的容积ROI直方图鉴别中央腺体前列腺癌与良性前列腺增生的价值[J]. 肿瘤影像学, 2022, 31(5): 523-530 https://doi.

org/10.19732/j.cnki.2096-6210.2022.05.011
张喆,兰秀玲,申林,等. 基于高b值DWI的容积ROI直方图鉴别中央腺体前列腺癌与良性前列腺增生的价值[J]. 肿瘤影像学, 2022, 31(5): 523-530 https://doi. DOI： 10.19732/j.cnki.2096-6210.2022.05.011.

org/10.19732/j.cnki.2096-6210.2022.05.011 DOI：

摘要

目的：

探讨高

值磁共振弥散加权成像（diffusion-weighted imaging，DWI）的表观弥散系数（apparent diffusion coefficient，ADC）的容积感兴趣区（volumetric region of interest，vROI）直方图鉴别中央腺体（central gland，CG）前列腺癌（prostatic carcinoma，PCa）与良性前列腺增生（benign prostatic hyperplasia，BPH）的价值。

方法：

回顾并分析2017年3月2021年7月于辽阳辽化医院经前列腺标准

值（

=800 s/mm

）和高

值（

=1 500 s/mm

）DWI扫描且经病理学检查证实的59例PCa患者（62个病灶）和80例BPH患者（80个病灶）。在美国GE公司的AW4.6工作站上对标准

值和高

值的DWI图进行后处理，分别获得ADC

800

和ADC

1 500

。利用Fire Voxel软件，分别在ADC

800

和ADC

1 500

图像的每一层面沿着病灶边缘勾画ROI，再将这些ROI融合成vROI。随后对vROI进行直方图分析，获得直方图参数ADC

800-mean、std、min、1th、5th、10th、25th、50th、75th、90th、95th、max、ske、kur

和ADC

1 500-mean、std、min、1th、5th、10th、25th、50th、75th、90th、95th、max、ske、kur

。采用组内相关系数（interclass correlation coefficient，ICC）检验2名医师所测结果的一致性；采用独立样本t检验或Mann-Whitney

检验比较各参数的差异；绘制受试者工作特征（receiver operating characteristic，ROC）曲线，评价诊断效能，采用DeLong检验比较两种b值所得参数的曲线下面积（area under curve，AUC）的差异。

结果：

2名医师测得结

果一致性良好（ICC＞0.75）；PCa的ADC

800-min、5th、10th、25th 、

ADC

1 500-mean、min、5th、10th、25th、50th

低于BPH；ADC

1 500-mean、min、5th、10th

的AUC高于相应的直方图参ADC

800-mean、min、5th、10th

，差异有统计学意义（

＜0.05）。

结论：

基于高b值的DWI的vROI直方图能够鉴别发生于CG的PCa和BPH，其诊断效能高于基于标准

值所得结果。

Abstract

Objective:

To explore the volumetric region of interest (vROI) histogram of apparent diffusion coefficient (ADC) of diffusion-weighted imaging (DWI) with high b value to differentiate prostatic carcinoma (PCa) from benign prostatic hyperplasia (BPH) in central gland (CG).

Methods:

A total of 59 PCa patients (62 lesions) and 80 BPH patients (80 lesions) confirmed by pathology in CG were retrospectively analyzed

who preoperatively underwent DWI scanning with standard

value (

=800 s/mm

) and high

value (

=1 500 s/mm

) in Liaoyang Liaohua Hospital from March 2017 to July 2021. In GE AW4.6 workstation

the DWI (

=800 s/mm

and

=1 500 s/mm

) were post-processed to obtain the ADC

800

and ADC

1 500

. In Fire Voxel software

the ROIs were drawn along the edge of lesion on each layer of ADC

800

and ADC

1 500

image and merged into a vROI respectively. The histogram analysis of vROI was performed to obtain parameters

which including ADC

800-mean、std、min、1th、5th、10th、25th、50th、75th、90th、95th、max、ske、kur

and ADC

1 500-mean、std、min 、1th、5th、10th、25th、50th、75th、90th、95th、max、ske、kur

. Interclass correlation coefficient (ICC) test was used to evaluate the consistency of measurement results by two radiologists. Independent sample

test or Mann-Whitney

test was used to compare the differences between the two groups. The receiver operating characteristic (ROC) curves were drawn

whichwere followed by the diagnostic per

formance analysis. The area under curves (AUCs) were compared between histogram parameters of vROI derived from two different

values by using DeLong test.

Results:

The results between two radiologists were consistent (ICC＞0.75). The ADC

800-min、5th、10th、25th

and ADC

1 500-mean、min、5th、10th、25th、50th

of PCa group were lower than those of BPH group (

＜0.05). The AUC value of ADC

1 500-mena、min、5th、10th

was higher than that of ADC

1 500-mena、min、5th、10th

(

＜0.05).

Conclusion:

vROI histogram based on DWI with high

value can differentiate PCa from in CG

and its diagnostic efficiency was higher than standard

value.

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The volumetric ROI histogram based on DWI with high b value in differentiating prostatic carcinoma from benign prostatic hyperplasia in central gland

DOI：10.19732/j.cnki.2096-6210.2022.05.011

摘要

Abstract

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