Application value of 2 mm tissue elasticity parameter around breast lesion to BI-RADS 4 masses

XING Xiaoxiao; QIAN Feng; ZHANG Qi; LIU Shuiqing; XIE Xiao; ZHAO Cheng

doi:10.19732/j.cnki.2096-6210.2022.05.013

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Application value of 2 mm tissue elasticity parameter around breast lesion to BI-RADS 4 masses

更新时间：2025-12-15

- Application value of 2 mm tissue elasticity parameter around breast lesion to BI-RADS 4 masses
- Vol. 31, Issue 5, Pages: 536-542(2022)
- 作者机构：
  
  1. 青岛大学附属医院超声科,山东,青岛,266500
  2. 苏州大学附属第三医院超声科,江苏,常州,213000
- 作者简介：
- 基金信息：
- DOI：10.19732/j.cnki.2096-6210.2022.05.013
  CLC：
- Published Online：28 October 2022，
  
  Published：28 October 2022
- 稿件说明：
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邢肖肖,钱丰,张琪,等. 乳腺病灶周围2 mm组织弹性参数对BI-RADS4类肿块的鉴别诊断价值[J]. 肿瘤影像学, 2022, 31(5): 536-542 https://doi.

org/10.19732/j.cnki.2096-6210.2022.05.013
邢肖肖,钱丰,张琪,等. 乳腺病灶周围2 mm组织弹性参数对BI-RADS4类肿块的鉴别诊断价值[J]. 肿瘤影像学, 2022, 31(5): 536-542 https://doi. DOI： 10.19732/j.cnki.2096-6210.2022.05.013.

org/10.19732/j.cnki.2096-6210.2022.05.013 DOI：

摘要

目的：

通过回顾性研究乳腺影像报告和数据系统（Breast Imaging Reporting and Data System，BI-RADS）4类肿块，探讨声触诊弹性成像（sound touch elastography，STE）中肿块的杨氏模量硬度值（Youngs modulus of mass，

）及其周围2 mm壳的杨氏模量硬度值（Youngs modulus of 2 mm shell，

）对乳腺BI-RADS 4类肿块的鉴别诊断价值。

方法：

选取2018年1月2020年12月于苏州大学附属第三医院就诊的210个BI-RADS 4类乳腺肿块作为训练组，68个BI-RADS 4类肿块作为验证组，定量评估病变区（

max

，

mean

，

min

，

）及病变周围宽度为2 mm的腺体组织（

max

，

mean

，

min

，

）的硬度值。以病理学检查结果为金标准，选取训练组对BI-RADS 4类肿块STE中诊断性能最高的弹性参数，取其截断值对68个BI-RADS4类肿块作为验证组进行性能评估，再分别对本研究组中BI-RADS 4A、4B、4C的肿块进行性能评估。

结果：

STE中肿块周围2 mm的壳（

max

）模量值诊断效能最高。应用

max

的最佳截断值（91.73 kPa）对68例BI-RADS 4类肿块进行性能评估，曲线下面积（area under curve，AUC）为0.774，BI-RADS 4A组AUC为0.822，约登指数0.64；BI-RADS 4B组AUC为0.703，约登指数0.41；BI-RADS 4C组AUC 0.501，约登指数0.002。

结论：

STE中

max

是鉴别诊断乳腺良恶性病变的重要辅助参数，对鉴别BI-RADS 4A类乳腺肿块更有价值，可减少BI-RADS 4A类肿块的不必要活检。

Abstract

Objective:

To investigate the application value of Youngs modulus of mass (

) and surrounding Youngs modulus of 2 mm shell (

) in sound touch elastography (STE) for breast BI-RADS 4 masses by retrospective study.

Methods:

A total of 210 Breast Imaging Reporting and Data System (BI-RADS) 4 breast masses treated in The Third Affiliated Hospital of Soochow University from January 2018 to December 2020 were selected as the training group and 68 BI-RADS 4 masses as the verification group. The hardness of the lesion area (

max

mean

min

) and the glandular tissue around the lesion (

max

mean

min

) were quantitatively evaluated. Taking the pathological results as the gold standard

the elastic parameters with the highest diagnostic performance in STE of BI-RADS 4 masses in the training group were selected

and their cutoff values were used to evaluate the performance of 68 BI-RADS 4 masses as the verification group

and then the performance of BI-RADS 4A

4B and 4C masses in this study group were evaluated respectively.

Results:

The diagnostic efficiency of the

max

modulus of 2 mm around the mass was the highest in STE imaging. The best cut-off value of

max

(91.73 kPa) was used to evaluate the performance of 68 cases of BI-RADS 4 masses. The area under curve (AUC) was 0.774

AUC 0.822 and Youden index 0.64 in BI-RADS 4A group; AUC 0.703 and Youden index 0.41 in BI-RADS 4B group

AUC 0.50 and Youden index 0.002 in BI-RADS 4C group

respectively.

Conclusion:

The value of

max

modulus in STE is an important auxiliary parameter in the differential diagnosis of benign and malignant breast lesions

and it is more valuable in distinguishing BI-RADS 4A breast masses

which can

reduce the unnecessary biopsy of BI-RADS 4A masses.

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